MESO-Rx Sponsor Primal Pharma - US Domestic

[Ghoul]

@Turkeybuilder and @BigDadd7. Not disagreeing with either of you. I’m just suggesting @monster8912 looks it up since it sounds like he hasn’t tried Cialis before. It hits me later sort of like @ackmack78 said.

Yes, onset time is 1/2 hour. Both Viagra and Cialis start working in 1/2 hour. Please check the peak effect time though.

Viagra peaks in 1 hour. Cialis peaks in 2 hours (some say 3 but idk about that). I’m not trying to say Cialis takes days to work or something like that. It just takes a little longer than Viagra.

Also, It’s absolutely wild how many different times I’ve saw when researching cialis. I’ve saw 1/2 hour, 2 hours, 12-14 hours (ridiculous) and 3-5 days (ridiculous).

I take 10mg of Cialis every morning before I go to the gym. I do use it as a pre-workout.

"On demand" Cialis sucks. Half the time it starts working the next fucking morning. Daily low dose is awesome, always ready to go; and a bunch of other benefits.

Viagra is reliably fast acting, but fuck that shit and the "Blue shift" in vision that makes everything look ugly like it's lit by police station cheap fluorescent lighting, and the sinus headaches. No thanks. Better to deal with the sides from the first few weeks of daily Cialis until they go away, than sides every time with Viagra.

If you're not going daily Cialis, Avanafil is much better than Viagra and worth the higher price to avoid Viagra's sides.

 

[Tbaz192]

PT-141 fires up Libido, and is FDA approved for that purpose, bizarrely, only for women.


View attachment 355830

Careful yall she’ll wanna put it in your butt. She’ll have a crazy libido.
Make sure you’re on Tren. Jk.
(Good stuff tho I’ve heard)

 

[Oldhand]

No, both are PDE5 inhibitors (increasing Nitric Oxide in blood vessels, allowing for easier relaxation and blood flow), with somewhat different mechanisms of action. They only work on the "plumbing". Daily low dose cialis also protects long term health, maintains exercise capacity, while reducing cardiovascular disease, cognitive decline, and all cause mortality. ]

PT-141 fires up Libido, and is FDA approved for that purpose, bizarrely, only for women.


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I bet it’s so the companies have something to market exclusively towards women. They double their clients without cutting into Viagra sales.

 

[Photon]

I remember this vendor talking about adding batch numbers to their vials.
Anyone knows what happened to that?

 

[Ghoul]

I bet it’s so the companies have something to market exclusively towards women. They double their clients without cutting into Viagra sales.

I don't get it. Viagra is a cheap generic no one makes money on (it's literally 1¢ / pill wholesale).

Vyleesi is like $300 per dose, $1200 for 4 pens, is pretty much cash pay only. and everyone knows it works for men. I don't get why they don't offer it. Even at that crazy price, men would line up for intensified pleasure it offers. The right dose will make you so horny it'll punch through almost any ED purely psychologically!

They've used PT-141 to allow men with severe spinal cord injuries to get so psychologically horny the brain literally carves an "alternate path" through remaining working nerves to restore sensation signals from the penis. It's that potent at the correct dose (which is much higher than most use).

 

[Elektrobot]

Daily low dose cialis also protects long term health, maintains exercise capacity, while reducing cardiovascular disease, cognitive decline, and all cause mortality. ]

Are these things not attributed to viagra use? I don't get sides from viagra. I use a 20mg sildenafil tablet pre-workout every day for pump, but it would be nice to have the other health benefits you mentioned.

 

[Ghoul]

Are these things not attributed to viagra use? I don't get sides from viagra. I use a 20mg sildenafil tablet pre-workout every day for pump, but it would be nice to have the other health benefits you mentioned.

Both are PDE-5 (natural enzyme which destroys nitric oxide) inhibitors (keeping No2 around, good for blood vessels).

But there are 2 reasons Viagra doesn't work as a daily:

Viagra's half life of 4 hours vs Cialis 18 hours means you have to take it multiple times a day to maintain steady levels.

Viagra is less tissue selective than Cialis. Because of this "sloppiness", it acts as a PDE-6 inhibitor, which is important for eye health. If taken multiple times a day, long term, it would accumulate in the retina at levels that would become toxic to your eyes:

 

[Elektrobot]

Both are PDE-5 (natural enzyme which destroys nitric oxide) inhibitors (keeping No2 around, good for blood vessels).

But there are 2 reasons Viagra doesn't work as a daily:

Viagra's half life of 4 hours vs Cialis 18 hours means you have to take it multiple times a day to maintain steady levels.

Viagra is less tissue selective than Cialis. Because of this "sloppiness", it acts as a PDE-6 inhibitor, which is important for eye health. If taken multiple times a day, long term, it would accumulate in the retina at levels that would become toxic to your eyes:

Thank you for sharing all of this. Especially the eye concerns. I'll message my dr and ask for a Cialis prescription.

 

[powdered_toast_man]

They've used PT-141 to allow men with severe spinal cord injuries to get so psychologically horny the brain literally carves an "alternate path" through remaining working nerves to restore sensation signals from the penis. It's that potent at the correct dose (which is much higher than most use).

Being that horny seems really unpleasant, like having the worst bug bite in the center of your back. Definitely something to take only if your partner is working. I can't imagine the average forum goer's 55yr old wife wants him to prematurely ejaculate in her 15 times in one day Just bc he took too much PT141.

 

[Ghoul]

Being that horny seems really unpleasant, like having the worst bug bite in the center of your back. Definitely something to take only if your partner is working. I can't imagine the average forum goer's 55yr old wife wants him to prematurely ejaculate in her 15 times in one day Just bc he took too much PT141.

Yeah I tell newbies have a willing partner or a private space booked for 12 hours the first time you try 2-3mg lol.

 

[AllGoodThings]

I really wish I could handle tadalafil, but even 5mg/day gives me unreal heartburn. I pushed past it to see if it resolved, but months later, it was still there every fricking day. I went through way too much pepto bismol during that time.

 

[Earthworm Jim]

Worth a shot, and you should be doing it anyway tbh. Zone 2 cardio is your friend. I do incline treadmill every day at a brisk pace for 30-45 minutes. Normally shoot for ~135bpm. Yes, it is fucking mind numbingly boring. No, it does not get more enjoyable. YMMV.

Same here. At that heart rate from incline I can read a book without bouncing around too much. Makes me forget the time. Looking at the timer is the limiting factor in my cardio.

Another trick I like to do some days to push the intensity is go up or down in speed in intervals of 0.1 each minute

 

[Earthworm Jim]

Do you find this hinders your leg recovery. I'm trying to do the same. BUt an assault bike, was doing manual type hiit before that with sprints/jumping jacks/jump rope but it seems like it taxes my legs more than I want.

That's why I decided to have a season for focusing on max for part of the year and a season for focusing on sprints and less intensity on the squats/deadlifts

 

[Earthworm Jim]

Yeah I think my leg days are still pretty good, my legs just feel beat up all week. Still trying to get the programming sorted. The echo bike/assault bike gives me a nasty quad pump right off the bat. But I do love the thing.

Do you take glutamine

 

[watchtymeflyyy]

@Primal_Pharma what’s the word on the MENT testing? I think Jano has had it for a bit now.

 

[Photon]

I really wish I could handle tadalafil, but even 5mg/day gives me unreal heartburn. I pushed past it to see if it resolved, but months later, it was still there every fricking day. I went through way too much pepto bismol during that time.

I can't use it either.
Low dose turns me into a lobster.
I continued using it and it gave me massive nose bleeds.

 

[Primal_Pharma]

@Primal_Pharma what’s the word on the MENT testing? I think Jano has had it for a bit now.

It’s stuck in a warehouse in the Czech Republic waiting to get cleared, brother. Nothing we can do but wait.

 

[Photon]

It’s stuck in a warehouse in the Czech Republic waiting to get cleared, brother. Nothing we can do but wait.

Batch numbers on vials?
Scrapped?

MESO-Rx Sponsor Post in thread 'Primal Pharma - US Domestic'

Sep 7, 2025

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EQ is following right behind. Expect that to land about a week after the Test E/U drop.

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[CHIEF M]

No, both are PDE5 inhibitors (increasing Nitric Oxide in blood vessels, allowing for easier relaxation and blood flow), with somewhat different mechanisms of action. They only work on the "plumbing". Daily low dose cialis also protects long term health, maintains exercise capacity, while reducing cardiovascular disease, cognitive decline, and all cause mortality. ]

PT-141 fires up Libido, and is FDA approved for that purpose, bizarrely, only for women.


View attachment 355830

I have those in lozenges version from my TRT clinic

 

[manbat]

Consider this an official request for PT-141.
Gotta hornmaxx.