I first started out with serostim for about 7 months, running 4iu per day. Sides were ridiculous for the first 3 months, and I started out at 2iu. From there I switched to greytops and started right off the bat at 4iu and got numbness again in my hands for a while, but I just kept rocking on at 4iu. Sides didn't last but a few weeks. Ran those for about 4 months and then switched to the blacks. Still taking 4iu and didn't get any sides when I switched to them. But I'm still seeing results as far as fat loss, or keeping the fat off. I just don't see any need at going any higher with my doses. I'd rather up my test or tren dose. That has a far greater effect on progress than upping the GH dosage, unless you add slin to the mix, which I won't.