pre-workout Arginine REDUCED GH response?!

[Jeton]

Oral arginine attenuates the growth hormone respon... [J Appl Physiol. 2006] - PubMed result


J Appl Physiol. 2006 Sep;101(3):848-52. Epub 2006 Jun 1.
Oral arginine attenuates the growth hormone response to resistance exercise.

Collier SR, Collins E, Kanaley JA.

Dept. of Exercise Science, Syracuse University, Syracuse, NY 13244, USA.
Abstract

This study investigated the combined effect of resistance exercise and arginine ingestion on spontaneous growth hormone (GH) release. Eight healthy male subjects were studied randomly on four separate occasions [placebo, arginine (Arg), placebo + exercise (Ex), arginine + exercise (Arg+Ex)]. Subjects had blood sampled every 10 min for 3.5 h. After baseline sampling (30 min), subjects ingested a 7-g dose of arginine or placebo (blinded, randomly assigned). On the exercise days, the subject performed 3 sets of 9 exercises, 10 repetitions at 80% one repetition maximum. Resting GH concentrations were similar on each study day. Integrated GH area under the curve was significantly higher on the Ex day (508.7 +/- 169.6 min.ng/ml; P < 0.05) than on any of the other study days. Arg+Ex (260.5 +/- 76.8 min.ng/ml) resulted in a greater response than the placebo day but not significantly greater than the Arg day. The GH half-life and half duration were not influenced by the stimulus administered. The GH secretory burst mass was larger, but not significantly, on the Arg, Ex, and Arg+Ex day than the placebo day. Endogenous GH production rate (Ex > Arg+Ex > Arg > placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P < 0.05) but there were no differences between the Ex and Arg+Ex day. Oral arginine alone (7 g) stimulated GH release, but a greater GH response was seen with exercise alone. The combined effect of arginine before exercise attenuates the GH response. Autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope.

PMID: 16741262 [PubMed - indexed for MEDLINE]Free Article

 

[Jeton]

i guess this means i'll have to divorce my Juven from my pre-workout drink, n add GABA instead...

 

[TrainHard]

Hey

Here is the full artiicle for ya.

 

[Jeton]

Hey

Here is the full artiicle for ya.

much obliged, TH...the full text does elaborate the issue nicely. given my age (38) it appears my GH attenuation from ingesting arginine b4 exercise would be less severe than of the younger guys in the study, but it's still something to avoid.

seems the big difference is swallowed vs injected arginine, as the latter didnt seem to have this problem n in fact released more GH when injected 30 min prior to exercise.

who the hell is gonna inject 30 grams of arginine intravenously 30 min b4 every workout??

 

[TrainHard]

The results were very interesting, no one is going to Inject arginine, or even have that access to that much for that purpose. I was expecting the results to be a bit closer, but it clearly shows exercise alone will increase GH higher and for a longer period of time tha with arginine.

While I could never afford to take arginine in the doses they describe, I don't think the small little bit in my pre workout is not going to affect my level to much.

One thing back about 5 years ago that was big was adding Peptide bonded Glutamine to protein drinks before bed for an increased GH response. Still not sure if that's still the case today. But would be worth looking back into.

much obliged, TH...the full text does elaborate the issue nicely. given my age (38) it appears my GH attenuation from ingesting arginine b4 exercise would be less severe than of the younger guys in the study, but it's still something to avoid.

seems the big difference is swallowed vs injected arginine, as the latter didnt seem to have this problem n in fact released more GH when injected 30 min prior to exercise.

who the hell is gonna inject 30 grams of arginine intravenously 30 min b4 every workout??

 

[Jeton]

The results were very interesting, no one is going to Inject arginine, or even have that access to that much for that purpose. I was expecting the results to be a bit closer, but it clearly shows exercise alone will increase GH higher and for a longer period of time tha with arginine.

While I could never afford to take arginine in the doses they describe, I don't think the small little bit in my pre workout is not going to affect my level to much.

One thing back about 5 years ago that was big was adding Peptide bonded Glutamine to protein drinks before bed for an increased GH response. Still not sure if that's still the case today. But would be worth looking back into.

http://www.ncbi.nlm.nih.gov/pubmed/18091016

as i wrote in another thread, i'm thinking GABA's gonna do a better job itself...

 

[TrainHard]

Growth hormone isoform responses to GABA ingestion... [Med Sci Sports Exerc. 2008] - PubMed result

as i wrote in another thread, i'm thinking GABA's gonna do a better job itself...

Gaba has good research following what it does, however, Have you ever taken a large dose of Gaba before?? Around 3 grams?? You'll be in for a big surprise. That's why I've had a hard time using it. Maybe just a little bit before sleep, but its been years since I've done that.