pharma vs generic HGH, side effect difference

[clearheaded]

while its possible some bioactive compounds are different in generic that are undetectable without perhaps crystallography, I think its possible some other explanations may have been overlooked.

Is it just me or folks on pharma use 1/2 dose and then say 'pharma has less sides', or I was told need 2x amount as pharma for effect etc etc.. that being said, It struck me, there may be an answer for same dose differences in sides. It seems like pharma often has a greater volume of llypholized powder, now while hgh remains the same, the increase in (at least in my passing observation, those with more pharma can chime in) volume is likely from higher volume of mannitol. mannitol of course is pretty decent diuretic, meaning it could counteract sides like fluid retention carpal tunnel etc. so very possible a couple things at play, higher dose for longer with generics along with less mannitol causing some subjective differences some people note...

yes I understand for edema and other severe swellings mannitol is given at 10s of grams dosage but perhaps enough to help with minor sides, or perhaps other alcohol sugars are used in pharma preparations with strong diuretic properties depending on brand... glycine for example has slight anti inflammatory action and reduces BP, or sodium phosphate causing more water to enter the bowel which of course reduces water retention. all are included in pharma hgh. so it seems at least plausible low dosages of these COULD help reduce sides particularly when together.

 

[lilhawk]

Greater volume of lyophilized powder? A puck of Serostim is half the size of any puck of generic GH I’ve ever seen, and it has 18 iu in it compared to 10 iu of generic. Mannitol is used as a preservative to maintain the integrity of the GH in lyophilized form and does not have diuretic properties in the quantity that is used for preservation of the powder. If it did have diuretic properties then it would have to be listed as a combo drug like some blood pressure meds are.

 

[Liska]

Start treating Meso like a library and you'll find that we've had this discussion many times over the years, addressing all of the points you're speculating about. @lilhawk is correct basically.

 

[clearheaded]

interesting about serostim, I guess I was talking more about Geno as regarded as less sides for pharma if I am not mistaken.

also yes mannitol is a diuretic lol used for this purpose DAILY.. wether intentional or not several of ingredients have properties that reduce sides.

Mannitol injection Uses, Side Effects & Warnings

Physician reviewed mannitol injection patient information - includes mannitol injection description, dosage and directions.

www.drugs.com

@Liska thanks, glad folks have discussed this before(newbs be newbs). when use multiple diuretics/drugs at lower doses u still get SMALL effect ie cumulative ie taking small sub effective amount of ibuprofen ketoprofen Tylenol together you will get larger anti-inflammatory/pain relieving property even though each is below "effective dose" . I guess the best way to settle that is get a COA of contents of generic HGH and see what additives they have. IF have same additives then obv not that BUT if have different additives, then perhaps there is something to it. I also would guess diuretic properties act different in different people depending on their sodium potassium levels.

 

[Liska]

I guess the best way to settle that is get a COA of contents of generic HGH and see what additives they have.

Already done all that and posted HGH raw labtests last year which confirmed the API:excipient ratios stated in said COA's. If it was this obvious, we'd have figured it out long ago. If such a difference does exist, it's hidden within a variable we have no practical means of testing for.

 

[clearheaded]

interesting, so they found glycine and sodium phosphate in generic HGH? along with the obvious mannitol. or are u talking API as pure somatropin vs additives as API?

 

[Liska]

interesting, so they found glycine and sodium phosphate in generic HGH? along with the obvious mannitol. or are u talking API as pure somatropin vs additives as API?

API as in pure somatropin before addition of excipients. I assume you looked at fillers in Genotropin and other pens? I found it more beneficial to compare lyophilized powder in vials (Serostim, Jintropin, Ansomone etc) to their generic counterparts regarding excipients rather than comparing them to HGH pens/carts, which usually contain a wider variety of excipients by necessity.

No matter how you look at said compositions, the amounts of mannitol or sucrose and certainly of the excipients not even exceeding a single milligram per injection remain insignificant.

 

[GuerillaPete]

API as in pure somatropin before addition of excipients. I assume you looked at fillers in Genotropin and other pens? I found it more beneficial to compare lyophilized powder in vials (Serostim, Jintropin, Ansomone etc) to their generic counterparts regarding excipients rather than comparing them to HGH pens/carts, which usually contain a wider variety of excipients by necessity.

No matter how you look at said compositions, the amounts of mannitol or sucrose and certainly of the excipients not even exceeding a single milligram per injection remain insignificant.

The difference could be that it is injected vs ingested .
Did you guys think of that as well when saying its insignificant?
Im not stating anything just asking .

 

[Liska]

The difference could be that it is injected vs ingested .
Did you guys think of that as well when saying its insignificant?
Im not stating anything just asking .

I've not looked at ingestion at all tbh. These excipients are not exclusive to pharmaceutical/generic HGH either but used in pharma and generic HCG, in peptides and many other products made for injection, though some of them like HCG elicit side effects like water retention anyways.