Sudden reaction to Tesamorelin

[Okkang317]

I am currently on my third cycle of Tesamorelin.. I’m doing 2mg at night combined with 200mcg of IPA at night. 5 days on/ 2 days off.
When I have a late meal I either skip that night or do it in the morning fasted.

On my previous two cycles I never had a bad reaction but few days ago after injection my whole body started itching and I broke out with hives all over my body. I think it was an allergic reaction. I took a Benadryl and it went away but after that incident I took a few days break and now every time I inject tesa I get itchy..
Just wondering if anyone has experienced this before??

 

[Nidus]

I am currently on my third cycle of Tesamorelin.. I’m doing 2mg at night combined with 200mcg of IPA at night. 5 days on/ 2 days off.
When I have a late meal I either skip that night or do it in the morning fasted.

On my previous two cycles I never had a bad reaction but few days ago after injection my whole body started itching and I broke out with hives all over my body. I think it was an allergic reaction. I took a Benadryl and it went away but after that incident I took a few days break and now every time I inject tesa I get itchy..
Just wondering if anyone has experienced this before??

Sounds like an allergic reaction, might be contaminated or contains something you body doesnt like. Same brand? Doing anything differently?

 

[Ateam2023]

I am currently on my third cycle of Tesamorelin.. I’m doing 2mg at night combined with 200mcg of IPA at night. 5 days on/ 2 days off.
When I have a late meal I either skip that night or do it in the morning fasted.

On my previous two cycles I never had a bad reaction but few days ago after injection my whole body started itching and I broke out with hives all over my body. I think it was an allergic reaction. I took a Benadryl and it went away but after that incident I took a few days break and now every time I inject tesa I get itchy..
Just wondering if anyone has experienced this before??

Filter it,,

 

[Ghoul]

Filter it,,

Immunogenic reaction. Common with Tesa.

Filter it.

I found when filtering into a vial, the first dose would be fine, and the next 4 would induce increasing sides. It aggregates quickly, and the aggregates induce or worsen the immune reaction.

I ended up switching to per dose filtration, and the site reaction (itching) is now rare to non-existent.

Also, ensure you're diluting a 10mg vial with 3ml so doses are .6ml.

 

[Middus]

I am currently on my third cycle of Tesamorelin.. I’m doing 2mg at night combined with 200mcg of IPA at night. 5 days on/ 2 days off.
When I have a late meal I either skip that night or do it in the morning fasted.

On my previous two cycles I never had a bad reaction but few days ago after injection my whole body started itching and I broke out with hives all over my body. I think it was an allergic reaction. I took a Benadryl and it went away but after that incident I took a few days break and now every time I inject tesa I get itchy..
Just wondering if anyone has experienced this before??

If you're combining the Tesa with Ipa before injecting, stop doing it and inject them separately.

 

[Ghoul]

If you're combining the Tesa with Ipa before injecting, stop doing it and inject them separately.

Good point I missed that. Definately don't mix them in the same syringe or even inject in the same spot.

 

[Okkang317]

Immunogenic reaction. Common with Tesa.

Filter it.

I found when filtering into a vial, the first dose would be fine, and the next 4 would induce increasing sides. It aggregates quickly, and the aggregates induce or worsen the immune reaction.

I ended up switching to per dose filtration, and the site reaction (itching) is now rare to non-existent.

Also, ensure you're diluting a 10mg vial with 3ml so doses are .6ml.

Thank you

 

[Okkang317]

Sounds like an allergic reaction, might be contaminated or contains something you body doesnt like. Same brand? Doing anything differently?

No but I do combine ipa and tesa into same syringe and inject together.. I thought contamination so I discarded the vial and reconstituted a new vial from a different batch with new bac water, but still getting mild reaction

 

[Ghoul]

No but I do combine ipa and tesa into same syringe and inject together.. I thought contamination so I discarded the vial and reconstituted a new vial from a different batch with new bac water, but still getting mild reaction

Don't mix peptides ever.

Tesa is already probably the most aggregation prone pharma peptide out there. That's why it (Egrifta) was always only available as a single dose vial that you injected right after reconstitution.

It took Thera Tech many years to develop a multi-dose vial formulation that didn't severely aggregate within hours.

A seven dose vial formula was just approved weeks ago, after the FDA demanded more proof aggregates were under control.

Considering UGL has been selling multi-dose vials without giving a shit about this just goes to show the difference in safety and concern for health in pharma that's absent in our peptides.

https://www.theratech.com/news-releases/news-release-details/theratechnologies-receives-fda-approval-egrifta-wrtm-tesamorelin

 

[Okkang317]

Don't mix peptides ever.

Tesa is already probably the most aggregation prone pharma peptide out there. That's why it (Egrifta) was always only available as a single dose vial that you injected right after reconstitution.

It took Thera Tech many years to develop a multi-dose vial formulation that didn't severely aggregate within hours.

A seven dose vial formula was just approved weeks ago, after the FDA demanded more proof aggregates were under control.

Considering UGL has been selling multi-dose vials without giving a shit about this just goes to show the difference in safety and concern for health in pharma that's absent in our peptides.

https://www.theratech.com/news-releases/news-release-details/theratechnologies-receives-fda-approval-egrifta-wrtm-tesamorelin

Thank you so much!
I read your posts regarding filtering peptides and purchased a few loose filters from violet to test and learn how to use it. Haven’t even thought it was possible to filter peptides and definitely think it should be done considering safety measures.
I’ll report back with questions hehe

 

[Ghoul]

Thank you so much!
I read your posts regarding filtering peptides and purchased a few loose filters from violet to test and learn how to use it. Haven’t even thought it was possible to filter peptides and definitely think it should be done considering safety measures.
I’ll report back with questions hehe

Feel free LMK if you have any questions. It was specifically Tesamorelin that got me filtering peptides.

 

[Bozeman]

I mix my tesa /ipa. I get a mild itch then it's gone. I dose 1mg tesa to 500mcg ipa. Same cartridge in a pen. I didn't filter but have filters. Itch last maybe 3-5 min but I'm busy and dont worry about it. Definitely more itchy together than apart.

 

[RandGuy]

Immune reaction is person-specific, with risk increasing over time. When trying CJC-1295 w/ DAC (unfiltered, once weekly), for example, I had no immune reaction over the course of a year, w/ consistently raised IGF-1, but spouse had reaction mid-year, and then lost effect on IGF-1. Similar to what was found by early researchers when studying immune reactions to pharmaceutical rhGH, as I recall, taking up to a year to get a reaction in some cases.

 

[narta]

Immunogenic reaction. Common with Tesa.

Filter it.

I found when filtering into a vial, the first dose would be fine, and the next 4 would induce increasing sides. It aggregates quickly, and the aggregates induce or worsen the immune reaction.

I ended up switching to per dose filtration, and the site reaction (itching) is now rare to non-existent.

Also, ensure you're diluting a 10mg vial with 3ml so doses are .6ml.

 

[songsofpyramids]

I wouldn’t be shocked if you developed an allergy to ipa. Its immunogenicity and ability to cause allergic reaction is why the fda pulled it.

 

[Seppuku]

Yes, i had it very bad after about a week of daily ipamorelin / mod grf usage. My feet would swell, toes go red, and they'd itch like hell, bad enough i had to stop. I looked it up at the time and it's a fairly common reaction.

 

[Type-IIx]

You don’t have to filter the peptides (lol), it’s a known reaction to bacteriostatic water, not tesamorelin — and largely why it is regulated — people overestimate its antimicrobial effects and underestimate its side effects. Try reconstituting with normal saline.

 

[Seppuku]

Yes, i had it very bad after about a week of daily ipamorelin / mod grf usage. My feet would swell, toes go red, and they'd itch like hell, bad enough i had to stop. I looked it up at the time and it's a fairly common reaction.

View: https://www.reddit.com/r/FoodAllergies/comments/1ch11gb/need_urgent_opinion_anaphylaxis/



View: https://www.reddit.com/r/Peptides/comments/18lb5gs/allergic_reaction_to_cj1295_ipamorelin/



View: https://www.reddit.com/r/CJC1295/comments/12j6jwp/cjc_1295_ipamorelin_itching_and_swelling_at/


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[geodesic7]

If you are using the same BAC vial that was first opened with earlier Tesa cycles, the BAC itself could be contaminated after all that time.

 

[songsofpyramids]

I’ve used some old ass Hospira without issues. I know I’m not the only one around here to fo it too. Although possible I think other options like allergy are more probable.