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Penile Atrophy, Zero Libido, Ejaculatory Anhedonia, Bloodtests Back

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PainIsGrowth

New Member
Hello Forum,
Thank you very much for providing the right direction to look for finding what is going wrong in my body. I had the recommended blood tests done from this post, done at Quest.
https://thinksteroids.com/community/threads/134254957

Again, here are my main symptoms.
* Zero Libido/Sex Drive
* Bad Erectile Dysfunction even when using max doses of Cialis or Levitra
* Loss of Morning / Spontaneous / Nocturnal Erections
* Penile Tissue Changes (narrowing, shrinkage, curving, numbness, wrinkled)
* Penis Feels "disconnected" from head or body

****Complete loss of pleasure during Orgasm, this is new during last month. I know oxytocin is created by the pituitary, so I'm wondering is something is damaged there? I literally have no sensation during sex/masturbation, a slight sensation at approach of orgasm, and then nothing when there used to be a massive euphoric rush and tingly sensation thoughout my body. This is worrying me the most now.
Here are the results: In Range Out of Range Refererence Range
Estrogens, Fractionated, LC/MS/MS
Estrone, LC/MS/MS 23 pg/ml
Reference Range: < OR = 68

ESTRADIOL, ULTRASENSITIVE 48 H pg/mL
Reference Range: < OR = 29

Estriold, Serem <0.10 ng/mL
Reference Range:
Adults: 0.2 or LESS

Hepatic Function Panel
Only listing things out of range:
ALBUMIN 5.2 H Range : 3.6 - 5.1 g/dL
AST 88 H Range: 10-40 U/L
ALT 81 H Range: 9 -60 U/L

New Testosterone Results, FREE BIO TOTAL LC/MS/MS Range:

Testosterone Total 1081 250-1100 ng/dL
Testosterone Free 127.8 46.0 - 224.0 pg/mL
Testosterone BioAva 301.7 110.0-575.0 ng/dL
SHBG 44 7-49 nmol/L
Albumin Serum 5.2 H 3.6-5.1 g/dL


Estrogens, Total Serum 116 pg/mL Reference Range 130 or LESS

Progesterone, LC/MS/MS .3 ng/mL Reference Range .3 or LESS

PREGNENOLONE 39 ng/dL Reference Range 10-200

Dihydrotestosterone FREE Serum: PENDING, will know tomorrow
ESTRADIOL, FREE, LC/MS/MS PENDING, will know tomorrow

CBC = everything within range

ALDOSTERONE 13 ng/dL

CORTISOL, TOTAL 26.9 mcg/dL H
Reference Range for 8AM (7-9AM) 4.0 to 22.0
Reference Range for 4PM (3-5PM) 3.0-17.0
(I took this bloodtest at 11am, after a stressful situation trying to get the doctor to order these tests)
Range
DHEA Sulfate 302 110-510 mcg/dL
FSH 1.4 L 1.6-8.0 mIU/mL
LH 3.9 1.5-9.3 mIU/mL
Prolactin 8.7 2.0 - 18.0 ng/mL
T-4, Free 1.3 0.8 - 1.8 ng/dL
TSH, 3rd Gen 2.23 0.40 - 4.50 mIU/L
PSA, total 0.8 < or = 4.0 ng/mL

T3, FREE 297 230- 420 pg/dL
**********************************************************************************************
I know its a lot to look at, but I really appreciate anyone's help. I'll post the DHT and free estradiol tomorrow when I get it, but until then, please let me know what you think the most likely cause of these symptoms are. Urologists up to this point offer nothing but cialis, which barely works. Within the last month, the ejaculatory anhedonia is really scary! Is the low FSH with the high estradiol ultrasensitive enough to warrant an MRI for a brain tumor? How can I bring the Estradiol down naturally? Is my LH really "normal", and what causes FSH to be low? My old testosterone and thyroid results were done in June, so if you reference them, thats the date. Thanks again.
 
Hmmm...Free T3 is low...Should be at least 330 pg/dL. I am surprised your TSH is not higher than that though. You need to be under the care of a good Dr Bro...This is definitely not a case you can figure out on your own.
 
I had this same problem but your not on TRT anyway it is your high Estradiol levels. I had bad ED and could not reach an orgasm and if I did could not feel it. I got my Estradiol tested and it was dam high I needed to go on Arimidex .5mgs eveyday for 6 weeks to get it down. The labs you had done are a new one that just came out the range is <OR=29 at the time of my test my range was 13 to 54 pg/ml I was 90. Your at 48 so if 29 = 54 your 48 is just under 100 compared to my test.

With Estradiol this high it will mess with your Thyroid levels and your Cortisol your Aldosterone at 13 is dam low and getting your Estradiol levels down can change this. Your Free T will come back up and your SHBG should go down.

I would not worrry about your LH and FSH with a total T this high. You brain is just not asking for more.

This first thing that happened to me getting my Estradiol down was a big loss of water weight. Then come morning and night time wood. I was then able to have sex with my wife and reach an orgasm for the first time in 10 yrs.

Now you dam young to have this high Estradiol do you eat or drink a lot of SOY in your diet this will do this.

I would first get this down and then retest to see how things changed.

You still could have this problem I posted to you some days ago.
http://www.aafp.org/afp/990301ap/1190.html
http://www.pituitary.org/disorders/prolactinomas.aspx
 
have you lookied into the possibility of Diabetes ? alot of what you wrote is greek to me but, your header looks diabetic ??

good luck

gringo
 
PainIsGrowth said:
Hello Forum,
Thank you very much for providing the right direction to look for finding what is going wrong in my body. I had the recommended blood tests done from this post, done at Quest.
https://thinksteroids.com/community/threads/134254957

Again, here are my main symptoms.
* Zero Libido/Sex Drive
* Bad Erectile Dysfunction even when using max doses of Cialis or Levitra
* Loss of Morning / Spontaneous / Nocturnal Erections
* Penile Tissue Changes (narrowing, shrinkage, curving, numbness, wrinkled)
* Penis Feels "disconnected" from head or body

****Complete loss of pleasure during Orgasm, this is new during last month. I know oxytocin is created by the pituitary, so I'm wondering is something is damaged there? I literally have no sensation during sex/masturbation, a slight sensation at approach of orgasm, and then nothing when there used to be a massive euphoric rush and tingly sensation thoughout my body. This is worrying me the most now.
Here are the results: In Range Out of Range Refererence Range
Estrogens, Fractionated, LC/MS/MS
Estrone, LC/MS/MS 23 pg/ml
Reference Range: < OR = 68

ESTRADIOL, ULTRASENSITIVE 48 H pg/mL
Reference Range: < OR = 29

Estriold, Serem <0.10 ng/mL
Reference Range:
Adults: 0.2 or LESS

Hepatic Function Panel
Only listing things out of range:
ALBUMIN 5.2 H Range : 3.6 - 5.1 g/dL
AST 88 H Range: 10-40 U/L
ALT 81 H Range: 9 -60 U/L

New Testosterone Results, FREE BIO TOTAL LC/MS/MS Range:

Testosterone Total 1081 250-1100 ng/dL
Testosterone Free 127.8 46.0 - 224.0 pg/mL
Testosterone BioAva 301.7 110.0-575.0 ng/dL
SHBG 44 7-49 nmol/L
Albumin Serum 5.2 H 3.6-5.1 g/dL


Estrogens, Total Serum 116 pg/mL Reference Range 130 or LESS

Progesterone, LC/MS/MS .3 ng/mL Reference Range .3 or LESS

PREGNENOLONE 39 ng/dL Reference Range 10-200

Dihydrotestosterone FREE Serum: PENDING, will know tomorrow
ESTRADIOL, FREE, LC/MS/MS PENDING, will know tomorrow

CBC = everything within range

ALDOSTERONE 13 ng/dL

CORTISOL, TOTAL 26.9 mcg/dL H
Reference Range for 8AM (7-9AM) 4.0 to 22.0
Reference Range for 4PM (3-5PM) 3.0-17.0
(I took this bloodtest at 11am, after a stressful situation trying to get the doctor to order these tests)
Range
DHEA Sulfate 302 110-510 mcg/dL
FSH 1.4 L 1.6-8.0 mIU/mL
LH 3.9 1.5-9.3 mIU/mL
Prolactin 8.7 2.0 - 18.0 ng/mL
T-4, Free 1.3 0.8 - 1.8 ng/dL
TSH, 3rd Gen 2.23 0.40 - 4.50 mIU/L
PSA, total 0.8 < or = 4.0 ng/mL

T3, FREE 297 230- 420 pg/dL
**********************************************************************************************
I know its a lot to look at, but I really appreciate anyone's help. I'll post the DHT and free estradiol tomorrow when I get it, but until then, please let me know what you think the most likely cause of these symptoms are. Urologists up to this point offer nothing but cialis, which barely works. Within the last month, the ejaculatory anhedonia is really scary! Is the low FSH with the high estradiol ultrasensitive enough to warrant an MRI for a brain tumor? How can I bring the Estradiol down naturally? Is my LH really "normal", and what causes FSH to be low? My old testosterone and thyroid results were done in June, so if you reference them, thats the date. Thanks again.
Click to expand...

Estradiol high ----> Liquidex 0.75cc/E3D retest in 6 weeks
-----------------------
FreeT low
with your
SHBG=44
you need
TotalT=around 1500 (off the chart
to get there you need over 200mg/week of testosterone
Do 200mg/week on E3D schedule, retest in 2-3 months
do HCG Novarel, 500iu/shot
do both T & hcg shots on same day, E3D schedule, use 30ga 1/2" needle, subq shots around navel for both T& hcg, at the same time take LiquiDex
Goal
FreeT~300 using dr Shippens chart, post #41
https://anabolicminds.com/forum/male-anti-aging/66268-jans-bloodtest-april13-2.html

Do blood testing per post #44
----------------
T3, T4, FREE very low, get up to 4grains Armour Thyroid then start blood testing.
You want both at the top of range. You may be on top of FreeT3 and still be short on FreeT4, will have to use little bit of Synthroid at that time.
Carefull ramping up on Armour, watch pulse and temperatures, do not go over 90bpm resting
-----------------
DHEA low, get 100mg/day, test and adjus dose, you want to be at 500-650
------------------
Get prescription compounded pregnenolone cream, 100mg/mL, use 2grams/day, retest, adjust dose
-----------------------

AST
ALT
 
Last edited:
Thank you for the replies so far. This is definately going to require a good doctor, but looking at the results so far, what are the probable causes of the estradiol (ultrasensitive) being high, considering my bioavailable testosterone is pretty good. Is my free testosterone at 127.8 Does this sound like a possible testicle tumor (leydig) or adrenal tumor. Or does this seem more like thyroid condition with adrenal fatigue? I want to get to the bottom of the cause, and treat from there. I'm guessing im going to need to see an Endocrinologist to begin some treatment. Any recommendations for Florida/Georgia area? Also, my previous testesterone test done in June was

Free Testosterone 202.1 H 35.0-155.0 pg/mL
I was high at 202.1 H, and the range was 35.0 - 155.0 pg/mL

The new test shows
Testosterone Free 127.8 46.0 - 224.0 pg/mL.

Why is there such a different range, since both were done by Quest. The newer one includes bioavailable. Are they comparable, or did they use a more sensitive testing method this time around? If not, my testosterone free almost dropped in half within the last 2 months. Also, will the DHT and Estradiol Free levels, which should definately be in tomorrow, give any other insights into this condition? Thanks again.
phil-
I'll try to test for the CAH next time I get bloodwork, but I think the prolactinoma is ruled out with my prolactin levels, right? Thanks for the ideas.
 
Last edited:
Jan gave you some good info but first things first you need to get your estradiol down then retest. You Free T levels can go up getting your Estradiol down your Total T can come up some 200 to 300 points and your SHBG can come down.
Medibolics
this link is about older men but still applies.
Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels -- Leder et al. 89 (3): 1174 -- Journal of Clinical Endocrinology & Metabolism
So do this first then retest Don't go on TRT or see an Endo Endo's are not good Dr.'s for low T or Adrenals and Thyroid. Read the sticky Finding a New Dr.
 
Re: Dihydrotestosterone, Free, Serum

I just called Quest and got my DHT results. They don't seem to add any more insight into this condition. The results seem in range, and I from what i've read really high DHT or LOW dht isnt good for libido. It seems like the high E2 has to be what's causing this problem! Does anyone know from bloodtest experience if 48 E2 is high enough to completely kill libido and give severe ED? Maybe its different person to person, but im just wondering. Also what are the known physical conditions that cause high E2. I don't care how obscure the reference. I want to eliminate all possibilities.

Value Range
Dihydrotestosterone 53 25- 75 ng/dL
DHT free 4.81 1.00 - 6.20 pg/mL
DHT free % .83 % .62 - 1.10%

Estradiol, Free, LC/MS/MS still pending. Its frustrating for tests to take so long.
 
Some men not me can do good with a level between 30 to 40 but they have a higher SHBG level. I have a low normal SHBG levels about 20 I can not get it up if I am over 30 pg/ml I do best at 15 to 20. When I get over 30 I get a bad rash, have hard and sore nipples, look red on my upper body like a sun burn, sweat and feel hot all day, have panic attacks and bad brain fog.
 
Phil, is that correlation between SHBG and E true for most men? Is it a good guide to go by? My E is 33 and my SHBG is about the same.
 
I don't know a hole lot about it other then what Dr. John told me my SHBG is 20 at the time my E2 was 20 and Dr. John told me my E2 was not low enough so when I got down to 15 wow big difference much better libido and wood.
jaydee said:
Phil, is that correlation between SHBG and E true for most men? Is it a good guide to go by? My E is 33 and my SHBG is about the same.
Click to expand...
 
jaydee said:
Wow.....thats amazing you got such a difference with such a small change.
Click to expand...

This is why it is so dam hard to keep leveled on estradiol the window is dam small and I find the best gauge for this is night time and moring wood when Estradiol is at the best range you get wood so strong it wakes you up. One needs to keep a log on how they are doing day to day. I went to the gym to day and was working out after about 40 mins my nipples started to get dam hard and sore this tells me my E2 is going up but after I got home it settled down.
 
These are the final pending Estradiol, Free, LC/MS/MS results. I'm going to the doctor who ordered them tomorrow, so hopefully, I can use these to show that something isn't right. I highly doubt he would go for the Arimdex, but maybe I could ask for an MRI of the adrenals or pituitary to rule out an estrogen secreting tumor? Don't really know where else to go from here.


Estradiol, Free, LC/MS/MS Range
Estradiol free .91 H .3 - .9 pg/mL
Estradiol free % 1.66 % 1.66% - 2.11 %
Estradiol 55 10-50 pg/mL

I guess this was a seperate Estradiol test from the Ultrasensitive method which came back at 48H. I hope this is enough to get some help.
 
I don't know about doing an MRI looking for a tumor some men just go high there diet estrogins are all around us they pump it into the cattle to get them to hold water it's in the plastic we drink water from every thing you buy at the store has SOY in it this drives up E levels.
Your E2 at 55 is the only test worth anything labs don't say they are running E test on you for women that tells you nothing there just are not tests for E's on men. Dr. John found this out after testing so many men.

If I were you I would keep track of what you eat and drink hell beer has a lot of E's in it. And get on some Zinc with Copper 50 mgs of Zinc to 2 mgs of Copper. This helps a little to keep e2 down if you get some arimidex and your not on TRT be dam carefull you don't drive your E2 down to low this is just as bad as to high.
 
Thought i would chip in and give some input on this one.

It would be good to get an idea of your body fat disruption. What is your weight, height and build like? Would you consider yourself "thick skinned" in the physical sense and do you have any fat around your mid-section/gut area or upper thighs?

Again, here are my main symptoms.
* Zero Libido/Sex Drive
* Bad Erectile Dysfunction even when using max doses of Cialis or Levitra
* Loss of Morning / Spontaneous / Nocturnal Erections
* Penile Tissue Changes (narrowing, shrinkage, curving, numbness, wrinkled)
* Penis Feels "disconnected" from head or body

I have exact same symptoms myself, write down to everything you've written here. Except i have either bad good day's or really bad days with the ED. Curiously have you checked yourself for any testicular abnormalities, particularly on the left side? Any testicular pain (varicocele, hydrococele, sperm blockages, etc)? I would be curious to know how similar our situations are. You never mentioned anything about skin color or texture changes to your foreskin/scrotum? This can be a sign of adrenal fatigue.

Without question i am willing to bet you have adrenal fatigue. High E2 will mimic the same symptoms as hypothyroidism, one of which is low libido and ED. Because thyroid effects every cell in the body including collagen tissue, cell level changes will occur due to low thyroid activity.

Libido (or sexual aggression) comes from a combination fo factors but most noticeably adrenal cortex and thyroid gland. To have a normal libido one needs to have an excess of available energy to perform and finish. Diminished sensation is a sign of low cortisol, which causes interruptions with thyroid hormone delivery and function.

My theory for you right now is that over time your total testosterone increased for some reason. Maybe due to exercise, diet and lifestyle factors. You have probably had high E2 for a long period of time. When a person has high E2 for such a long time, the adrenal cortex is stressed and forced to produce more cortisol to counter-act the effects of estridol on the body.

Due to the increased ATCH production (And demand for cortisol) the body get's stressed and eventually the adrenals tired. When cortisol is low thyroid function is down-graded and free t3 (the active thyroid hormone) can't do it's work properly. Over-time the symptoms of hypothyroidism get worse and worse and cell membranes change to adapt.

Because thyroid controls blood flow (or circulation) around the body, when thyroid hormone is low only the essential bodily functions are supported and thus peripheral body parts (hands, feet, genitalia, etc) get a weaker (And less diluted) blood flow. Because thyroid and adrenals are the major energy sources of the body, all the available energy when exercising, etc is used by the muscles which demand higher blood flow to improve performance, this leads to low thyroid activity on other body part's (including the penis) which will shrink up and impotence, low libido and so fourth will set in. When a person resumes a relaxed state for 15/30 minutes it's normal for the flaccid size to return or with the presence of heat to trigger a stress like response to allow blood flow to the genitalia.

Viagra won't work because of high E2/estridol which is making thyroid so out of whack and down regulating thyroid hormone function. The cascade of events due to high estridol are stressing the adrenals, eventually leading to adrenal fatigue (probably about zone 4/5 right now) and leaving you with no sex drive and chronic impotence.

To aggrevate matter's worse, cortisol can be counter-acted by high testosterone levels which can counter act the effects of cortisol.

When low thyroid occurs digestion problems occur and absorption of important minerals, vitamins and such like are all down regulated. This usually lead's to low Vit B12 and B6 which are important in libido, sensation, nerve function, etc. This will further aggrevate ED problems.

Libido, erections and orgasm are actually stresses to the body and when "stress hormones" are low (cortisol for example) then the body's main reaction is to shut down what isn't needed to keep you alive. Your body has most likely went into a fight or flight response mode.

I feel you are going to need to put your body into manual drive from now and treat adrenals, thyroid and sex hormones. Your testicles are fully functional (unlike mine) which is a bonus on your part.


Testosterone Total 1081 250-1100 ng/dL
Testosterone Free 127.8 46.0 - 224.0 pg/mL
Testosterone BioAva 301.7 110.0-575.0 ng/dL
SHBG 44 7-49 nmol/L
Albumin Serum 5.2 H 3.6-5.1 g/dL

If you had time to read my testicular vs thyroid function research you will notice that increasing Free T3 in almost all cases doubles free testosterone and would help in better regulating sex hormones. Due to better absorption of vitiamens and minerals, zinc, b12 and so fourth would be taken better by your body further helping with the high estridol problem.

I don't feel focusing on sex hormones is important, adrenal and thyroid are the main problem here.

CORTISOL, TOTAL 26.9 mcg/dL H
Reference Range for 8AM (7-9AM) 4.0 to 22.0
Reference Range for 4PM (3-5PM) 3.0-17.0

We really need a real world example of your cortisol readings. A 4x saliva reading would be allot better here. Needle stress, problems with the doctor, etc could have elevated this.

DHEA Sulfate 302 110-510 mcg/dL
FSH 1.4 L 1.6-8.0 mIU/mL
LH 3.9 1.5-9.3 mIU/mL
Prolactin 8.7 2.0 - 18.0 ng/mL
T-4, Free 1.3 0.8 - 1.8 ng/dL
TSH, 3rd Gen 2.23 0.40 - 4.50 mIU/L
PSA, total 0.8 < or = 4.0 ng/mL

TSH look's elevated, in fact the exact same as mine (2.3/2.5). Your body is in demand for thyroid hormone. Free T4 could be higher, but not abnormally low like mine.

FSH seem's low which can be a sign of thyroid problems due to thyroid function controling fertility and sperm production process.

T3, FREE 297 230- 420 pg/dL

This is low, like mine. This should be at the top end of the range.

Dihydrotestosterone 53 25- 75 ng/dL
DHT free 4.81 1.00 - 6.20 pg/mL
DHT free % .83 % .62 - 1.10%

These values appear normal.

Let me think more about this, but we need a proper saliva test to check your daily cortisol production. For example cjones (on this forum) had a high morning cortisol but very low daytime, afternoon and nighttime cortisol reading. So his problems are primary adrenal fatigue resulting in identical symptoms to us.

Treating adrenal and thyroid first would be the best plain of action. Ignore estridol until free testosterone and thyroid hormone can work properly.
 
Thank for the reply!

It would be good to get an idea of your body fat disruption. What is your weight, height and build like? Would you consider yourself "thick skinned" in the physical sense and do you have any fat around your mid-section/gut area or upper thighs?

I currently weight about 150 lbs, and I am about 5'10''. I have pretty low body fat, and can see my abs if I flex. Still im not 6-8% anymore, probably around 10%-12%. I don't have any areas of fat anywhere else, but I did develop a little more heaviness in my face over the last couple years.

Curiously have you checked yourself for any testicular abnormalities, particularly on the left side? Any testicular pain (varicocele, hydrococele, sperm blockages, etc)? I would be curious to know how similar our situations are. You never mentioned anything about skin color or texture changes to your foreskin/scrotum? This can be a sign of adrenal fatigue.

Actually I do have a hydrococele or spematococle, found on an ultrasound. The doctors told me it should not effect anything in my body. Don't really have any pains from them. I did have the darkening of skin forskin, and it has dried out a lot since these symptoms began.

Because thyroid controls blood flow (or circulation) around the body, when thyroid hormone is low only the essential bodily functions are supported and thus peripheral body parts (hands, feet, genitalia, etc) get a weaker (And less diluted) blood flow.

Within the last couple months, along a loss of sensation at orgasm, I also have had extremely sweaty palms and cold feet regardless of the environment. I never had these issues before either, so I doubt it is unrelated.
 
I'm watching this thread like a hawk. My symptoms are identical with the added benefit of my hair thinning. The penile atrophy is what caught my eye because i thought this was a testosterone problem... It would make more sense if it was thyroid because of the blood flow factor.

I definitely notice the atrophy a lot more right after i exercise and when i wake in the morning. My penis slowly begins to "fill up" and regains life later during the evening.
 
Could everybody experiencing this shrinkage, low libido and/or ED problems please answer these questions. I am trying to build a proper theory on what's going on.

1) Can you explain your flaccid shrinkage? Does your penis literally shrink up into nothing? When is the shrinkage worse? What helps recover a normal flaccid size? Any particular time of day, activity, etc? Have you ever experienced what look's like an hour glass shaped flaccid penis (thinning at the top or middle and looking off/out-of-shape)? Does anyone here get the impression there penis has lost (or gained) more elasticity's in the tissues?

2) Do you find sleeping helps at all to regain a short libido burst and improved erection quality? Do you ever get nocturnal erections or morning erections?

3) Have you noticed any actual erectile length or girth changes?

4) Do you find your penis, scrotum have literally no control anymore of temperature? Do you find your scrotum retracting and feeling tight allot?

5) Can you explain the dry skin you are experiencing (if any)? Is it worse after orgasm? Do you get the impression of your skin "shedding" for lack of a better word on your scrotum/penis?

6) Do you suffer a complete lack of sensation in your whole penis? Does this extend to your scrotum/testicle area?

7) Do you ever experience pain or discomfort in this area of your body? Even tingling sensation in the penis/foreskin, etc?

8) Do you have any other symptoms like dry skin around your body, weight gain, mood changes, etc? How would you assess your energy levels and such like.

9) How did you react to viagra/cialis? Did it help with the shrinkage or hinder it further?

10) Has anyone noticed changes to the scrotum and/or testicles?'
 
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