Rektest - Death is available log

[Ghoul]

Yep, hopefully straight to my buttocks with the leg workout Im gonna do tomorrow,
Can never have enough for the girls to grip lol


Oh, I 100% beat the piss out of the Tirz.. Im surprised no one here told me off or noticed how fast I tiered up on dosage with it.
Im at a point with 20MG where it doesn’t really affect me anymore, gastric slowing.
Its maintaining 195. I have a choice of chilling or going into the unknown of above 20MG, 22.5mg 25mg @Ghoul thoughts?

Actually havent been sick in a while, I mean I throw up if I eat too much but besides that nope.

I switched from feeling nothing maintenance dose 20mg QSC back to pharma 15mg, and it was like I upped the dose by 50%. All the sides at max, Struggling to not lose 4lbs a week. Have to be really careful eating on pin day or will end up getting really sick from the "retroactive punishment" glps give you if it kicks in while you still have food in your system from prior to increasing the dose.

So based on that, if you're looking to lower your weight further, I see no issue going up to as much as 30mg if you need to. It's definately not a 1:1 equivalent with pharma. Could be immunogenicity weakening it, but if that's the case, it's not causing a crossover immunity to pharma.

 

[PaintDrinker]

I switched from feeling nothing maintenance dose 20mg QSC back to pharma 15mg, and it was like I upped the dose by 50%. All the sides at max, Struggling to not lose 4lbs a week. Have to be really careful eating on pin day or will end up getting really sick from the "retroactive punishment" glps give you if it kicks in while you still have food in your system from prior to increasing the dose.

So based on that, if you're looking to lower your weight further, I see no issue going up to as much as 30mg if you need to. It's definately not a 1:1 equivalent with pharma. Could be immunogenicity weakening it, but if that's the case, it's not causing a crossover immunity to pharma.

Very intrigued by this. You believe pharma is superior with glps? I think there’s something to this. I’m on roughly 20mgs generic and can still eat. Adding Sema .5 a week crushed the appetite. My assumption is was just tolerance build up but now you have me thinking about the pharma route. I get nasty sides from Sema

 

[Ghoul]

Very intrigued by this. You believe pharma is superior with glps? I think there’s something to this. I’m on roughly 20mgs generic and can still eat. Adding Sema .5 a week crushed the appetite. My assumption is was just tolerance build up but now you have me thinking about the pharma route. I get nasty sides from Sema

I once made the mistake of trying to add .50 mg Sema while on 15mg UGL Tirz, and it destroyed me. I have been on 2.4mg Sema before Tirz and it was no issue. 15mg Tirz seems weak by comparison, but that tiny amount of Sema added to Tirz wrecked me for days. That's when I went to 20mg Tirz, which increased the appetite suppression in a much more tolerable way.

UGL GLP's are synthesized, not recombinant from DNA inserted into yeast like pharma. They don't appear quite as "natural" to the immune system and it's very possible they're being identified as foreign bodies, and removed, lessening their effectiveness.

The FDA addressed this at the October meeting of the Compounding Pharmacy Advisory board.



Without getting into the details, immune response to peptides is always present, but above all certain level it starts weakening the effectiveness of the drug. If it's high, that weakening impact on the drug can build and get progressively worse over time.

Look at the immune response to pharma GLPs, on the left of each chart vs the two compounded GLPs on the right.

On a side note, the chart on the right shows how much that immune response is lessened after filtering. One of the two compounded (ie, legal UGL) GLPs had a 80% reduction in immune response.

 

[mochul]

I once made the mistake of trying to add .50 mg Sema while on 15mg UGL Tirz, and it destroyed me. I have been on 2.4mg Sema before Tirz and it was no issue. 15mg Tirz seems weak by comparison, but that tiny amount of Sema added to Tirz wrecked me for days. That's when I went to 20mg Tirz, which increased the appetite suppression in a much more tolerable way.

UGL GLP's are synthesized, not recombinant from DNA inserted into yeast like pharma. They don't appear quite as "natural" to the immune system and it's very possible they're being identified as foreign bodies, and removed, lessening their effectiveness.

The FDA addressed this at the October meeting of the Compounding Pharmacy Advisory board.

View attachment 305567

Without getting into the details, immune response to peptides is always present, but above all certain level it starts weakening the effectiveness of the drug. If it's high, that weakening impact on the drug can build and get progressively worse over time.

Look at the immune response to pharma GLPs, on the left of each chart vs the two compounded GLPs on the right.

On a side note, the chart on the right shows how much that immune response is lessened after filtering. One of the two compounded (ie, legal UGL) GLPs had a 80% reduction in immune response.

Can you filter the qsc vials next time and compare them again?

 

[Ghoul]

Can you filter the qsc vials next time and compare them again?

I filter all my peptides now, and observed dramatic differences in some, and nothing noticeable in others (though I'm convinced there are still benefits).

I keep a 6 month "buffer" supply of the pharma pens, but as soon as Zepbound is once again out of stock, as I'm sure it will be, I'll be back to UGL and see if filtering makes a difference. In the meantime I'll try to get GLP and GIP antibodies tested, as that's really going to tell the story.

 

[RekTest]

I filter all my peptides now, and observed dramatic differences in some, and nothing noticeable in others (though I'm convinced there are still benefits).

I keep a 6 month "buffer" supply of the pharma pens, but as soon as Zepbound is once again out of stock, as I'm sure it will be, I'll be back to UGL and see if filtering makes a difference. In the meantime I'll try to get GLP and GIP antibodies tested, as that's really going to tell the story.

Is there a write around here on how to properly filter?
I need to learn how to do this, what to buy etc

Are you getting pharma pens here?

 

[iris]

Is there a write around here on how to properly filter?
I need to learn how to do this, what to buy etc

Oooohhhh, look now.
He is filtering stuff.

And what was your response when I asked you to please filter the stuff you inject?
Now Ghoul turns up and it's all change.
Let's see if that npp is going to get filtered, too.
Thank you for taking your office CEO into consideration, you know.
Nevermind, + 1 for thinking about this.

Notwithstanding this change of perspective, the blatant disregard you have displayed towards your very own CEO will necessarily lead to your ousting from the board of directors.
Unappealable, currently. Xmas is coming and we may be of a more lenient disposition. Maybe.

 

[RekTest]

I just opened my music app to this, the last song I was playing at 8am before I got out of the truck this morning.
Stopped dead in my tracks.



View: https://youtu.be/cPM9pRqYTVQ?si=07y7tU6mCumvflql

 

[iris]

❤