Synthesizing chemicals from scratch

[substratums]

I've seen these videos from Chinese biotech sellers showing how they make their generic HGH.

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Where would you start in learning how to do this? What equipment would be required for someone to do it at a much smaller scale, straight from their home without a facility (if that's even possible)?

 

[TRT]

LC-UV is literally the most used technique in the industry by far and for a good reason

MS sucks in every conceivable way for most routine process QA/QC. Way more expensive, more downtime, more maintenance, more personnel needed, less accurate, less precise, needs more sample prep, etc etc. Great for research, great for trace work, terrible for most other stuff.

We are talking well defined manufacturing processes where you are looking at the same peaks all day every day (all research already done) on your multi kilo batches (thus no trace work either).

So what do you think? Applicable at home?

 

[janoshik]

So what do you think? Applicable at home?

HPLC-UV - most definitely, that's how I ran it for a while

Hell, I even ran an MS out of my place years ago.

Small scale synthesis? Doable too, but massively not worth it.

GH manufacture? Nope.

 

[TRT]

HPLC-UV - most definitely, that's how I ran it for a while

Hell, I even ran an MS out of my place years ago.

Small scale synthesis? Doable too, but massively not worth it.

GH manufacture? Nope.

Ya I ment the manufacturing. Just curious.
Or maybe you want me to think that so I don't do it....Jaannnoo...you have something you wanna tell me?

Lol jk

 

[janoshik]

Ya I ment the manufacturing. Just curious.
Or maybe you want me to think that so I don't do it....Jaannnoo...you have something you wanna tell me?

Lol jk

Like I said, doable, massively not worth it. You'd pay like 1000% more per gram doing it yourself. economies of scale my man

 

[BarbellBaby1]

LC-UV is literally the most used technique in the industry by far and for a good reason

MS sucks in every conceivable way for most routine process QA/QC. Way more expensive, more downtime, more maintenance, more personnel needed, less accurate, less precise, needs more sample prep, etc etc. Great for research, great for trace work, terrible for most other stuff.

We are talking well defined manufacturing processes where you are looking at the same peaks all day every day (all research already done) on your multi kilo batches (thus no trace work either).

UV is what's so commonly used by our biochemists exclusively that I guess my side of things just assumes no one else uses it, my bad LOL.

I'm focused on synthetic methods and less on process scale so NMR is my baby all day, every day! I despise MS but it's the gold standard (at least in my neck of the world) when coupled with LC/HPLC. (NMR remains god-tier in my eyes)

 

[TRT]

Like I said, doable, massively not worth it. You'd pay like 1000% more per gram doing it yourself. economies of scale my man

Ya I know. Just teasing ya. Ha

 

[janoshik]

I'm focused on synthetic methods and less on process scale so NMR is my baby all day, every day! I despise MS but it's the gold standard (at least in my neck of the world) when coupled with LC/HPLC. (NMR remains god-tier in my eyes)

Yeah, I understand completely - that's how I was able to figure out that you're an academic! I still use NMR and HRMS a lot for nonroutine samples. And quite contrary to you I hate the NMR, as it takes incredible amount of time to interpret as I suck at it! Not even mentioning the queues.

 

[BarbellBaby1]

Yeah, I understand completely - that's how I was able to figure out that you're an academic! I still use NMR and HRMS a lot for nonroutine samples. And quite contrary to you I hate the NMR, as it takes incredible amount of time to interpret as I suck at it! Not even mentioning the queues.

I can read NMR spec so much faster than other forms of spec data but that's because I have to read so many daily lol. NMR queues...don't even get me started! Hats off to those of yall who handle the analytical side of things, I get unhappy if my head isn't in a fume hood lol

 

[janoshik]

I can read NMR spec so much faster than other forms of spec data but that's because I have to read so many daily lol. NMR queues...don't even get me started! Hats off to those of yall who handle the analytical side of things, I get unhappy if my head isn't in a fume hood lol

To each their own, I wouldn't synthetize jack even if I tried

cheers

 

[BarbellBaby1]

To each their own, I wouldn't synthetize jack even if I tried

cheers

Good chatting with you, sir. Cheers, as well!

 

[SwitchingUpFast]

Small scale synthesis? Doable too, but massively not worth it.

Can you tell us how it wouldn't be "worth it"?

 

[mochul]

Can you tell us how it wouldn't be "worth it"?

there is several side reactions that has to be taken into consideration and purified using hplc. Low yield on a low scale, expensive material needed for some of the more difficult steroids to make like primo or anavar and many more.

 

[SwitchingUpFast]

there is several side reactions that has to be taken into consideration and purified using hplc. Low yield on a low scale, expensive material needed for some of the more difficult steroids to make like primo or anavar and many more.

Don't wanna be a nagging bastard but what does the actual process look like? At what scale does it become profitable? I wanna see some numbers and equations.

 

[mochul]

Don't wanna be a nagging bastard but what does the actual process look like? At what scale does it become profitable? I wanna see some numbers and equations.

You can find some of the reactios to produce test, mast, tren and etc. But the costs all depends on which reaction your are going to use, the quality of equipments, methods to measure your the purity and etc. Chemist are traind for several years to perform such a tasks so there is no simple way to answer that.

 

[SwitchingUpFast]

You can find some of the reactios to produce test, mast, tren and etc. But the costs all depends on which reaction your are going to use, the quality of equipments, methods to measure your the purity and etc. Chemist are traind for several years to perform such a tasks so there is no simple way to answer that.

I can find several patents on the web but they don't really tell me shit. Who is the Walter White of this place? I really wanna learn yo

 

[SwitchingUpFast]

Could someone tag a user who's an actual chemist?

 

[SwitchingUpFast]

attention everyone @GreenAmine wants to tell us something

 

[SwitchingUpFast]

Turning Estradiol (which isn't even hard to get anymore because of the whole trans situation) into Nandrolon is very well possible, right?

 

[ThiccManJack]

Turning Estradiol (which isn't even hard to get anymore because of the whole trans situation) into Nandrolon is very well possible, right?

You can either A. spend $50 on 10g of Estradiol base from QSC and go through a huge chemical process, spending years on research and thousands on lab equipment along with hours and hours of work to synthesize small batches or you can B. spend $50 on 10g of NPP and brew it immediately with less than 20 IQ.

 

[GreenAmine]

attention everyone @GreenAmine wants to tell us something

Meh, not particularly. Have fun with your "equations".