Osteoblast-boosting stack

[Wombr]

After cracking a metacarpal during kick-boxing, I’m on a mission to build stronger, denser bones. I’ve combed through this osteoporosis mega-thread (Osteoporosis) and plenty of papers and ended up with the stack below:

Layer	Compound	Cliff-note rationale
Base androgen	Test E 300 mg/wk	AR drive plus the estradiol you need for mineralisation
IGF axis	HGH 5–12 IU/d	IGF-1 surge ➜ formation, mineralisation, remodelling
Oral helper	Anavar 10–20 mg/d	Shown to raise BMD / height velocity in clinical use
Epigenetic boost	Vorinostat 10–20 mg QD, 2 w on / 2 w off	HDAC-i keeps RUNX2, AR genes switched on
PTH analog	Abaloparatide 80 mcg QD or Teriparatide 20 mcg QD	Big jump in osteoblast number & activity
Anti-resorptive	Denosumab 60 mg q6 mo	Knocks osteoclasts down so gains stick

(Vit D, K2, calcium, magnesium, boron, etc. already dialled in.)
Sourcing headache:
Test, GH and Anavar are easy. The rest… not so much. Most leads (Made-in-China, IndiaMart) are quoting 500-vial / 1 kg minimum orders.

Any reliable pharmacies, clinics or other vendors you’ve used/ recommend? Also open to thoughts on the compound selection—anything obvious missing?
Appreciate the help!

 

[Benf15harp]

Chocolate milk is widely available.

 

[Spaceman Spiff]

After cracking a metacarpal during kick-boxing, I’m on a mission to build stronger, denser bones. I’ve combed through this osteoporosis mega-thread (Osteoporosis) and plenty of papers and ended up with the stack below:

Layer	Compound	Cliff-note rationale
Base androgen	Test E 300 mg/wk	AR drive plus the estradiol you need for mineralisation
IGF axis	HGH 5–12 IU/d	IGF-1 surge ➜ formation, mineralisation, remodelling
Oral helper	Anavar 10–20 mg/d	Shown to raise BMD / height velocity in clinical use
Epigenetic boost	Vorinostat 10–20 mg QD, 2 w on / 2 w off	HDAC-i keeps RUNX2, AR genes switched on
PTH analog	Abaloparatide 80 mcg QD or Teriparatide 20 mcg QD	Big jump in osteoblast number & activity
Anti-resorptive	Denosumab 60 mg q6 mo	Knocks osteoclasts down so gains stick

(Vit D, K2, calcium, magnesium, boron, etc. already dialled in.)
Sourcing headache:
Test, GH and Anavar are easy. The rest… not so much. Most leads (Made-in-China, IndiaMart) are quoting 500-vial / 1 kg minimum orders.

Any reliable pharmacies, clinics or other vendors you’ve used/ recommend? Also open to thoughts on the compound selection—anything obvious missing?
Appreciate the help!

dont you thinking this is all overkill? Especially with denosumab. Have you got a BMD scan to see if you have a bone problem?



In regards to sources, No one is going to spoon feed you

 

[Wombr]

dont you thinking this is all overkill? Especially with denosumab Have you got a BMD scan to see if you have a bone problem?



In regards to sources, No one is going to spoon feed you

I do, test and hgh does most of the heavy lifting, the other compounds are just nice add-ons.

 

[Scientific]

After cracking a metacarpal during kick-boxing, I’m on a mission to build stronger, denser bones. I’ve combed through this osteoporosis mega-thread (Osteoporosis) and plenty of papers and ended up with the stack below:

Layer	Compound	Cliff-note rationale
Base androgen	Test E 300 mg/wk	AR drive plus the estradiol you need for mineralisation
IGF axis	HGH 5–12 IU/d	IGF-1 surge ➜ formation, mineralisation, remodelling
Oral helper	Anavar 10–20 mg/d	Shown to raise BMD / height velocity in clinical use
Epigenetic boost	Vorinostat 10–20 mg QD, 2 w on / 2 w off	HDAC-i keeps RUNX2, AR genes switched on
PTH analog	Abaloparatide 80 mcg QD or Teriparatide 20 mcg QD	Big jump in osteoblast number & activity
Anti-resorptive	Denosumab 60 mg q6 mo	Knocks osteoclasts down so gains stick

(Vit D, K2, calcium, magnesium, boron, etc. already dialled in.)
Sourcing headache:
Test, GH and Anavar are easy. The rest… not so much. Most leads (Made-in-China, IndiaMart) are quoting 500-vial / 1 kg minimum orders.

Any reliable pharmacies, clinics or other vendors you’ve used/ recommend? Also open to thoughts on the compound selection—anything obvious missing?
Appreciate the help!

Update?

 

[Wombr]

Update?

Couldnt find a source I trust. Going to continue with primarily test and hgh.

 

[IndividualMan]

why post this protocol if you are not sure if you can even source the compounds?

thats like me saying I am going to run tren undecanoate Dienolone, 2mg Increlex Daily and Primo E at 1g/wk formy next cycle, even though I am 100% certain i cannot source/afford these compounds at the moment.

Its just daydreaming at this point

 

[Wombr]

why post this protocol if you are not sure if you can even source the compounds?

thats like me saying I am goig tu run tren undecanoate Dienolone, 2mg Increlex Daily and Primo E at 1g/wk formy next cycle, even though I am 100% certain i cannot source/afford these compounds at the moment.

Its just daydreaming at this point

Never said I was going to run it. I posted this to ask for opinions and advice

 

[IndividualMan]

what for tho? on paper this all looks good, but i do not think anyone here has ever run 2 or more of these at the same time due to them being so niche, so its all just opinions without experience.
Thanks for clarifying tho, plus shedding light on the high MOQs. that stuff is actually really helpful to know.

 

[Wombr]

what for tho? on paper this all looks good, but i do not think anyone here has ever run 2 or more of these at the same time due to them being so niche, so its all just opinions without experience.
Thanks for clarifying tho, plus shedding light on the high MOQs. that stuff is actually really helpful to know.

I guess just because. Its all experimental.
The stuff i was able to find on made in china was being sold by a paint manufacturer. Indiamart seems a bit better but still, unless you can get a prescription for it (you wont unless your grandma gets it for you) I wouldn’t mess with it.

 

[Jeffholio5]

Try adequan get an rx for your dog.

 

[Photon]

Try adequan get an rx for your dog.

Have not heard of this before.
Only approved in animals, no bio equivalent in humans.

Looks almost like an inject-able peptide consisting of aminos.

 

[Jeffholio5]

Have not heard of this before.
Only approved in animals, no bio equivalent in humans.

Looks almost like an inject-able peptide consisting of aminos.

A lot of what we inject was only approved for horses and cattle so id guess if it works for dogs and horses probably work on a weight adjusted basis in humans fairly well? But yeah I feel like with how well I’ve seen it help my dog I imagine it could help a lot of body builders with their messed up joints.

 

[Photon]

A lot of what we inject was only approved for horses and cattle so id guess if it works for dogs and horses probably work on a weight adjusted basis in humans fairly well? But yeah I feel like with how well I’ve seen it help my dog I imagine it could help a lot of body builders with their messed up joints.

It does look like inject-able glucosamine which is best pinned IA.
I see it's also done IM and SubQ but I believe oral bioavailability is really high so I'm not sure how it works

 

[BigDadd7]

why post this protocol if you are not sure if you can even source the compounds?

thats like me saying I am going to run tren undecanoate Dienolone, 2mg Increlex Daily and Primo E at 1g/wk formy next cycle, even though I am 100% certain i cannot source/afford these compounds at the moment.

Its just daydreaming at this point

I'm going to do 6 big titted blondes with fat asses today. Just dreaming, of course.

 

[Spaceman Spiff]

I'm going to do 6 big titted blondes with fat asses today. Just dreaming, of course.

Way to aim low

 

[BigDadd7]

Way to aim low

I didn't want to disappoint anyone.

 

[knucklesamich]

A lot of what we inject was only approved for horses and cattle so id guess if it works for dogs and horses probably work on a weight adjusted basis in humans fairly well? But yeah I feel like with how well I’ve seen it help my dog I imagine it could help a lot of body builders with their messed up joints.

Right? I have a cat that lost a bunch of weight because of an infection of some sort. The vets gave her a shot of antibiotics AND a substance that you rub into the skin of the top/inner part of the ear, it's an appetite stimulant--Mirtazapine. She says, "Make sure you use rubber gloves when you apply the ointment, or you'll be very hungry later." My mind is like, "REALLY?!"

An ointment that you apply through the skin that'll make you hungry?

 

[william_molecule]

After cracking a metacarpal during kick-boxing, I’m on a mission to build stronger, denser bones. I’ve combed through this osteoporosis mega-thread (Osteoporosis) and plenty of papers and ended up with the stack below:

Layer	Compound	Cliff-note rationale
Base androgen	Test E 300 mg/wk	AR drive plus the estradiol you need for mineralisation
IGF axis	HGH 5–12 IU/d	IGF-1 surge ➜ formation, mineralisation, remodelling
Oral helper	Anavar 10–20 mg/d	Shown to raise BMD / height velocity in clinical use
Epigenetic boost	Vorinostat 10–20 mg QD, 2 w on / 2 w off	HDAC-i keeps RUNX2, AR genes switched on
PTH analog	Abaloparatide 80 mcg QD or Teriparatide 20 mcg QD	Big jump in osteoblast number & activity
Anti-resorptive	Denosumab 60 mg q6 mo	Knocks osteoclasts down so gains stick

(Vit D, K2, calcium, magnesium, boron, etc. already dialled in.)
Sourcing headache:
Test, GH and Anavar are easy. The rest… not so much. Most leads (Made-in-China, IndiaMart) are quoting 500-vial / 1 kg minimum orders.

Any reliable pharmacies, clinics or other vendors you’ve used/ recommend? Also open to thoughts on the compound selection—anything obvious missing?
Appreciate the help!

where are you sourcing abaloparatide

 

[Wombr]

where are you sourcing abaloparatide

Molecule