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Professor Kristian Gundersen comments on results of new steroid study published in the Journal of Physiology. The study results suggests the use of anabolic steroids could have life-long positive benefits:
Source: Further proof that life bans for steroid abusers would be justified | Herald Scotland
This has prompted Gundersen, who says doping bans in sport are "a political question", to consider ethical ways of doing human research on steroids.
"It is hard to translate from a mouse which only lives two years, but the biology suggests to me that it could be very long-lasting in a human. To me, that makes a four-year suspension rather a short time.
"The results in our mice may correspond to the effects of steroids lasting for decades in humans, given the same cellular 'muscle memory' mechanism . . . Three months after withdrawal of the drug [approximately 15% of a mouse's life span] their muscles grew by 30% over six days following load exercise. The untreated mice grew insignificantly. It is rare in my experience to get such clearcut results."
He explained that many basic biological mechanisms are similar in all mammals, which is why a lot of medical research is done in mice. "A mouse lives only two years, so you can't compare with humans in absolute terms, but the mechanism relating to the cell nuclei are such that you would expect it to be very long-lasting in humans.
"When you give steroids, muscle grows and you get more power. You also get an increase in the number of cell nuclei surrounded by machinery for synthesising the protein that builds the muscle. Previously it was believed when you de-trained, or removed the drug, the muscle shrunk and you lost these extra nuclei. But we have shown they never disappear. They are not eliminated.
"For me the greatest interest is not in sport doping, but in helping the elderly. These nuclei are very stable in humans. They last several decades. To increase the nuclei is much harder when you are old than when you are young. So it is good advice to do some exercise when you are young. Even if you don't train throughout life, you might benefit from that in old age. Frailty of the elderly is big problem. There are implications there."
Source: Further proof that life bans for steroid abusers would be justified | Herald Scotland
