Oral tirzepatide and semaglutide

[Hardtimes]

I see the oral version of tirz and sema on a few suppliers lists and was wondering if they are effective or have good bioavailability? Can’t seem to find anything online about whether they work or how often to does. It’s strange both tabs are 500mcg when the injection doses for the two are quite different.

 

[BP_6]

From what I have been told, they do work but the amount you have to take to get a similar effect makes the injectable version a much, much better value. I can only see a purpose if you had a lot of extra $ to spend combined with some major phobia of needles.

 

[Hardtimes]

Thanks I’m not a huge fan of needles but have just learned to suck it up. Just thought if the oral version worked in a similar way it could be handy when I travel for longer periods but I’ll leave it.

 

[IronMetal_2]

Doesn't work unfortunately, or you will need extraordinary doses.

Pharmaceutical oral semaglutide (rybelsus) is specifically formulated using SNAC to increase bioavailability and still only reaches 1-2% bioavailability. You need 14 mg Rybelsus every day to equal like 1 mg of subq semaglutide / week.
That is using the special formulation. Without SNAC, it almost has no oral bioavailability, so pretty much useless unless you maybe take 100mg per day?

 

[Rkl]

Oral tirz is a scam.

 

[clearheaded]

it works, compounders are making sublingual tablets. buy raws not vials..

there is some papers about this and just read about a dr that rx compounded tablets..

no you dont need snac. yes doses are higher, like every other drug.

 

[IronMetal_2]

it works, compounders are making sublingual tablets. buy raws not vials..

there is some papers about this and just read about a dr that rx compounded tablets..

no you dont need snac. yes doses are higher, like every other drug.

can you cite the papers please? thanks mate

 

[mochul]

It works but dosage that is required is way more and should be taken daily and it’s not still effective as injectable. There are certain formulation to make the drug more resistant to gi tract but it’s not enough. Normal ozempic injection dosage is 0.25 mcg while oral is 14mg daily!!!

 

[MrCloud]

if it worked why wouldnt any pharma company come out with an oral one ? they spend billions per year in r&d and the best they could do is injectables

 

[Ghoul]

if it worked why wouldnt any pharma company come out with an oral one ? they spend billions per year in r&d and the best they could do is injectables

Because they wouldn't want to make hundreds of billions by eliminating the biggest obstacle for most potential buyers....a needle.

 

[thejumpingsheep]

Anecdotal accounts from folks who claimed to try it on Reddit seem to all state that it doesn't work. They all seemed to post for the purpose of asking whether or not its a scam. I havent read an accounting from anyone who said it did work for them. That said, there arent a lot of posts on the oral version and I dont remember the dosages people were taking. So a lot of variables... involved. I dont think anyone even knows what dosage you need for oral tirz.

From what I have learned in my short time here is that you should inject when you have the option. Orals seems to have more serious side effects.

 

[Ghoul]

Anecdotal accounts from folks who claimed to try it on Reddit seem to all state that it doesn't work. They all seemed to post for the purpose of asking whether or not its a scam. I havent read an accounting from anyone who said it did work for them. That said, there arent a lot of posts on the oral version and I dont remember the dosages people were taking. So a lot of variables... involved. I dont think anyone even knows what dosage you need for oral tirz.

From what I have learned in my short time here is that you should inject when you have the option. Orals seems to have more serious side effects.

There are billions to be made with a practical oral GLP, All efforts thus far have failed. And yes, Rybelsus, daily 14mg, or 100mg a week for results not as good as 2.4mg once a week Ozempic, is a failure.

 

[Tawny]

I see the oral version of tirz and sema on a few suppliers lists and was wondering if they are effective or have good bioavailability? Can’t seem to find anything online about whether they work or how often to does. It’s strange both tabs are 500mcg when the injection doses for the two are quite different.

I know that the sema oral works great. As in having to split the dose it worked so good. Just food for thought.

 

[thejumpingsheep]

I know that the sema oral works great. As in having to split the dose it worked so good. Just food for thought.

Dosage? Im curious because yours is the 1st account i have read that said it worked.

 

[Ghoul]

Dosage? Im curious because yours is the 1st account i have read that said it worked.

The pharma oral is 14mg/day, for the equivalent effect of 1mg/week subq.

 

[Tawny]

Dosage? Im curious because yours is the 1st account i have read that said it worked.

Honestly not sure. I personally use Tirz. I know someone taking oral sema and the appetite suppression and side effects were too much so they halved the pill. Same side effects as using subq.