Should I try a GLP1 agonist?

[Luke391]

I struggled with weight all my life and have lost weight and regained it multiple times.
I know everything I need to know to loose weight succesfully amd stay like that but Ijist can't because as soon as I try to get a little leaner I get extreme hunger and feel constantly exhausted even in a mild calorie deficit (like 300-500calories x day).

First time Iost weight I kept it off for like a year before burning out and regaining it, the whole time I felt terrible.

Second time lost weight in like 3 months, kept it off for another 3 and regained all of it plus some more.

Third time around I lost weight in 6months or so, kept it off for 1.5years and then regained it all. Again during these 1.5years I was hungry and tierd all day every day.

For the past 6months I have been trying to loose weight but keep loosing and regaining the same 10lbs because I cannot stick to a decent diet. My issue is food portions. I know how to eat and excercise but my body just doesn't seem to accept being lean. Once I get around 20% bodyfat or so my hunger goes out of control and even my energy crashes.

My sleep has always been fine and I have no nutrient deficiencies.

So long story short, do I try a GLP1? If so which one should I try?

Also the leanest I ever got to was like 13-14%, bodyfat , so it's not like I'm being unresonable with my goals, now I'm like 25-26% and struggling to loose.

Another issue is that to loose weight in the past I had to engage in extreme volume eating and now have stretched out my stomach capacity significantly. what can I do to help reduce my stomach capacity?

 

[nullandvoid]

I would say yes. Perfect use case. I would say Tirzepatide, but that is just my personal experience. Some prefer Semaglutide... and others like the newer ones. I had brutal constipation on Sema, and its appetite suppression pretty much vanished over time... leaving me unable to shit with no benefit. Tirzepatide caused some constipation, but it's mostly gone, now. Zero side effects otherwise, and once I finally bumped up to 5mg a week, food noise reduced to near zero. It is easy (and quite wonderful) on this side, viewing food as just fuel. On the other side is an endless cycle of dopamine addiction and feeling like a failure every morning for the previous night's indiscretions. We've got some real GLP aficionados on here that can really help you out. I'm just a layman with personal anecdotes.

 

[Luke391]

I would say yes. Perfect use case. I would say Tirzepatide, but that is just my personal experience. Some prefer Semaglutide... and others like the newer ones. I had brutal constipation on Sema, and its appetite suppression pretty much vanished over time... leaving me unable to shit with no benefit. Tirzepatide caused some constipation, but it's mostly gone, now. Zero side effects otherwise, and once I finally bumped up to 5mg a week, food noise reduced to near zero. It is easy (and quite wonderful) on this side, viewing food as just fuel. On the other side is an endless cycle of dopamine addiction and feeling like a failure every morning for the previous night's indiscretions. We've got some real GLP aficionados on here that can really help you out. I'm just a layman with personal anecdotes.

thank you for the reply. I'll keep asking around on here.

 

[nullandvoid]

This thread is a really good starting point, but there are tons of information all over:

D

Thread 'Giant Semaglutide Thread (and other GLP-1 / GIP agonists)'

Jul 26, 2022

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

• Doodle
• Replies: 3,842
• Forum: Weight Loss Drugs

• 

 

[Ghoul]

What you're describing is a typical experience. More than just being a near "miracle drug" in terms of weight loss, along with a long and growing list of health benefits that are independent of weight, this class of medications has provided concrete evidence of what's been long hypothesized. Weight is largely determined by a system designed to maintain homeostasis, and the tools your biology has to keep you in a narrow weight range, are physically and psychologically potent.

GLPs alter the "setting" in this system.

There's no need to feel shame, unless
you fail to take action now that there's a solution.

I have significant experience with GLPs, not only personally but with many others, long before "Ozempic" became well known.

I urge you to keep things straightforward, stick as closely as possible to the proven successful pharma protocol, for the best chance of safe, long lasting, permanent really, weight loss. There's a lot of quackery out there, and it's best avoided.

The first decision is simple. Semaglutide or Tirzapatide, Both are effective and almost certain to get you to your goal weight. Sema is cheaper, $50 will cover your first year. Tirz is closer to $250, but the side effects are less intense, and the GIP component offers additional health benefits.

 

[Luke391]

What you're describing is a typical experience. More than just being a near "miracle drug" in terms of weight loss, along with a long and growing list of health benefits that are independent of weight, this class of medications has provided concrete evidence of what's been long hypothesized. Weight is largely determined by a system designed to maintain homeostasis, and the tools your biology has to keep you in a narrow weight range, are physically and psychologically potent.

GLPs alter the "setting" in this system.

There's no need to feel shame, unless
you fail to take action now that there's a solution.

I have significant experience with GLPs, not only personally but with many others, long before "Ozempic" became well known.

I urge you to keep things straightforward, stick as closely as possible to the proven successful pharma protocol, for the best chance of safe, long lasting, permanent really, weight loss. There's a lot of quackery out there, and it's best avoided.

The first decision is simple. Semaglutide or Tirzapatide, Both are effective and almost certain to get you to your goal weight. Sema is cheaper, $50 will cover your first year. Tirz is closer to $250, but the side effects are less intense, and the GIP component offers additional health benefits.

thank you for the comprehensive response.
If I were to try sema, would you recomment just staring with the usual .25mg per week or further splittimg the dosage to have more consistant amounts of the drug in my sistem (like .125mg 2xweek or even .08mg 3xweek).

Also I struggle with quite severe BED, but I think that it is the result of me trying to get to a bodyfat below what is comfortable for my body, as when I was a kid I was fat but always ate normally, I only started binge eating after my first weight loss attemp. I lost weight and stayed kinda lean for a year, then I burned out and started binge eatin and it got worse from there. Also it's never emotional, it's just that I want to eat way more than it would be appropriate to eat. the leaner I am the worse this tendency becomes. When I was 15%bf or so I was watching mukbang videos all day long as a way to feel like I was eating.

 

[PaintDrinker]

Tirzepatide for me is now a staple. 5mgs a week when I’m growing for the many health benefits, 15mgs during a cut to keep hunger at bay. Sometimes I’ll go up to 20 if needed, I only use generics.

 

[Ghoul]

thank you for the comprehensive response.
If I were to try sema, would you recomment just staring with the usual .25mg per week or further splittimg the dosage to have more consistant amounts of the drug in my sistem (like .125mg 2xweek or even .08mg 3xweek)

Don't stray from the pharma protocol needlessly. Don't split the dose, There are risks those who advocate that approach are completely unaware of, and are using these protein therapeutics as if they were "regular" drugs, which they're not.

The TLDR is that you can risk developing a type of immunity that reduces, or even eliminates the effectiveness not only of the GLP being used, but others in the same class. Potentially for years. Possibly even permanently.

The only safe area to deviate is in how quickly you titrate the dose, since you have greater control than someone with a box of fixed dose pens,

Typically, men require a larger dose vs women, but the sides from Sema can be intense, initially, so start with once a week, .25mg. If you feel nothing whatsoever in the first week, you can titrate to .50mg. Keep in mind levels build over 4 weekly doses, so you don't truly know the maximum effect of a given dose until at least well into the second week.

Try to get smaller vials so they spend less time in reconstituted form. Ensure you reconstitute to a volume that makes your expected dose .5ml. Use pharma grade BAC water (Hospira/Pfizer).

Again, I urge you, adhere to the pharma protocol, and you'll almost certainly reach goal weight and maintain it.

The end goal you'll reach is a maintainance dose where you'll feel nothing whatsoever, which will keep you at an ideal weight, and reap a whole host of protective health benefits for a lifetime.

 

[Luke391]

Don't stray from the pharma protocol needlessly. Don't split the dose, There are risks those who advocate that approach are completely unaware of, and are using these proteins therapeutics as if they were "regular" drugs, which they're not.

The TLDR is that you can risk developing a type of immunity that reduces, or even eliminates the effectiveness not only of the GLP being used, but others in the same class. Potentially for years. Possibly even permanently.

The only safe area to deviate is in how quickly you titrate the dose, since you have greater control than someone with a box of fixed dose pens,

Typically, men require a larger dose vs women, but the sides from Sema can be intense, initially, so start with once a week, .25mg. If you feel nothing whatsoever in the first week, you can titrate to .50mg. Keep in mind levels build over 4 weekly doses, so you don't truly know the maximum effect of a given dose until at least well into the second week.

Try to get smaller vials so they spend less time in reconstituted form. Ensure you reconstitute to a volume that makes your expected dose .5ml. Use pharma grade BAC water (Hospira/Pfizer).

Again, I urge you, adhere to the pharma protocol, and you'll almost certainly reach goal weight and maintain it.

The end goal you'll reach is a maintainance dose where you'll feel nothing whatsoever, which will keep you at an ideal weight, and reap a whole host of protective health benefits for a lifetime.

ok , thank you very much, I'll stick to the regular protocol. how long is it ok for a vial to stay in liquid form in the fridge?

 

[rexy]

Also I struggle with quite severe BED, but I think that it is the result of me trying to get to a bodyfat below what is comfortable for my body, as when I was a kid I was fat but always ate normally, I only started binge eating after my first weight loss attemp. I lost weight and stayed kinda lean for a year, then I burned out and started binge eatin and it got worse from there. Also it's never emotional, it's just that I want to eat way more than it would be appropriate to eat. the leaner I am the worse this tendency becomes. When I was 15%bf or so I was watching mukbang videos all day long as a way to feel like I was eating.

This is the reason I decided to try a GLP1. and in particular Sema because it binds to the receptor stronger than the others - and the anti-addiction/compulsion properties of these compounds seem a result of the GLP action.

I've only been on it 3 days but I have noticed becoming more indifferent to food already. I don't care if it's placebo or not (because I was hunting around for experiences and found many positive ones so I'm kind of expecting it), but I've avoided my usual overeating issue for the 3 days so far. I'm also more indifferent in that I can seemingly turn off the 'on' switch easier, and just stop myself. And that is not usually me.

Half my adult life (actually, most of it) has been slavery to a mild form of BED that went on for 6-8 months of the year at a time before i'd randomly suddenly snap out of it. Then I'd have a few months of peace and the cycle would renew. So I guess it wasn't that mild, at least not on my psyche. I'm hoping this can help change that permanently.

 

[Ghoul]

ok , thank you very much, I'll stick to the regular protocol. how long is it ok for a vial to stay in liquid form in the fridge?

Since you're using something from an underground lab, that's one of the many unknowns we have to deal with.

What we do know is pharma BAC will keep it in better condition, longer.

The more dilute it is, while keeping the volume of the injection to .5ml per dose (ideally, more is acceptable), the less degradation it'll suffer.

The less time in reconstituted form the better.

A kit of 5mg vials will cover your first 6 months+. I wouldn't go any larger than that. If you reach 2.4mg/wk, 10mg vials would be reasonable for the next kit.