Peptide Purchasing Strategies

[Kendog]

I’ve began to purchase peptides in large quantities mainly from the more popular sources such as HYB and WWB etc but more recently have been exploring the possibility of purchasing the raw powders alone to a) save money and b) make it easier as I want to add into my own vials.

The one thing I am either underestimating or over complicating is surrounding the filler materials / excipients. If I buy raw materials I anticipate it will be 100% raw product, and from the likes of HYB will include some form of excipients mixed with the raw product.

Is anyone able to assist or have any experience doing this and confirm whether there’s a science to the above or is it more straight forward as it appears? I compared a vial of 10mg and 40mg MOTS C and the volume of product included seems compatible hence the question.

 

[AllbrandNew]

Don't pretty much all peptide raws need to be lyophilized (sp?) still?

 

[rxzed]

I’ve began to purchase peptides in large quantities mainly from the more popular sources such as HYB and WWB etc but more recently have been exploring the possibility of purchasing the raw powders alone to a) save money and b) make it easier as I want to add into my own vials.

The one thing I am either underestimating or over complicating is surrounding the filler materials / excipients. If I buy raw materials I anticipate it will be 100% raw product, and from the likes of HYB will include some form of excipients mixed with the raw product.

Is anyone able to assist or have any experience doing this and confirm whether there’s a science to the above or is it more straight forward as it appears? I compared a vial of 10mg and 40mg MOTS C and the volume of product included seems compatible hence the question.

Unless you plan on becoming a seller, or have access to lyophilization equipment, it won't be cheaper.

 

[Kendog]

Unless you plan on becoming a seller, or have access to lyophilization equipment, it won't be cheaper.

Thanks.

I did suspect that could be the case but keen to educate myself further on the feasibility of moving towards that.

 

[trytryagain]

You'd need a pharma-level freeze dryer, one that has the multi-point temperature probes and the ability to push-seal the tops before re-pressurizing at the end of the run. $8k and up ($100ks) for reliable equipment, at least outside of China.

You'd also need the temperature/pressure curves to program into the machines for various source peptide API + solutions combinations.

For peptides, only a very dedicated hobbyist or risk-taking high-volume reseller would look at the cost outlay of lyophilization and be ok with it. Of course there are also cranks/frauds reselling peptide powder domestically to unsuspecting buyers who won't have a safe way to make an injectable out of the product (or are being told it is orally bioavailable, which is only true for for 2 or 3 very specifically engineered peptides).

Slow but straightforward description by a practitioner (lab work, not manufacturing, not concerned with sterility in their context, I think):

View: https://www.youtube.com/watch?v=kqs1uagGlZM


First of four 1-hour presentations on one company's best practices at optimizing the lyophilization processes for other manufacturers and their products:

View: https://www.youtube.com/watch?v=7O7ttxynQmQ


Edit: here's a shorter video, specifically on an extremely large lyophilization device, giving the basics, but with nice animated graphics:

View: https://www.youtube.com/watch?v=4W3sBjQMZzA


TTA