Oral tirzepatide and semaglutide

[Hardtimes]

I see the oral version of tirz and sema on a few suppliers lists and was wondering if they are effective or have good bioavailability? Can’t seem to find anything online about whether they work or how often to does. It’s strange both tabs are 500mcg when the injection doses for the two are quite different.

 

[BP_6]

From what I have been told, they do work but the amount you have to take to get a similar effect makes the injectable version a much, much better value. I can only see a purpose if you had a lot of extra $ to spend combined with some major phobia of needles.

 

[Hardtimes]

Thanks I’m not a huge fan of needles but have just learned to suck it up. Just thought if the oral version worked in a similar way it could be handy when I travel for longer periods but I’ll leave it.

 

[IronMetal_2]

Doesn't work unfortunately, or you will need extraordinary doses.

Pharmaceutical oral semaglutide (rybelsus) is specifically formulated using SNAC to increase bioavailability and still only reaches 1-2% bioavailability. You need 14 mg Rybelsus every day to equal like 1 mg of subq semaglutide / week.
That is using the special formulation. Without SNAC, it almost has no oral bioavailability, so pretty much useless unless you maybe take 100mg per day?