Nebivolol for lowering RHR

[DugPrime]

Might try nebivolol for rhr.
Tried literally everything to fix rhr (except cardio, cardio is the devil)

Cardio naturally brings my heart rate down from 90+ to 60-70 within 6 months; you should definitely do it. The real evils here are trestolone and clenbuterol, which makes my resting heart rate back to 100.

 

[bigboy420]

you should definitely do it.

I know... it was a joke.

But since my bloodpressure 120/80/80, low dose nebivolol sounds perfect

 

[Ghoul]

Yeah but many many years ago. It's on my list seeing a cardiologist and make all the necessary scans and checks, so far around my place with a little search i've done i haven't found anyone relatively young to speak freely about my gear use.

Don't assume a young doctor is any more accepting of gear use. Old ones have heard everything before. Or find one that's jacked.

 

[DugPrime]

I know... it was a joke.

But since my bloodpressure 120/80/80, low dose nebivolol sounds perfect

Oh yeah, with those levels, 2.5mg would puts you in the golden zone.

 

[Eddie.]

Don't assume a young doctor is any more accepting of gear use. Old ones have heard everything before. Or find one that's jacked.

I year ya.. I just have bad experience from an old cardiologist from my mother's situation while he can't regulate her BP, her morning measure is like 170/100 and afternoon 90/60..he was all over the place with her meds, i suggested some things and he wasn't even hearing.

Anyway, i'm in a situation where i'm moving to another town so i'll have to search again from the start. A schoolmate of mine is now one the best heart surgeons in the country, but he's solely into surgery field. Maybe he will be able to suggest a colleague that i can go to.

 

[Ghoul]

I year ya.. I just have bad experience from an old cardiologist from my mother's situation while he can't regulate her BP, her morning measure is like 170/100 and afternoon 90/60..he was all over the place with her meds, i suggested some things and he wasn't even hearing.

Anyway, i'm in a situation where i'm moving to another town so i'll have to search again from the start. A schoolmate of mine is now one the best heart surgeons in the country, but he's solely into surgery field. Maybe he will be able to suggest a colleague that i can go to.

If possible, set your healthcare up at a university affiliated hospital/health system. In general, they tend to be closer to the leading edge of medical science, vs the smaller places and independents who often seem to have stopped learning shortly after getting their qualifications.

 

[xrayphoton13]

If possible, set your healthcare up at a university affiliated hospital/health system. In general, they tend to be closer to the leading edge of medical science, vs the smaller places and independents who often seem to have stopped learning shortly after getting their qualifications.

I always wondered about this. I work at a level 1 trauma center/teaching hospital that's connected to a major med school. I'll listen to the attendings telling their residents and fellows about the latest research and studies going on. I always wondered how well doctors stay up to date on these things if they work private practice in a clinic somewhere. I'm sure they have continuing education requirements but I have no clue how thorough or demanding it is

 

[y777]

Hi guys.

Just wanted to give some data points. Got Nebivolol last Saturday and have been taking it 5mg daily on top of 80 Telmisartan

Starting stats:
RHR 85
+1 day = 76
+2d = 70
+3d = 71

BP
138/70 starting
+1d = 136/71
+2d = 126/72
+3d = 121 /64


Cardio wise I’m just doing 30-60min fasted z2 cardio in the mornings to help w the cut.

Question for folks who’ve been faking Nabivolol for longer time:

should I expect further RHR reduction just from the drug itself or it’s pretty much tapped out here ?

Suppose the other ways are
1. Bump dose to 10mg but at that level it’s not cardio selective as 5mg. Would rather not cuz 5 is my rx dose

2. Change the gear stack. I’m coming off tren hex in about a month so I’ll see some improvement just from that.

3. More cardio at higher intensity? Doing z2 to help w a cut right now.

4. Running cardarine now for a couple of weeks already. Not sure if it helps w RHR. primarily running it to help w HDL (form DHT compouns use) and maintain endurance while using tren.
Not sure if cardarine helps w RHR metrics.

 

[Sampei]

Hi guys.

Just wanted to give some data points. Got Nebivolol last Saturday and have been taking it 5mg daily on top of 80 Telmisartan

Starting stats:
RHR 85
+1 day = 76
+2d = 70
+3d = 71

BP
138/70 starting
+1d = 136/71
+2d = 126/72
+3d = 121 /64


Cardio wise I’m just doing 30-60min fasted z2 cardio in the mornings to help w the cut.

Question for folks who’ve been faking Nabivolol for longer time:

should I expect further RHR reduction just from the drug itself or it’s pretty much tapped out here ?

Suppose the other ways are
1. Bump dose to 10mg but at that level it’s not cardio selective as 5mg. Would rather not cuz 5 is my rx dose

2. Change the gear stack. I’m coming off tren hex in about a month so I’ll see some improvement just from that.

3. More cardio at higher intensity? Doing z2 to help w a cut right now.

4. Running cardarine now for a couple of weeks already. Not sure if it helps w RHR. primarily running it to help w HDL (form DHT compouns use) and maintain endurance while using tren.
Not sure if cardarine helps w RHR metrics.

At 10mg is considered still very cardio selective, it stop being cardio selective above 10mg

 

[BP_6]

At 10mg is considered still very cardio selective, it stop being cardio selective above 10mg

Correct. The general prescribed dosages on average are you start with 5mg, and go up from there. I can't even say I have ever seen anyone using more than 10mg. However the max effective dosage is actually 40mg, so 10mg is still considered a low dose.

On an anecdotal note, I never notice any difference besides a bit better BP control on 10 vs 5. Felt the exact same on both dosages. My doc even told me he never prescribes more than 10mg and would rather add another BP medicine if more is needed.

 

[Sampei]

Correct. The general prescribed dosages on average are you start with 5mg, and go up from there. I can't even say I have ever seen anyone using more than 10mg. However the max effective dosage is actually 40mg, so 10mg is still considered a low dose.

On an anecdotal note, I never notice any difference besides a bit better BP control on 10 vs 5. Felt the exact same on both dosages. My doc even told me he never prescribes more than 10mg and would rather add another BP medicine if more is needed.

Yeah usually one first get to the higher dosage of the arbs or ace or whatever like telmisartan so you go 80mg there and stay at 5mg nebivolol. Than you go 10mg nebi if it's not enough and if you still need more you add a diuretic like indapamide or similar.

 

[Ghoul]

I always wondered about this. I work at a level 1 trauma center/teaching hospital that's connected to a major med school. I'll listen to the attendings telling their residents and fellows about the latest research and studies going on. I always wondered how well doctors stay up to date on these things if they work private practice in a clinic somewhere. I'm sure they have continuing education requirements but I have no clue how thorough or demanding it is

It's like anything else, for most, medicine is a job, and the bare minimum training will be adhered to. For a small minority, it's a passion, and they'll stay on top of developments. read journals, studies, attend conferences.

In a university environment they'll be exposed to new information by lectures, have opportunities to participate in research, and often have educational duties requiring them to stay current.

I have a skin condition that appeared
out of nowhere, seemingly an allergic reaction to medication, leaving hundreds of what appeared to be tiny scars over my arms and ankles. Over a decade I've seen 5 dermatologists.. Each time there's been no firm diagnosis, and none of the prescribed treatments has been effective. I had essentially given up.

If you've seen my other posts, you'll know I'm tenacious when it comes to researching the best treatments, and will find the best specialists in the world in pursuit of cures. Yet I still hit a brick wall.

While seeing a dermatologist for something else at an ivy league connected hospital, I showed the resident what was going on. He took a look, repeated an incurable diagnosis I heard before, and suggested I keep the area moisturized to minimize their appearance. He asked me to wait a moment, and came back with a professor.

The professor pulled out a magnifying glass, looked at it, handed it to the resident and started asking him questions about what he saw.

In seconds, he accurately diagnosed it as a rare genetic condition I had never heard of. Told me a cure had recently been discovered, and showed the resident how to order a $50 cream to be compounded by a speciality pharmacy, bizarrely made of an oral statin and cholesterol in a penetrating base.

Within a month, the scars disappeared, and my skin was completely cleared.

Had I not been there, I suspect I'd have been stuck looking like I spent a lot of time getting scratched up by thorn bushes for the rest of my life.

 

[rexy]

I also don't notice a difference in any sort of sides going from 5mg to 10mg. I run 5mg as a basal dose anytime i'm on gear as it keeps my blood pressure just under threshold, and RHR 60-65. However, like clockwork, if I use Tren or Anavar/Winstrol/Anadrol, that dose has to go to 10mg to stay at the same RHR and BP.

I've just added HGH in for the first time whilst on Tren and Anavar, and had to take an extra 2.5mg as it seems like 10mg isn't going to be enough to control the onslaught with HGH on top, which is known to raise RHR by itself anyway. I'll see how it goes as it may settle. I don't like to go above 10mg, but not because I'm concerned about selectiveness; I just see it as a sign to lower the androgen load because the need for more beta blocking is a proxy for pushing too much in terms of those particular CNS stimulating compounds.

That said, it's not like it becoming less selective >10mg will be a bad thing in my situation. I find less-selective beta blockers lower my HR better. The issue is usually memory problems (on propranolol for instance). It's still not going to be a blunt hammer >10mg in the way those earlier generation ones are though. Here are my notes on Nebivolol:

• at doses ≤10 mg nebivolol preferentially blocks beta1-receptors.
  
  
• Blocks both β1- and β2-adrenergic receptors in poor CYP2D6 metabolizers and at doses >10 mg.
  
  
• Nebivolol, unlike other beta-blockers, also produces an endothelium-derived nitric oxide-dependent vasodilation resulting in a reduction of systemic vascular resistance.
  
  
• Frequent administration (i.e., daily divided doses) unlikely to be more beneficial than once-daily administration.

 

[Sampei]

Yeah HGH it's a little fucker for RHR

Add GLP1 and some AAS and you got a combo killer for RHR

I also don't notice a difference in any sort of sides going from 5mg to 10mg. I run 5mg as a basal dose anytime i'm on gear as it keeps my blood pressure just under threshold, and RHR 60-65. However, like clockwork, if I use Tren or Anavar/Winstrol/Anadrol, that dose has to go to 10mg to stay at the same RHR and BP.

I've just added HGH in for the first time whilst on Tren and Anavar, and had to take an extra 2.5mg as it seems like 10mg isn't going to be enough to control the onslaught with HGH on top, which is known to raise RHR by itself anyway. I'll see how it goes as it may settle. I don't like to go above 10mg, but not because I'm concerned about selectiveness; I just see it as a sign to lower the androgen load because the need for more beta blocking is a proxy for perhaps pushing too much in terms of doses.

That said, it's not like it becoming less selective >10mg will be a bad thing in my situation. I find less-selective beta blockers lower my HR better. The issue is usually memory problems (on propranolol for instance). It's still not going to be a blunt hammer >10mg in the way those earlier generation ones are though. Here are my notes on Nebivolol:

• at doses ≤10 mg nebivolol preferentially blocks beta1-receptors.
  
  
• Blocks both β1- and β2-adrenergic receptors in poor CYP2D6 metabolizers and at doses >10 mg.
  
  
• Nebivolol, unlike other beta-blockers, also produces an endothelium-derived nitric oxide-dependent vasodilation resulting in a reduction of systemic vascular resistance.
  
  
• Frequent administration (i.e., daily divided doses) unlikely to be more beneficial than once-daily administration.

 

[y777]

Finally managed to get more than 4-5 hrs sleep (running hex now) and BP is 111/62

RHR still 73

Is there a level of BP wheee you’d start lowering the meds either Telmisartan or Nabivolol , taking 80 and 5, respectively

Thanks guys.

 

[Ghoul]

Finally managed to get more than 4-5 hrs sleep (running hex now) and BP is 111/62

RHR still 73

Is there a level of BP wheee you’d start lowering the meds either Telmisartan or Nabivolol , taking 80 and 5, respectively

Thanks guys.

The difference in effectiveness between 40mg and 80mg of Telm is minimal.

I would lower the dose to 40mg at this point. Keep in mind it takes 4 weeks to reach a stable BP with Telmisartan. Most of the effect is reached after 2 weeks.