PVDF VS PTFE

bayleyt

New Member
Hi all,

I have been using PVDF for a while but I see people suggesting PTFE or other filter types. Is there a specific filter type between these two that is more appropriate?

Also, if anyone has any brand names they are partial to I'd appreciate the input.

Thanks!
 
Does it change anything ?

Yes, it does.

I'm not sure which specific syringe filter you're looking at on Amazon, but the first one that I can find has this title: "Sterile Syringe Filter PTFE Hydrophobic Filtration 0.22 um Pore Size, 25 mm Membrane Diameter, 20 Pack, Sterile Packed Individually for HPLC Sample Preparation"

It's sold by "PEKY BIOTECH" and says explicitly on the packaging "For Lab Use Only". There's nothing to suggest they could be used in the preparation of parenteral compounds.

I figure there's a high probability that they are fine, probably sterile, probably PTFE as advertised, and probably hydrophobic, but there's no guarantees.

When I refer to a "reputable" producer of syringe filters, I'm thinking of companies that manufacture and sell filters that adhere to USP standards for sterility and particulate matter as well as ISO standards for sterilization.

In my case, it change the degree to which I trust the producer. I filter all my gear, but I also have faith that my gear is also sterile. There's no reason to believe that it's not, but I have no guarantee nor chain of trust to prove that it is. As such, if I want that guarantee, I'll filter, and I'll do so with a filter that offers that increased level of trust, which is something I'm willing to pay for.

From my perspective, filtering UGL gear that's sterile based on faith with a filter the characteristics of which are based on faith buys me little extra reassurance.

If you take the probability of either being sterile and model them as such:

Pfinal=P1⋅P2+(1−P1)⋅P2

You find that adding the filter with anything less than 100% confidence does little to improve the risk.
 
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