Nebivolol for lowering RHR

[Ghoul]

The difference in 80mg over 40mg Telmisartan is greater PPAR/insulin sensitivity benefits. The BP reduction at the higher dose isn’t much more than 40mg.

Correct I could've been more specific, and was referring specifically to BP control.

He doesn't want BP to go lower than where he's at now.

 

[rexy]

I also don't notice a difference in any sort of sides going from 5mg to 10mg. I run 5mg as a basal dose anytime i'm on gear as it keeps my blood pressure just under threshold, and RHR 60-65. However, like clockwork, if I use Tren or Anavar/Winstrol/Anadrol, that dose has to go to 10mg to stay at the same RHR and BP.

I've just added HGH in for the first time whilst on Tren and Anavar, and had to take an extra 2.5mg as it seems like 10mg isn't going to be enough to control the onslaught with HGH on top, which is known to raise RHR by itself anyway. I'll see how it goes as it may settle. I don't like to go above 10mg, but not because I'm concerned about selectiveness; I just see it as a sign to lower the androgen load because the need for more beta blocking is a proxy for pushing too much in terms of those particular CNS stimulating compounds.

That said, it's not like it becoming less selective >10mg will be a bad thing in my situation. I find less-selective beta blockers lower my HR better. The issue is usually memory problems (on propranolol for instance). It's still not going to be a blunt hammer >10mg in the way those earlier generation ones are though. Here are my notes on Nebivolol:

• at doses ≤10 mg nebivolol preferentially blocks beta1-receptors.
  
  
• Blocks both β1- and β2-adrenergic receptors in poor CYP2D6 metabolizers and at doses >10 mg.
  
  
• Nebivolol, unlike other beta-blockers, also produces an endothelium-derived nitric oxide-dependent vasodilation resulting in a reduction of systemic vascular resistance.
  
  
• Frequent administration (i.e., daily divided doses) unlikely to be more beneficial than once-daily administration.

OK so I tried different timings with Nebivolol and Anavar and have found what works to get my HR back to where it should be on the same dose of Nebivolol as before introducing the Var and HGH.

For anyone who's interested, here's what I was doing previously:

- 20mg Anavar dosed in the AM after waking.

- GH pre-workout and 2.5 hours before I plan to do the cardio for fat loss. Usually this was at the same time as the Anavar or a few hours after if the workout time had to slip.

- Full 10mg Nebivolol dosed post-workout, around 3pm, so approx 6hours after the prior two were taken. The logic being to limit the effect of it on a workout by having it almost 20 hours before the next one.

Clearly the timing of anavar and HGH was not helping due to it hitting as Nebivolol was getting to its lowest levels. I would also be falling asleep from fatigue due to anavar in the early afternoon. This is not related to HGH because I don't experience fatigue from it, and it was happening anytime I used Anavar or Winstrol AM like clockwork.

Here's what I do now:
- Anavar + Winstrol (so basically any orals) and HALF of my Nebivolol dosed just before bed (20mg Anavar, 25mg Winstrol, 5mg Nebivolol). The initial night combining these was to really try push things cardiac-wise, as both orals stimulate my HR. I also wanted to see if I could offset the fatigue they bring by just taking them at night.

- GH still the same, always AM with a few hours difference depending upon workout timing which doesn't vary too much. Same 5IU dose.

- Last 5mg of Nebivolol taken at usual time post-workout and around 3pm, for a total of 10mg Nebivolol.

Although the medical guidance suggests no benefit to splitting Nebivolol dose, there definitely is for PED purposes.

On the first day trying the orals and nebivolol at night, I had also dosed 100mg Tren E around 6pm, so that too was peaking overnight, as the Anavar and Winstrol was hitting. I expected a disaster. However, I slept like a baby, and the morning after, I woke and waited 10 mins to measure BP. It was 122/67 with a RHR of 71, when previously I had been reading 135/81+ consistently and HR up to 85.

Then, I did a 5IU HGH injection and went to the gym. Did not feel any negative effect of the previous night's nebivolol on the workout, and no HR increase from the HGH interferring which it has done previously. I also had what felt like a 'stronger' heart beat previously, which has gone. Especially during workouts which was getting annoying. So I'm pleased about that.

I'd also note - feeling no fatigue from the orals or sleepiness in the afternoon either. Looks like I've found what nails it for me, and splitting nebivolol and taking any problematic orals at night can indeed work wonders if it suits your body.

Hope this helps someone. @malfeasance