Reta Advice

[seelos]

I injected 2mg reta last week on friday and i've been feeling terrible since, monday night and tuesday night at 2 am exactly I've suddenly started waking up from my sleep uncontrollably vomiting everywhere. Of course aside from that having many other sides such as sulfur burps, regular nausea, diarrhea, absolutely zero appetite (getting 1000 calories or less daily), no energy, etc.

At this point i've already decided that I won't be injecting again this coming friday to let my stomach rest and recover, but could I get some advice on how to get back into it? I was thinking I'd wait a week until next friday and then inject 1mg.

Reta has been awful for me so far but based on how terrible these sides have been I can see its very potent I don't want to just stop it alltogether. Let me know what I should do to allow myself to recover and how to reintroduce it.

 

[seelos]

I've been using Lobster Reta (purple caps) for several months with no issues. It is possible that you've had an unusually bad reaction; I've had sulfur burps here and there on Reta and also a substantial increase in RHR (more than 10-15BPM) at 4mg, but nothing else really. I'm currently on 4mg/wk (divided into 3 shots).

My older sister has been through similar symptoms to yours on a starting dose of pharma Mounjaro.

that’s good insight thank you. did you also start out on the 2mg dose? why do you split 3x weekly, should i try doing something like that?

 

[seelos]

Increase the volume. At worst it won't make a difference.. At best it'll significantly lower peak concentration in your blood and spread out absorption. Since sides typically correlate with drug peaks, it should help reduce them.

A rough simulation of the difference in absorption and peak level.

View attachment 333646

(ignore the numbers, they're arbitrary, the curve is what's typical)

While the max 12mg doses are also delivered in .5ml, that dose is slowly titrated up to over time. You have no tolerance to sides built up yet.

If you add 1.2ml the remaining 3 2mg doses will be .5ml each.

Assuming it's not Sema. But if it was 2.5mg of Sema, I think you'd both be in much worse shape than you are even now, and while it's not impossible, it's unlikely that kind of switch would happen with Lobster.

Thank you, I’ll add that 1.2ml. I still think i’m going to hold off on injecting for a week though.
One important factor i forgot to mention that is definitely affecting this - my mom has taken ozempic before, which explains her reaction being a lot less severe than mine. However I still don’t understand why mine was so bad

 

[FuriousAngus]

that’s good insight thank you. did you also start out on the 2mg dose? why do you split 3x weekly, should i try doing something like that?

I started out at 2mg/wk split MWF and worked my way up slowly over several weeks until I hit 4mg/wk split MWF. I started lower to avoid any significant sides and because I'm using this drug on a growth phase to improve BG/insulin sensitivity//inflammation.

Reta has taken my A1C from 5.3 IIRC down to 4.8 all while increasing calories to 3800 and consuming 600+ carbs/day. It's absurd.

 

[Ghoul]

Thank you, I’ll add that 1.2ml. I still think i’m going to hold off on injecting for a week though.
One important factor i forgot to mention that is definitely affecting this - my mom has taken ozempic before, which explains her reaction being a lot less severe than mine. However I still don’t understand why mine was so bad

Previous GLP exposure makes a big difference. GLP "Naive" users always have the strongest response and worse sides.

Yes definitely wait. At least 7 days from the first shot, if not more. You'll have some level of Reta in your system for approx 25 days, so the next dose is always building on the previous one (until you reach the 4th week of the same dose, when levels stabilize).

 

[Eddie.]

I've been using Lobster Reta (purple caps) for several months with no issues. It is possible that you've had an unusually bad reaction; I've had sulfur burps here and there on Reta and also a substantial increase in RHR (more than 10-15BPM) at 4mg, but nothing else really. I'm currently on 4mg/wk (divided into 3 shots).

My older sister has been through similar symptoms to yours on a starting dose of pharma Mounjaro.

Same here, I’m using those purple tops and currently doing 1,8mg every other day. Probably it’s a bad reaction to reta. I wish it had some impact on my appetite lol

 

[FuriousAngus]

Same here, I’m using those purple tops and currently doing 1,8mg every other day. Probably it’s a bad reaction to reta. I wish it had some impact on my appetite lol

Probably a good thing cause you're about to delve into minus body fat at this point. Time to G R O W.

 

[Eddie.]

Probably a good thing cause you're about to delve into minus body fat at this point. Time to G R O W.

Wut?? I’m probably >12% rn brah lmao, you’re way leaner than me despite you’re deep in your bulking phase haha!

Honestly the only reason i keep pushing with diet is because I want to leave more room for growth later, otherwise I’d have quit this charade. I’m preparing lunchboxes with 30-40gr cream of rice for my meals, dude it doesn’t even worth the time spending meal prep to eat just 3-4 tbsp haha. Anyway, i hope at least reta shreds some fat off under the radar.

 

[sterlingschrute]

So you skipped last Friday's dose. Did the side effects completely subside as it got closer to the end of the half life (Thursday)? Did your mom end up experiencing any of the same?

Will you be continuing the reta experiment or did the sides turn you off for the time being? Did you leverage any meds (gas-x, beano, etc.) to aid with the gastric emptying?

 

[seelos]

So you skipped last Friday's dose. Did the side effects completely subside as it got closer to the end of the half life (Thursday)? Did your mom end up experiencing any of the same?

Will you be continuing the reta experiment or did the sides turn you off for the time being? Did you leverage any meds (gas-x, beano, etc.) to aid with the gastric emptying?

i managed to not puke wednesday night (with a lot of difficulty, i had to sleep sitting straight up in a chair cycling ice packs for nausea) and i think that helped me to actually complete a digestion cycle, nausea wasn’t nearly as bad thursday. friday i had my appetite completely back and by that night the nausea was gone.

my mom continued with the 2mg injection on friday and she is still doing perfectly fine, some nausea and diarrhea but she's not concerned at all.

as for me, only meds i used throughout the process was tums and then i got zofran on thursday which was unfortunately the earliest i was able to get it from my sister. i will be continuing with retatrutide this coming friday, i was planning on starting out with a 0.75mg dose this time around. the sides were awful but at the end of the day it was my own fault for not being more cautious with a starting dose, not gonna hold it against the compound

 

[eryximachus]

I injected 2mg reta last week on friday and i've been feeling terrible since, monday night and tuesday night at 2 am exactly I've suddenly started waking up from my sleep uncontrollably vomiting everywhere. Of course aside from that having many other sides such as sulfur burps, regular nausea, diarrhea, absolutely zero appetite (getting 1000 calories or less daily), no energy, etc.

At this point i've already decided that I won't be injecting again this coming friday to let my stomach rest and recover, but could I get some advice on how to get back into it? I was thinking I'd wait a week until next friday and then inject 1mg.

Reta has been awful for me so far but based on how terrible these sides have been I can see its very potent I don't want to just stop it alltogether. Let me know what I should do to allow myself to recover and how to reintroduce it.

How are you doing friend?

I injected reta for the first time this past Monday and I feel like shit too. I've been drinking alkaseltzer throughout the day to deal with the stomach upset. ZERO appetite. Like I'm on meth. But without the energy.

Has it gotten better for you?

 

[Ateam2023]

How are you doing friend?

I injected reta for the first time this past Monday and I feel like shit too. I've been drinking alkaseltzer throughout the day to deal with the stomach upset. ZERO appetite. Like I'm on meth. But without the energy.

Has it gotten better for you?

How much did you inject?

 

[eryximachus]

How much did you inject?

About 2.25mg

 

[BamaCrazy]

About 2.25mg

There seems to be an increase in reports of users experiencing extreme hunger suppression on low doses of Reta. I wonder if something changed with the raws used to manufacture UG Reta. A lot of us have used 8-15mg Reta for months without seeing the level of suppression that is now being reported.

 

[sterlingschrute]

How are you doing friend?

I injected reta for the first time this past Monday and I feel like shit too. I've been drinking alkaseltzer throughout the day to deal with the stomach upset. ZERO appetite. Like I'm on meth. But without the energy.

Has it gotten better for you?

try ginger root extract. Nature's Way on Amazon. It helped with my nausea, bloating, and constipation. Warning that it will clear you out within a few hours (toilet). It basically resets your gastric emptying to natural levels (counteracting Reta's /any GLP's slowing of GE).

 

[Ateam2023]

About 2.25mg

for your first dose? Maybe you could try lowering it , thats the obvious thing to do, besides "ride it out", are you utilizing it for bg , cv support or flat out weight loss?

 

[eryximachus]

for your first dose? Maybe you could try lowering it , thats the obvious thing to do, besides "ride it out", are you utilizing it for bg , cv support or flat out weight loss?

Weight loss, glucose control while on HGH.

 

[eryximachus]

try ginger root extract. Nature's Way on Amazon. It helped with my nausea, bloating, and constipation. Warning that it will clear you out within a few hours (toilet). It basically resets your gastric emptying to natural levels (counteracting Reta's /any GLP's slowing of GE).

The gastric emptying scares me, but I have no problem using laxatives when needed including my favorite Dr. Schultz's Intestinal Formula #1 (which includes ginger I think).

The nausea and heartburn is something else though.

 

[eryximachus]

for your first dose? Maybe you could try lowering it , thats the obvious thing to do, besides "ride it out", are you utilizing it for bg , cv support or flat out weight loss?

If the consensus is it will get better, I think I can ride it out.

 

[sterlingschrute]

If the consensus is it will get better, I think I can ride it out.

+1 on what ATeam said. 2mg is the starting clinical dose but there is nothing wrong with titrating up, starting below that minimum clinical dose point. I personally started with 0.5mg E3days, and that helped my body get to the 25-day mark. Just now at 2mg E3days (4mg weekly dose).

The GLPs are all an "embrace the suck" experience. None of them are fun, all of them have unique side effects and reactions with your body.

I can't say I've ever heard of people having an "overall pleasant" experience with a GLP while in a caloric deficit. Even reta, the new almighty GLP3, still sucks in a deficit. Just about the only "pleasant" experience with a GLP on here has been the people on reta in maintenance/bulk calorie levels.

All gets better with time, you will learn what foods are triggers for your body / cause most severe reaction, what times are best for injection (I do nightly to sleep through the first 8ish hours of dose), and what supplements can ease the burden.

TL;DR -- there is no such thing as fun on a GLP, but it does suck less over time

 

[Ghoul]

+1 on what ATeam said. 2mg is the starting clinical dose but there is nothing wrong with titrating up, starting below that minimum clinical dose point. I personally started with 0.5mg E3days, and that helped my body get to the 25-day mark. Just now at 2mg E3days (4mg weekly dose).

The GLPs are all an "embrace the suck" experience. None of them are fun, all of them have unique side effects and reactions with your body.

I can't say I've ever heard of people having an "overall pleasant" experience with a GLP while in a caloric deficit. Even reta, the new almighty GLP3, still sucks in a deficit. Just about the only "pleasant" experience with a GLP on here has been the people on reta in maintenance/bulk calorie levels.

All gets better with time, you will learn what foods are triggers for your body / cause most severe reaction, what times are best for injection (I do nightly to sleep through the first 8ish hours of dose), and what supplements can ease the burden.

TL;DR -- there is no such thing as fun on a GLP, but it does suck less over time

If they're actually used by the pharma protocol, ie, once a week, titrate up every 4 weeks as tolerable, stop and stay on maintainance dose once goal weight is reached, even brutal Semaglutide fades into the background, you feel nothing, and weight remains stable for as long as you stay on that maintenance dose.

Appetite suppression and sides only return if someone forces themselves to eat beyond their appetite and weight start climbing.