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So you use recipe with displacement calcs?

To achieve even close to similar accuracy with displacement method as vol flask method means all your inputs have to be highly accurate and those densities themselves are accurately measured using a volumetric flask.

In the end you have to have a very accurate way to measure volume one way or another since your API concentration is mg/ml. It is either baked in up front on your displacement values or measured on the back end for total solution volume.

With volumetric flask method you have two error sources...

(1) mass of API
(2) volume of batch

Any other method would have more than two error sources. That's important when considering propagation of error.

The volumetric flask method meant to simplify his life, not complicate it. Hence the additional $$$. Would be asinine to spend more money for less accurate/precise equipment/process.

Most accurate and precise method by far. It is how standardized reference solutions are made for molarity with extremely high accuracy (e.g., less that 0.1% error at 1 L volume).
The variance you get from a labtest at Jano is more than the % of error you can get from simply using a scale and converting ml to gr.

The bigger the batch the less is the error even if you pour slightly less or more.

A friend just did test P 10mg/ml And came out dosed with a 2% variance from the target on a small batch of something like 50ml, using a scale as the only instrument for measurement.

Is volumetric flask more accurate? Sure, is it needed or even worth it? In my opinion is not. Plus it's a lot more work for maybe a 1% more accuracy, same accuracy that get squashed by the variance of Jano labtest.

I mean considering most of the brewers use beakers with a 5% (if lucky) tolerance of error and some of them can still get it close to target I would say an analytical scale is already quite an improvement.

There is a limit between what can be done and what is worth to be done.

Considering the variance allowed in the official pharmacopeia one would be better off trying to use the method that involve the least work and time while still maintaining a reasonable level of accuracy.

Just the procedure for cleaning those volumetric flask is a lot of time wasted that could be used in a much more productive way.
 
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Considering the variance allowed in the official pharmacopeia one would be better off trying to use the method that involve the least work and time while still maintaining a reasonable level of accuracy.

Just the procedure for cleaning those volumetric flask is a lot of time wasted that could be used in a much more productive way.
Agreed..

What is much more reasonable for regular Brewers? Lol

Graduated cylinder = g2g
 
Agreed..

What is much more reasonable for regular Brewers? Lol

Graduated cylinder = g2g
I still feel the scale is a superior improvement for really not much work at all, takes 2 minutes to multiply the values of the ingredients and then pour it in the beaker while watching a scale display, using a simple smaller beaker as the pouring vessel allow one to pour exactly what is needed with an error of 0.XX that in real life translate to zero.
 
Is volumetric flask more accurate? Sure, is it needed or even worth it? In my opinion is not. Plus it's a lot more work for maybe a 1% more accuracy, same accuracy that get squashed by the variance of Jano labtest.
I respect your opinion. I have yet to see what Jano's true HPLC method precision is. Gonna depend on the analyst as well. I posted above his instrument precision much less that 1% based on what he shared.

There is what is in the vial and what Jano measures in the vial. Good point.

Clearly if a vendor is getting intra-batch vial to vial variance 2% or less then most will be happy. Either method above definitely better than whatever the hell some of these vendors are doing. I agree with you there.

McLaren vs decent sedan if accuracy is what matters. That was my point.
 
I still feel the scale is a superior improvement for really not much work at all, takes 2 minutes to multiply the values of the ingredients and then pour it in the beaker while watching a scale display, using a simple smaller beaker as the pouring vessel allow one to pour exactly what is needed with an error of 0.XX that in real life translate to zero.
dont people do this by default? feel like its so common in hand with meal prepping.
 
dont people do this by default? feel like its so common in hand with meal prepping.
No they don't.
Most brewers use graduated cylinders and it's not bad but I find it annoying and so much shit to clean all the time. Plus those graduated cylinders can have some hefty error sometime and you need multiple size of them too.

Some just use graduated beakers xD and you can tell

Since I started using the scale method I never looked back.
 
No they don't.
Most brewers use graduated cylinders and it's not bad but I find it annoying and so much shit to clean all the time. Plus those graduated cylinders can have some hefty error sometime and you need multiple size of them too.

Some just use graduated beakers xD and you can tell

Since I started using the scale method I never looked back.
Do u mind linking ur scale to me
 
Since I started using the scale method I never looked back.
Once you dial in your displacement values on multiple iterations I will accept it, xD. They will only be as good as Jano's error though, haha.

Also density of oil from one batch to another will move. See spec sheet on MCT for example.

Yes i realize no one gives a shit. But then they want accurately dosed products.
 
Female products aside, i don't believe it to be true.
Most here would rather slightly overdosed products, not precisely dosed products and most importantly, not under-dosed products.
Yep, you are right. Forget about that. 223 mg/ml "better" than 200 mg/ml for TC200. Smh.
 
0.1g precision isn’t good enough. 0.001g is only accurate to 0.01g for example. And any scale doesn’t work. Mine was expensive but I want to compare it to what he has. It seems we spent very close to the same

xiaomi scale 0.1g precision under 1000g. what is 0.1g compared to brewing 400gtest? even less than its 0.0x%

and its rather cheap
 
220? no
205-210.

Pharma variance is 10% after all.

That test was 250 btw.
The vendor got hell for it.

If it was 260? it'll be praised to heavens.
Well let's see what happens if a vendor starts delivering 1-2% variance consistently.

Maybe we can get Jano to do 10 preps of TC200 sample and he can share his HPLC method precision as well. Would be instructive.
 
I mean yeah what is 0.1g not much when ur brewing a kilo or more at a time but still

I’m not trusting a $20 Chinese scale. More than happy to spend money on something good, I already have, way before even thinking of starting this actually just curious on what he uses.

And I mean obviously I already have scales. Nothing $20 from china would help me in any way. Only would help if I didn’t have a scale at all and was brewing a kilo at a time straight out of vendor packaging lmao
 
I’m not trusting a $20 Chinese scale. More than happy to spend money on something good, I already have, way before even thinking of starting this actually just curious on what he uses.
no worries, i actually trust the brand xiaomi, i both have their watch which is better than apple watch and their scales all over my home. leading tech giant in china. its a good brand.

you should probably look for something more expensive as you'll be expanding ugl even if he sends something with similar specs to mine you probably need upto 10kg or more to plan for the future. have a good day.
 
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