Nebivolol for lowering RHR

[malfeasance]

Hmmm . . .

I have been using metoprolol

Maybe not the best choice

Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans - PMC

We identified a deleterious effect of chronic administration of metoprolol on microvascular function during handgrip in hypertensive patients, which was not observed with nebivolol. The impaired muscle capillary recruitment during exercise may ...

pmc.ncbi.nlm.nih.gov

 

[malfeasance]

And another comparison with a beneficial outcome for nebivolol

https://www.ahajournals.org/doi/10.1161/JAHA.117.007437

 

[Sampei]

And another comparison with a beneficial outcome for nebivolol

https://www.ahajournals.org/doi/10.1161/JAHA.117.007437

Nebivolol Is the best at the Moment, I'm.not joking. If it doesn't work for someone yeah you need to try something else but if one can get away with nebivolol it's the best choice ever.

Every studies I have read it had better outcome and less side effect of every other meds

 

[malfeasance]

Nebivolol Is the best at the Moment, I'm.not joking. If it doesn't work for someone yeah you need to try something else but if one can get away with nebivolol it's the best choice ever.

Every studies I have read it had better outcome and less side effect of every other meds

Thanks, Sampei. I am going to read more about it and maybe order it from overseas or talk to my Dr about swapping my prescription if the studies are valid and show results like this in comparison to what I am using.

Is there already a thread here somewhere discussing this sort of comparison that might save me time? I'll add to it, if it exists.

 

[Sampei]

Thanks, Sampei. I am going to read more about it and maybe order it from overseas or talk to my Dr about swapping my prescription if the studies are valid and show results like this in comparison to what I am using.

Is there already a thread here somewhere discussing this sort of comparison that might save me time? I'll add to it, if it exists.

There isn't really a specific thread, me and ghoul have talked about it extensively in another thread but I don't remember which one.

You should just tell your doctor you having bad side effect with the one you are using and suggest trying nebivolol. If he push back just go the telehealth route. Cost pennies.

Read on few studies about nebivolol, it's just amazing, super selective, don't fuck with your brain or your dick, gives LVH protection. Side effect non existent for the majority of ppl.

 

[malfeasance]

Better for cardiovascular events than metoprolol

Nebivolol versus Carvedilol or Metoprolol in Patients Presenting with Acute Myocardial Infarction Complicated by Left Ventricular Dysfunction - PMC

The aim of this study was to evaluate the efficacy of nebivolol, carvedilol or metoprolol succinate on the outcome of patients presenting with acute myocardial infarction (AMI) complicated by left ventricular dysfunction. Patients (n = 172, aged ...

pmc.ncbi.nlm.nih.gov

 

[malfeasance]

Better on aortic pressure and ventricular wall thickness

https://www.ahajournals.org/doi/10.1161/hypertensionaha.110.155507

 

[malfeasance]

Results: Baseline demographic and clinical characteristics were similar in the three groups. The composite end point during follow-up was lower in the patients treated with nebivolol than those treated with metoprolol (14.5 vs. 31.5%; p = 0.03). However, event rates were similar between the patients treated with carvedilol and those treated with the metoprolol (20.3 vs. 31.5%, p > 0.05) and between the patients treated with nebivolol and carvedilol (14.5 vs. 20.3%, p > 0.05). Conclusion: The patients treated with nebivolol experienced 12-month cardiovascular events at a lower rate than those treated with metoprolol succinate. However, event rates were similar between the carvedilol and the metoprolol succinate groups and between the nebivolol and the carvedilol groups.

https://karger.com/mpp/article/25/4/316/204138/Nebivolol-versus-Carvedilol-or-Metoprolol-in

 

[malfeasance]

Less fatigue

Nebivolol Versus Metoprolol: Comparative Effects on Fatigue and Quality of Life

Beta-blockers are prescribed to millions of people for treatment of hypertension. Fatigue is a recognized and common side effect of beta-blockers that can have significant effects on quality of life. Worse, many people taking a beta-blocker for years are not even aware of the reduction of energy...

ctv.veeva.com

 

[malfeasance]

Hmmmm . . . . Ibid.
"Studies indicate that nebivolol, unlike most beta-blockers, does not cause constriction of peripheral blood vessels. Studies indicate that nebivolol, unlike most beta-blockers, does not cause constriction of peripheral blood vessels"

 

[Eddie.]

Do you take any ARBs or ACE inhibitors along Nebivolol?

Else: How many days have you been taking Nebivolol? Maybe try to take half the dose or a quarter, the active metabolites have a pretty long half life of about a day.
Have you monitored your RR/RHR more often? I mean it can happen to be "that low" sometimes.

You probably didn't understood my point. The issue ain't the RHR being low (which is actually high) but the blood pressure and especially the diastolic being too low.

First 3 days i took 2,5mg and it didn't do anything to my RHR. Then i changed to 5mg and i'm in that dose for about 8-9 days.

I don't take any other BP medication and i'm currently in a gram total of Test/Eq/Npp and 75mg anadrol.

 

[xrayphoton13]

Guys, do you notice a reduction in blood pressure as well besides RHR? I think I'm gonna stop taking it, it might have a lowering effect on my diastolic which was already below normal.

If blood pressure drops too much then heart rate has to come up to compensate for the lack of pressure. If that's the case then I'm fakked because it skews for the worse both parameters i care for.

Here's an example, I'm taking 5mg and for the first days my morning RHR was around 67-70. Now my BP dropped even further and RHR got high again.

Yeah definitely back off the dose. Nebivolol has been good to me and slowly lowers my BP. But telmisartan drops my diastolic fast like this. Even 10mg will get me in the 50s

 

[y777]

The other thing about Nabivolol I recall is that it’s the only beta blocker that works on e2 receptors in blood vessels , in addition to the adrenal receptors. That’s also beneficial for our sport.

Quick update started yesterday, RHR 85. today I’m at 73 for RHR. 5mg.

Hoping it continues to improve Over next few days /weeks.

 

[espresso123]

You probably didn't understood my point. The issue ain't the RHR being low (which is actually high) but the blood pressure and especially the diastolic being too low.

First 3 days i took 2,5mg and it didn't do anything to my RHR. Then i changed to 5mg and i'm in that dose for about 8-9 days.

I don't take any other BP medication and i'm currently in a gram total of Test/Eq/Npp and 75mg anadrol.

Yea I just didnt clarify my point well enaugh. I thought that perhaps an ARB or something reducing your RR so much so your body compensates for it increasing the RHR accordingly.

As this does not seem to be the case, you are reacting pretty sensitive to that substance and Id suggest taking half the dose or a quarter to find your sweetspot.

 

[Eddie.]

Yeah definitely back off the dose. Nebivolol has been good to me and slowly lowers my BP. But telmisartan drops my diastolic fast like this. Even 10mg will get me in the 50s

Yea I just didnt clarify my point well enaugh. I thought that perhaps an ARB or something reducing your RR so much so your body compensates for it increasing the RHR accordingly.

As this does not seem to be the case, you are reacting pretty sensitive to that substance and Id suggest taking half the dose or a quarter to find your sweetspot.

I'm gonna stop it completely, i see no point of taking 2,5mg if it doesn't reduce my RHR at all. Thing is nebivolol has a greater impact on the RHR and less on BP, in my case it goes backwards.

 

[NotHuman]

Guys, do you notice a reduction in blood pressure as well besides RHR? I think I'm gonna stop taking it, it might have a lowering effect on my diastolic which was already below normal.

If blood pressure drops too much then heart rate has to come up to compensate for the lack of pressure. If that's the case then I'm fakked because it skews for the worse both parameters i care for.

Here's an example, I'm taking 5mg and for the first days my morning RHR was around 67-70. Now my BP dropped even further and RHR got high again.

Very interesting. 43 is definitely not desirable. 70-80 is really the sweet spot when it comes to diastolic, but you could get by in the 60-70 range if it’s the only way to get systolic low enough. I would not want it to be lower.

 

[NotHuman]

I'm gonna stop it completely, i see no point of taking 2,5mg if it doesn't reduce my RHR at all. Thing is nebivolol has a greater impact on the RHR and less on BP, in my case it goes backwards.

I know for me, 2.5mg won’t really lower my RHR

 

[MyNameIsJeff]

Shout out to @My.Name.Is.Jeff for bringing Nebivolol to the bodybuilding community in 2017.

For me, 5mg lowers my RHR a bit, while 10mg has a stronger effect. I’m cautious about going too high with this because it can be too potent at lowering my blood pressure if I’m not careful.

Hey, you tagged my retarded doppelganger

Thanks for the compliment, we did some great work over the years on the PM forums. You, I, gotgame, Matt Porter, and many others helped to popularize the use of Telmisartan and Nebivolol as ancillaries. Crazy to see how widespread the use of these drugs is nowadays in bodybuilding circles. Maintaining heart health while on AAS

 

[Eddie.]

Very interesting. 43 is definitely not desirable. 70-80 is really the sweet spot when it comes to diastolic, but you could get by in the 60-70 range if it’s the only way to get systolic low enough. I would not want it to be lower.

Hey man, appreciate the response. I'm not trying to get it that low, it's just genetic. My "usual" bp without the nebivolol is like 105/55 to 112/58.

My RHR before i raise the calories for my off season and before adding the HGH was 67-72 but recently went up to 75-80 and i thought nebivolol would be good for reducing my heart rate. Unfortunately it seems it has an impact on lowering my blood pressure too and that leads to even further increase in RHR despite the nebivolol.

The only way i can bring my diastolic to 60-70 is by adding a ton of sodium but that leads to an unwanted increase in systolic too. The rarely times i saw my diastolic at 60-70 range i had a systolic of 130s.

 

[NotHuman]

Hey, you tagged my retarded doppelganger

Thanks for the compliment, we did some great work over the years on the PM forums. You, I, gotgame, Matt Porter, and many others helped to popularize the use of Telmisartan and Nebivolol as ancillaries. Crazy to see how widespread the use of these drugs is nowadays in bodybuilding circles. Maintaining heart health while on AAS

Oops! I just gave the credit to some random schmoe (apologies to said schmoe if you’re reading this).

I remember the thread you started about keeping the heart safe on AAS and posted tons of info on Nebivolol, which was essentially an unknown drug for most of us at the time. I needed something to help lower my heart rate so I instantly got excited about it and jumped on it. Been using it ever since.

GotGame was great. Too bad he isn’t around anymore after people kind of ran him off (tends to happen unfortunately). He gave me a lot of echocardiogram insight.