Estrogen receptor gets a little fucked up from master after long use at high dosage ,
i was on for most of the year starting at 350 ending at about 500mg of mast and about 1g of test.
At the end of this "cycle" I started to get low estrogen sides like complete lack of emotions and joint pain
After dropping mast and going to a test cruise, i got all sorts of random pains from joints to even gum/teeth pain...like I had very slight opioid withdrawal..... Most likely I killed my estrogen receptors and it took a long while to feel normal
So for like anything in this game it is very complicated and individual dependent...I would not imagine running 500 test with 1g of mast like some do...