Retarutide + HGH (the effect of glucagon on IGF)

[Maciej]

Hi!

I was previously on tirzepatide, never exceeding a dose of 2.5 mg per week (I'm a really good responder) and lost 16 kg on it. Although I had minor side effects, I didn't like the constipation and, more importantly, the food aversion. After stopping, I gained 8 kg, so I decided to switch to retarutide. I'm currently on 1 mg per week and it's very good. I don't have any food aversion or constipation. It works a bit differently overall, as I crave food, but I fill up much faster, which allows me to control my portion size.

I want to add HGH (2-4 iu) for lipolytic and regenerative purposes, but I came across this study: Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins - PMC

The idea is that glucagon release lowers IGF levels in the blood. Additionally, Reddit users have also reported that while taking HGH and testing its levels, their IGF levels drop after incorporating retarutide. Of course, they were talking about slightly higher doses, such as 4-10 mg per week. I also read on this forum that increased glucagon release with retarutide only occurs at 4 mg per week.

So what's the deal? Can someone explain this to me scientifically and from personal experience? Can I use a small (1-2 mg per week) dose of retarutide and incorporate small doses of HGH (2-4 IU) and enjoy all the benefits, i.e., a great lipolytic combo and higher IGF levels?

Best regards,
Maciej

 

[lilhawk]

GH and Reta are amazing together. I use Reta at 2 mg per week with anywhere from 6-10iu of Serostim per day. Keeps my fasting bg perfectly normal and it is impossible for me to gain any fat on this combo. When dieting you will get shredded much faster and much easier with this combo. It feels like cheating it’s so easy. I’ve never had the need to go over 2mg of Reta per week so I can’t speak to higher doses of it, but I can tell you it is THE combo to use to get shredded and stay that way.

 

[Maciej]

What side effects do you have? Of course, they will be one minor one per 1 mg of reta and 3.3-4 iu of HGH.

 

[Rbvasques]

You would likely want to have high IGF1 during a muscle gaining phase, since you are looking to lose weight, you will be in a calorie deficit, which will already likely cause you to have low igf1 levels and not enough nutrients for muscle to grow.
Hgh will help you keep the muscle, and many other benefits, including the short time fat lipolysis effect.
This combo is part of my year round HRT Stack; 200mg test, 1.5mg reta, 4iu hgh.
Life is amazing with that.

 

[Endeavor Fitness]

Honestly, I'm running Reta 1mg /wk, divided into 2 doses, and GH 2 IU's 4 days/wk. I'm not so worried about IGF, because I have built my size. But, TRT + Reta + GH will give your body a good re-comp. I can have more carbs and grow, and still lose fat.

I have to look at the affected population of the studies, also. Most of these studies are on obese diabetics. I'm in the main Reta Reddit sub, a lot of good ppl. But most of them (you won't believe this). They kill their appetite, then ask how we maintain our calories.

 

[Ghoul]

This doesn’t apply to Reta.

Glucagon sensed at liver: Calorie shortage signal.

IGF-1 production and activity is suppressed when there’s a shortage of calories.

Leave more GH free to liberate energy from fat stores (reduce amount of GH converted to IGF-1).

Stop growing (trap IGF-1 in binding protein 1 & 2).

———-

Insulin sensed at liver. Calorie surplus signal.

IGF-1 production and activity is increased when there’s a surplus of calories.

Leave fat stores alone, (increase amount of GH converted to IGF)

Grow more (Free IGF-1 for bioavailability by reducing IGF “trapping” binding hormones 1&2).

———-

In this experiment they injected a “rescue” dose of pure glucagon. 10x+ the level of glucagon equivalent from Reta to suppress IGF-1 bio activity. A strong “calorie shortage” signal.

In Reta, there’s a 1/10th the above strength, weak glucagon “calorie shortage” signal. The liver releases glucose, the main point of glucagon, to raise low blood sugar.

BUT, GLP/GIP massively increase insulin release when blood sugar rises. So glucagon’s little “calorie shortage” signal is immediately neutralized when insulin is released as blood sugar rises (from Reta’s glucagon stimulation of the liver making it generate and release glucose), and as pointed out, that insulin is a “calorie surplus” signal to the liver.

The net effect of this is neutral. IGF-1 and its binding hormones stay in the same balance they were without Reta, and what tips the balance is actual calorie intake. Deficit, IGF-1 down, Surplus, IGF-1 up.

 

[ChemBB]

“rescue”

How do you type these weird left/right "quotes"?

 

[Ghoul]

How do you type these weird left/right "quotes"?

View attachment 360343

It’s automatic. Are you saying it doesn’t happen when you put a word in quotes in the post entry box?

 

[osqe]

How do you type these weird left/right "quotes"?

View attachment 360343

On the iPhone turning on smart punctuation under keyboard settings defaults all quotation marks to those smart quotations. Idk about what it is called in Android, but he is probably just using different settings than you.

 

[orkunalpsoy]

GH ve Reta birlikte inanılmaz etkili. Haftada 2 mg Reta'yı günde 6-10 IU Serostim ile birlikte kullanıyorum. Açlık kan şekerimi mükemmel derecede normal tutuyor ve bu kombinasyonla yağlanmam imkansız. Diyet yaparken bu kombinasyonla çok daha hızlı ve kolay bir şekilde kas kütlesi kazanacaksınız. O kadar kolay ki, sanki hile yapıyormuşsunuz gibi geliyor. Haftada 2 mg'ın üzerinde Reta kullanma ihtiyacı hiç duymadım, bu yüzden daha yüksek dozlar hakkında yorum yapamam, ancak size söyleyebilirim ki, kas kütlesi kazanmak ve öyle kalmak için kullanılması gereken en iyi kombinasyon bu.

Kullandığım jenerik gh hiçbir yan etkiyi kesmedi. Sonra tirzepatinin neden olabileceğini araştırdım. 10 ünite bile vurdugumda ne bir su tutumu nede başka birşey oluyor. Sabah açlık kan şekeri sonrası ilaç vurup bir süre sonra yine kan sekerime bakıyorum ve hiçbir oynama yok. İlaç boş diye düşünüyordum ama sonra bu yorumları gördüm. Bir bilgim varmı? 2 gün önce son tirze dozumu aldım. Geçerli bir kan şekeri testi için kaç gün beklemem lazım sence?

 

[blokje Ham]

Het is belangrijk om te weten dat dit het geval is. Zorg ervoor dat de tirzepatinine geen olabileceğini araştırdım is. 10 Een aantal dingen die u kunt doen, zijn uw kledingstukken niet gebruiken. Het kan zijn dat uw kind zeker van plan is om te bakken en te koken. Het is een goed idee om dit te doen. Wil je weten wat? 2 keer een keer een poging doen. Wat kan het zijn dat u kunt testen of u het zinvol vindt?

Praat gewoon Engels. Of ga naar je Turkse Meso RX Forum.

 

[orkunalpsoy]

GH and Reta are amazing together. I use Reta at 2 mg per week with anywhere from 6-10iu of Serostim per day. Keeps my fasting bg perfectly normal and it is impossible for me to gain any fat on this combo. When dieting you will get shredded much faster and much easier with this combo. It feels like cheating it’s so easy. I’ve never had the need to go over 2mg of Reta per week so I can’t speak to higher doses of it, but I can tell you it is THE combo to use to get shredded and stay that way.

The generic GH I'm using hasn't stopped any of the side effects. Then I researched what might be causing it: tirzepatine. Even when I inject 10 units, I don't experience any water retention or anything else. I inject the medication after a fasting blood sugar test in the morning, and then check my blood sugar again after a while, and there's no change. I thought the medication was useless, but then I saw these comments. Do you have any information? I took my last dose of tirzepatine two days ago. How many days do you think I should wait for a valid blood sugar test?

 

[Hanna9fa]

GH and Reta are amazing together. I use Reta at 2 mg per week with anywhere from 6-10iu of Serostim per day. Keeps my fasting bg perfectly normal and it is impossible for me to gain any fat on this combo. When dieting you will get shredded much faster and much easier with this combo. It feels like cheating it’s so easy. I’ve never had the need to go over 2mg of Reta per week so I can’t speak to higher doses of it, but I can tell you it is THE combo to use to get shredded and stay that way.

Hi!

I was previously on tirzepatide, never exceeding a dose of 2.5 mg per week (I'm a really good responder) and lost 16 kg on it. Although I had minor side effects, I didn't like the constipation and, more importantly, the food aversion. After stopping, I gained 8 kg, so I decided to switch to retarutide. I'm currently on 1 mg per week and it's very good. I don't have any food aversion or constipation. It works a bit differently overall, as I crave food, but I fill up much faster, which allows me to control my portion size.

I want to add HGH (2-4 iu) for lipolytic and regenerative purposes, but I came across this study: Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins - PMC

The idea is that glucagon release lowers IGF levels in the blood. Additionally, Reddit users have also reported that while taking HGH and testing its levels, their IGF levels drop after incorporating retarutide. Of course, they were talking about slightly higher doses, such as 4-10 mg per week. I also read on this forum that increased glucagon release with retarutide only occurs at 4 mg per week.

So what's the deal? Can someone explain this to me scientifically and from personal experience? Can I use a small (1-2 mg per week) dose of retarutide and incorporate small doses of HGH (2-4 IU) and enjoy all the benefits, i.e., a great lipolytic combo and higher IGF levels?

Best regards,
Maciej

I have been on Reta for two weeks 1mg per week and yesterday i went up to 2mg
I currently feel a bit weird specialy after food i feel like i want to puke ! Does it happen to you please?
Thanks !