Retatrutide

[gotgrowth]

Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?

 

[Here2Learn]

Your user name is very familiar...

I dose 750mcg every morning. You're saying if I dosed at night it might make the insomnia less apparent?

Yea, sometimes the timing can make the sides line up better to your day. Even though it was ill logical for me to have benefit from dosing at night, being my issue was normally the next day, it solved my problem.

Might seem familiar as I’ve made a few posts tracking my experience with different peptides. My guess anyway.

 

[dick_starbuck]

Yea, sometimes the timing can make the sides line up better to your day. Even though it was ill logical for me to have benefit from dosing at night, being my issue was normally the next day, it solved my problem.

Might seem familiar as I’ve made a few posts tracking my experience with different peptides. My guess anyway.

I seem to remember someone from forums years ago with that user name. Maybe it was here2study... primordial performance rep maybe? Back in the wild west days of prohormones.

Maybe I'll try a different dosing time. Thanks.

 

[Here2Learn]

I seem to remember someone from forums years ago with that user name. Maybe it was here2study... primordial performance rep maybe? Back in the wild west days of prohormones.

Maybe I'll try a different dosing time. Thanks.

Nope not me, haven’t been around that long in this world. I wish I had been, would have saved me years of crappy living with crap health.

 

[Delux]

Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?

I would buy a few kits of both the 10mg and 20mg

10mg for when you start the vials can stay a little fresher, they will degrade over 8-10 weeks once reconstituted.

Then if/when your dose is in the 6-10 MG range you can use the 20mg kits.

 

[SubparMarioBro]

Figured I’d share this. I do not have a high baseline level of physical strength like most of you. I work with my hands for a living but I’m in one of the lazier trades so that’s not saying much. I spent my 30s letting my body go to shit.

That said, if your starting point is trash you can in fact put some muscle on while losing a ton of weight on reta. A little TRT and some weightlifting really helps.

 

[Anat]

View attachment 323261

Figured I’d share this. I do not have a high baseline level of physical strength like most of you. I work with my hands for a living but I’m in one of the lazier trades so that’s not saying much. I spent my 30s letting my body go to shit.

That said, if your starting point is trash you can in fact put some muscle on while losing a ton of weight on reta. A little TRT and some weightlifting really helps.

Man, seriously impressive work - dropping from 46% to 25% is no joke. Keep pushing, you’re closing in on that 15%! I can’t imagine how tough the grind must’ve been, but you’ve proven it’s possible. Just stay consistent - the hardest part is already behind you.

 

[SubparMarioBro]

Man, seriously impressive work - dropping from 46% to 25% is no joke. Keep pushing, you’re closing in on that 15%! I can’t imagine how tough the grind must’ve been, but you’ve proven it’s possible. Just stay consistent - the hardest part is already behind you.

It’s honestly been pretty easy.

 

[sliderke]

For those that tried retatrutide, at what dose did you start to notice a decrease in appetite?

I started with 0.5 mg week 1, then 1 mg week 2, then 1.5 mg week 3. So far, I haven't noticed anything. So, I'm wondering if my dose is too low or if maybe my retatrutide is fake (I purchased from skye peptides, if anyone has experience with them).

I only have experience with tirzepatide. And even at the lowest 2,5 mg I already lost appetite a lot. Haven’t tried retra yet since I don’t find a good source in Europe.

 

[Ghoul]

I think a significant amount of GLP induced sleep disruption is from low glucose overnight.

I discovered by accident, a small amount of carbs within an hour of sleep stabilizes levels and restores more normal sleep patterns.

 

[Bobik]

I think a significant amount of GLP induced sleep disruption is from low glucose overnight.

I discovered by accident, a small amount of carbs within an hour of sleep stabilizes levels and restores more normal sleep patterns.

It doesn't work for me. I always take carbohydrates before bed and I don't sleep well on Reta.

 

[Sampei]

It doesn't work for me. I always take carbohydrates before bed and I don't sleep well on Reta.

Because that's not the reason

 

[Sampei]

I think a significant amount of GLP induced sleep disruption is from low glucose overnight.

I discovered by accident, a small amount of carbs within an hour of sleep stabilizes levels and restores more normal sleep patterns.

It's not. Wore a CGM for 15 days and I had not once low glucose at night and my sleep has been disrupted the same

 

[Nidus]

It's not. Wore a CGM for 15 days and I had not once low glucose at night and my sleep has been disrupted the same

When you really run low glucose you usually get an extremely dry mouth, cold sweats, jittery, have a solid migraine and the thirst and hunger will be crazy.
Also your fasting glucose after the night might be really high. Symptoms vary but is usually a combination of at least 2-3

But to really experience that i believe you need a blood sugar below 60-50 or so

 

[Ghoul]

It's not. Wore a CGM for 15 days and I had not once low glucose at night and my sleep has been disrupted the same

I'm not sure what the mechanism of action is then. It's not likely tryptophan release, which only helps you fall asleep faster.

There are numerous theories behind the observation that high GI, solid food, an hour before bed can improve sleep quality. One is that insulin release triggers the expression of gene that regulates circadian rhythm, for instance. Perhaps GLPs improved insulin sensitivity reduces insulin release, interfering with the function of that gene, and disrupts the circadian rhythm.

Whatever it is. like I said, after breaking the "don't eat late" rule I inadvertently found I had a great night's sleep and have been able to replicate it. The only problem I get GERD symptoms from eating too late, unfortunately.

Anyway, may be worth a try of some carbs a hour before sleep for someone else, despite being counterintuitive.

Some interesting findings regarding late night eating and potentially improved sleep quality in the conclusion section of this study.

Sleep in Elite Athletes and Nutritional Interventions to Enhance Sleep - PMC

Sleep has numerous important physiological and cognitive functions that may be particularly important to elite athletes. Recent evidence, as well as anecdotal information, suggests that athletes may experience a reduced quality and/or quantity of ...

pmc.ncbi.nlm.nih.gov

 

[dinfar1337]

It makes sense if you think every drug is like Testosterone. When all you've got is a hammer(head), everything looks like a nail.

Immunogenicity is the propensity of a protein based drug, like a peptide, to induce an unwanted anti-drug neutralizing effect, making it less effective. It's an enormous area of concern to the FDA and every single pharma peptide development process focuses on it. After demonstrating a certain drug, at a certain dose, using a certain frequency of administration, in a particular container, doesn't cause too much immunogenicity, if anything is changed, they have to prove it all over again. Once a week is the frequency that's been proven with all the GLP drugs to keep immunogenicity to a manageable level.

You can become somewhat, or even completely immune to the drug. You can become immune to the hormone it's mimicking. It may be short term, or permanent, like any other vaccine, because it's the same process going on.

So while you believe the hundreds of millions spent every year to ensure immunogenicity doesn't result in damage to health is meaningless BS, and your "bro science" method must be better, go for it.

These drugs are effective in 99% of cases for rapid, long term, weight loss, following the pharma protocols tested on thousands of subjects., yet somehow that's not good enough for you. You need a special, custom protocol dictated by your "feels". Do what the fuck you like, I'll enjoy reading about clowns like you who develop crazy metabolic disorders down the line because you stimulated your immune system into attacking your natural hormones, but try not to spread the disease of harmful practices, especially as it's for no benefit since the proven safe protocol works just fine. MESO is about HARM REDUCTION.


"Typically, repeated administration is more immunogenic than a single dose, and immunogenicity increases with more frequent dosing and longer-term treatment."

https://www.fda.gov/media/85017/download

this is interesting, i just watched vigorous steves deep dive on reta and im planning to jump on glps for the first time. he recommend dose of 1mg monday wed friday 3mg weekly total for a bodybuilding context. now ill probably go with weekly injections instead ty for info.

 

[Ateam2023]

this is interesting, i just watched vigorous steves deep dive on reta and im planning to jump on glps for the first time. he recommend dose of 1mg monday wed friday 3mg weekly total for a bodybuilding context. now ill probably go with weekly injections instead ty for info.

i'm also curious about reta, i just don't have a problem not eating, i just dont want my appetite suppressed at all , i like ALL the other positive things about it though,, so i guess a lower dose may work in that instance?

 

[Ghoul]

this is interesting, i just watched vigorous steves deep dive on reta and im planning to jump on glps for the first time. he recommend dose of 1mg monday wed friday 3mg weekly total for a bodybuilding context. now ill probably go with weekly injections instead ty for info.

Contaminants (of the protein aggregate type AND inorganic particulates like glass and rubber) contribute to immunogenicity risk along with "exposure events" as the two primary factors (other than individual sensitivity) that can cause this problem.

However, I think there's more risk reduction from filtering than reducing injection frequency. Ideally you do both, but the GLP peptide monomers have very low immunogenic potential in their pure, unaggregated form, because they resemble human hormones so closely the immune system ignores them.

It's only once they aggregate into millions of random "mutant" forms that they're seen as invaders triggering an immune response. And we know the presence of trash like glass and rubber only amplifies the alarm that attracts immune cells (the "adjuvant" effect").

 

[Sampei]

i'm also curious about reta, i just don't have a problem not eating, i just dont want my appetite suppressed at all , i like ALL the other positive things about it though,, so i guess a lower dose may work in that instance?

Reta even at high dosage doesn't blunt appetite much, at least for me at 6mg I could eat a cow. From 8 to 10mg I started not being able to binge eat anymore, not that I did eat that way but well if I wanted I could before now not happening

 

[dinfar1337]

i'm also curious about reta, i just don't have a problem not eating, i just dont want my appetite suppressed at all , i like ALL the other positive things about it though,, so i guess a lower dose may work in that instance?

yeah? me neither but its fucking hard cutting im down to 2100 calories pushing down below 10% is fucking disastrous man. i am surviving it without glps but i really want it for next cut to make it easier

 

[dinfar1337]

Reta even at high dosage doesn't blunt appetite much, at least for me at 6mg I could eat a cow. From 8 to 10mg I started not being able to binge eat anymore, not that I did eat that way but well if I wanted I could before now not happening

does sema/tirz suppress appetite better?