Have a reason to do it first, we dont know anything about your situation. 4 weeks is just long enough for you to have 250 a week hit peak serum level. Have your lifts stalled? Have you pushed up food but found no results? Where is your bloodwork now, how is your estrogen with a twice a week shot? IF you go to 500 are you going to everyday injections, or just add an AI? If you jump up to 500 at week 4 how far are you going to go up in dose for the coming weeks, will you have to cut it short cause you went up to far to fast and cant tolerate the side effects? Do you have all the ancillaries on hand when you find side effects to keep going? These are all things only you know and your goals should dictate your dosage. If all you want is some randos on the internet to encourage you to do more drugs the tren bros will find the thread shortly.
IMO, add 100mg a week when lifts stop going up after a deload or when more food just makes body composition worse. When you up the dose go to more frequent injections or add an AI, you might need both. oh and add gh, always have gh in there