Testosterone Suspension by heavyiron

[heavyiron]

Testosterone Suspension by heavyiron

Testosterone is the undisputed king of steroids mainly because it is safe, elicits rapid mass and strength gains while maintaining libido, a sense of well being and energy. It’s not uncommon for a first time user to gain 15-20lbs of LBM in a standard testosterone cycle.

Suspensions have tiny particles that are visible with the naked eye. If left on the shelf for a few days many times the particles will sink to the bottom leaving the clear solvents and water on the top. Depending on the manufacturer, particle sizes vary meaning some Suspension preparations can clog a 22 gauge needle. Ultra micronized Suspension can pass through a 25 gauge needle making injections more comfortable. Shake the suspension preparation vigorously before injecting.

Testosterone suspension is the most potent form of testosterone because it does not possess an ester. Esters are calculated into the steroid weight therefore esterfied steroids are not a true mg for mg of free hormone. 100mg of suspension is 100mg of free hormone! Enanthate in a solution is only 72mg of free hormone per 100mg. You can see that Suspension is the true king steroid. However because there is no ester many users will inject suspension everyday or even multiple times per day. This is usually reason enough for most people to reject using suspension but it gets worse. Usually suspension is quite painful as well. Combine every day injections with significant pain and most users simply pass on trying suspension at all. Some new science now demonstrates that everyday and even every other day injections are not necessary with Testosterone Suspension.

What is the real half life of Testosterone Suspension?

There is no classic half life of aqueous Testosterone Suspension due to the nature of the various suspension particle sizes and the non existence of an ester. In other words we don’t see the same types of decay rates with blood androgen levels in non esterfied preparations that are seen in esterfied preparations. However in March of 2011 there was a pharmacokinetics study done in horses that reported a median terminal half-life of 39 hours with aqueous Testosterone Suspension.(1) The disposition of testosterone from this formulation was characterized by an initial, rapid absorption phase followed by a much more variable secondary absorption phase. There were at least two plasma testosterone concentration peaks. The first peak is almost immediate and the second peak is a whopping 7 days later on average according to the chart in the full study. The study indicates that the initial peak is from the Testosterone formulation solution and the following peak(s) from the solid material in the suspension.



Basically the solution almost immediately hits the blood stream when injected and then a few days later the solid particles are slowly absorbed by the body causing other peaks in testosterone blood androgen levels.

So how often should you administer Suspension?

Based on this science, injecting Suspension every other day or even every three days will maintain high blood androgen levels. The king of steroids has had a time release delay built into it all along and we have the data to prove it. 100mg every other day would be a good starting dose for newer male users. More advanced male users could easily double that dose for very rapid and pronounced LBM gains. Suspension is moderately estrogenic and that effect will be dose dependant. The more you administer the more likely aromatase activity will occur. I would use Nolvadex to lower estrogenic side effects or an aromatase inhibitor.

Sample 8 week cycle

Sunday 20mg Nolvadex
Monday 150mg Suspension/20mg Nolvadex
Tuesday 20mg Nolvadex
Wednesday 150mg Suspension/20mg Nolvadex
Thursday 20mg Nolvadex
Friday 150mg Suspension/20mg Nolvadex
Saturday 20mg Nolvadex

Nolvadex is used to keep lipids positively influenced for those concerned with cardiovascular health. I have opted for an injection schedule of only three times per week to allow for comfort and because a more frequent schedule is not needed.

This cycle should produce rapid increases in strength and mass. I would use this cycle during a bulking phase. A more adventuresome user could stack a strong oral like Anadrol or Dianabol with the above cycle at 50mg daily producing an amazing and rapid increase in power, size and strength if nutrition, training and recovery are dialed in.


Reference

An interlaboratory study of the pharmacokinetics of testosterone following intramuscular administration to Thoroughbred horses.

 

[MR10X]

I did 100mg of test sus everday and it was too much,side effects were very agressive.I cut back to 50mg a day and this was a good dose for me.

 

[MR10X]

I did 100mg of test sus everday and it was too much,side effects were very agressive.I cut back to 50mg a day and this was a good dose for me..........................................

 

[BBC3]

I read this in the other thread. It is my suspicion that we are dealing with a shitty study, and what is happening here is ONE SINGLE injection applied to an animal with no recent steroid history with regard to regularity or current HPTA inhibition. So you would have the second peak occurring as the horses natural production kicked back in once SynT falls to a certain level. Thats a guess on a light skim of the article.

I dont see how this could provide any merit to steroid use in human BB or TRT though. There is no question that steady state if FLAT OUT juiced up once pinning any ester regularly. This curve does not exist, and the thread becomes banther once the subject is applied to the application studied at this site. Sorry, just looks like you forced that one and it provides confusion as all I can tell. No one else said it SO IT DID....

Just keepin it straight, sorry if I missed something, and will take my lashings if deserved.

 

[Bill Roberts]

Well, the horses were geldings (castrated) or both geldings and mares, I don' t recall, and the second peak was far higher than the starting point, so for these reasons myself I wouldn't attribute the second peak to natural production.

 

[heavyiron]

I read this in the other thread. It is my suspicion that we are dealing with a shitty study, and what is happening here is ONE SINGLE injection applied to an animal with no recent steroid history with regard to regularity or current HPTA inhibition. So you would have the second peak occurring as the horses natural production kicked back in once SynT falls to a certain level. Thats a guess on a light skim of the article.

I dont see how this could provide any merit to steroid use in human BB or TRT though. There is no question that steady state if FLAT OUT juiced up once pinning any ester regularly. This curve does not exist, and the thread becomes banther once the subject is applied to the application studied at this site. Sorry, just looks like you forced that one and it provides confusion as all I can tell. No one else said it SO IT DID....

Just keepin it straight, sorry if I missed something, and will take my lashings if deserved.

Thank you for sharing your thoughts.

I think the study makes pretty good sense. The solution spikes blood androgen levels then the next spike is from the solid particles in the suspension being absorbed. In other words, the solid particles would not be immediately and completely absorbed by the body so a subsequent peak makes sense.

The active life is pretty long though so I'm open to the idea that it takes horses longer to process the Testosterone.

Your idea of the horse's natty kicking in seems kind of unrealistic to be honest. The spikes are well above the baseline norm as far as I can tell. Especially the second one around day 7.

 

[BBC3]

See BR's reply above.. Coincidental timing I think. No idid not see the neutering.

With that considered you would have to attribute the second release to the "breaking point" of the ester. Or the time at which the majority, which went to fat on injection, finally met esterase activity. This makes perfect sense. This is my whole concept below. We have discussed in the past. Esters are undervalued in their real effect. Still I am talking without a good read of the study. So I will just offer some food for thought.

I am not disagreeing that I think there is an influx of availability at the time of injection, and the cypionate (per say) will migrate directly into circulation to some degree. The ester length will determine how quickly and how much goes to "fat", or is held in the muscle. It is note accurate to think of it as "powder" or "Crystals" as any point. This is just another state of a fluid. But the problem is that in a BB, systems are already saturated and the point is moot.

I do not intend any shittyness. I just have always considered it my goal to keep meso as technically correct as possible. AND I Have been wrong many times. I eat my crow on occasion.

But I am not sure we are talking apples and apples. Regardless my point was that I thought that it served no reference to real human application was all.

I have been round and round over "half lives" with regard to injectible esters is the reason the thread caught my attention. In short the whole concept of an injection of cypionate, per say, ahving a "half life" is a misnomer, or improper use of the term as it is standardly applied in medicine. Half-life really refers to the drugs life in the blood once circulating. Like taking an asprin per say. When you are dealing with esterfied solubles, you are talking MANY HOOPS to even get there. Three basic point breaks are:
1) The injection is pinned to human muscle/sleletal. At this point it saturates into fat depending on the given lenth of the ester molecular chain will determine how fast it GOES IN and RELEASES.
2) Next you have the conversion to unesterfied testosterone via the esterase component. The Tcyp molecule has to come into contact with this to release from ester and be available as testosterone in the blood.
3) Then you have the whole process by which it survives in the blood. A relatively quick on ONCE unbound from SHBG. That reminds me if Bill is reading. Does synT actually BIND to SHBG once released from ester? I am pretty sure it does.

So the TECHNICAL HALF LIFE of Testosterone is minutes. The true half life of an esterfied testosterone can vary from days to 3 plus months. It is just poor cycling to use more than Prop IMO. It should further and finally be noted that there is another stage in the 3 phase release process I detailed that I did not mention. This is the fact that one of the functions of BB in the solution, other than as a secondary solvent, is to help the injection bind to the muscle group. The release time is 1-2 days for this factor. Hence some reported knotting and swelling can also be attributed to this. Really, I may have stated that improperly. BB helps the injection to SATURATE INTO THE MUSCLE GROUP so that it will be there with longer opportunity for the ester to go into fat holding. So the BB adds some of the PUNCH to the and thus the DEPOT.

There are also all kinds of other issues like muscle saturation and local fat levels to consider. ANY DEPOT should be rotated vigorously to ensure MAXIMUM DISPERSEMENT AVAILABILITY. This whole concept becomes mooted by the fact that sooner or later the blood is saturated beyond what demands call for. The longer the ester, the longer the time to blood saturation. HOWEVER, YOUR POINT about immediate absorption helps to alleviate this time in real world application. And there is alway leakage out of the muscle and not many PIN perfectly. One of the benefits of multiple injection points however, is that it will help to prevent excess SHRINKAGE into immediate circlation of pins. I SUSPECt the more a muscle becomes saturated, then the less it will hold what is put in it. Then the depot must immediately migrate to other areas, fat, or circulation. Circulation is almost 100% immediately discarded as it is a zillion times more than one could used on a dime.. This is the negative side to your point.

No disrespect intended. Just keeping it up...

Thank you for sharing your thoughts.

I think the study makes pretty good sense. The solution spikes blood androgen levels then the next spike is from the solid particles in the suspension being absorbed. In other words, the solid particles would not be immediately and completely absorbed by the body so a subsequent peak makes sense.

The active life is pretty long though so I'm open to the idea that it takes horses longer to process the Testosterone.

Your idea of the horse's natty kicking in seems kind of unrealistic to be honest. The spikes are well above the baseline norm as far as I can tell. Especially the second one around day 7.

 

[heavyiron]

See BR's reply above.. Coincidental timing I think. No idid not see the neutering.

With that considered you would have to attribute the second release to the "breaking point" of the ester. Or the time at which the majority, which went to fat on injection, finally met esterase activity. This makes perfect sense. This is my whole concept below. We have discussed in the past. Esters are undervalued in their real effect. Still I am talking without a good read of the study. So I will just offer some food for thought.

I am not disagreeing that I think there is an influx of availability at the time of injection, and the cypionate (per say) will migrate directly into circulation to some degree. The ester length will determine how quickly and how much goes to "fat", or is held in the muscle. It is note accurate to think of it as "powder" or "Crystals" as any point. This is just another state of a fluid. But the problem is that in a BB, systems are already saturated and the point is moot.

I do not intend any shittyness. I just have always considered it my goal to keep meso as technically correct as possible. AND I Have been wrong many times. I eat my crow on occasion.

But I am not sure we are talking apples and apples. Regardless my point was that I thought that it served no reference to real human application was all.

I have been round and round over "half lives" with regard to injectible esters is the reason the thread caught my attention. In short the whole concept of an injection of cypionate, per say, ahving a "half life" is a misnomer, or improper use of the term as it is standardly applied in medicine. Half-life really refers to the drugs life in the blood once circulating. Like taking an asprin per say. When you are dealing with esterfied solubles, you are talking MANY HOOPS to even get there. Three basic point breaks are:
1) The injection is pinned to human muscle/sleletal. At this point it saturates into fat depending on the given lenth of the ester molecular chain will determine how fast it GOES IN and RELEASES.
2) Next you have the conversion to unesterfied testosterone via the esterase component. The Tcyp molecule has to come into contact with this to release from ester and be available as testosterone in the blood.
3) Then you have the whole process by which it survives in the blood. A relatively quick on ONCE unbound from SHBG. That reminds me if Bill is reading. Does synT actually BIND to SHBG once released from ester? I am pretty sure it does.

So the TECHNICAL HALF LIFE of Testosterone is minutes. The true half life of an esterfied testosterone can vary from days to 3 plus months. It is just poor cycling to use more than Prop IMO. It should further and finally be noted that there is another stage in the 3 phase release process I detailed that I did not mention. This is the fact that one of the functions of BB in the solution, other than as a secondary solvent, is to help the injection bind to the muscle group. The release time is 1-2 days for this factor. Hence some reported knotting and swelling can also be attributed to this. Really, I may have stated that improperly. BB helps the injection to SATURATE INTO THE MUSCLE GROUP so that it will be there with longer opportunity for the ester to go into fat holding. So the BB adds some of the PUNCH to the and thus the DEPOT.

There are also all kinds of other issues like muscle saturation and local fat levels to consider. ANY DEPOT should be rotated vigorously to ensure MAXIMUM DISPERSEMENT AVAILABILITY. This whole concept becomes mooted by the fact that sooner or later the blood is saturated beyond what demands call for. The longer the ester, the longer the time to blood saturation. HOWEVER, YOUR POINT about immediate absorption helps to alleviate this time in real world application. And there is alway leakage out of the muscle and not many PIN perfectly. One of the benefits of multiple injection points however, is that it will help to prevent excess SHRINKAGE into immediate circlation of pins. I SUSPECt the more a muscle becomes saturated, then the less it will hold what is put in it. Then the depot must immediately migrate to other areas, fat, or circulation. Circulation is almost 100% immediately discarded as it is a zillion times more than one could used on a dime.. This is the negative side to your point.

No disrespect intended. Just keeping it up...

I must admit I'm having a hard time following your flow of thought. Do you think Suspension has an ester? It seems like you are making a point with this assumption.

 

[BBC3]

No just ranting today ripped on thought provoking drugs and moving too fast to read like I should.

Sorry. did not realize. I thought I saw somewhere where someone referred to an esterfied testosteone.:drooling::drooling:

See I told ya I like the taste of CROW...

So then the premise is a spike related to a neutered horse with straight up t suspension? Then why the hell did the chart refer to days or weeks. Was that hours??:drooling:

I stand.... Uhh.. As the jackass I am.

OK, I just looked again. Suspension has NO life span. They have to be talking pellets....

I must admit I'm having a hard time following your flow of thought. Do you think Suspension has an ester? It seems like you are making a point with this assumption.

 

[BBC3]

Further I am gathering they are referring to bacally shooting micro pellets into a rump as powder in form? Am I on the page now. That would be painful. I always assumed that when people used this type testosterone, it was basicall at least in full liquid solution... Looking at the pics I see a lot of granule...?!?!? I would think it would need to be diluted down further than that as I pictured. it.

Sorry just running too fast today. So I am now the learner. Are you guys sayiing that unesterfied testosterone survives in muscle for weeks as a water based injection.??

That also certainly seems like the risk of a thrombosis if hitting a big blood vessel...?

 

[bigrobbie]

Heavyiron, thanks for the profile. I'm glad you referenced the active steroid percentage of a base steroid w/o an ester attached vs a steroid that has an ester attached. That is a great point that many newer guys may not realize.

Do you use Test suspension pre workout? Always wanted to run a cycle that includes something like 50mg test suspension pre workout...

 

[BBC3]

I am not sure if I get it. I dont have experience with this personally, but I dont see any benefit other than pain I suspect. This brings some realization to mind as this is my first real close look at this.

So it looks like we have raw testosterone in an solution of H20. It looks chunky and NASTY. Clearly it IS meant for animals.

BASICALLY it is the same concept as crunching up a pellet, less any binders, and adding some water and pinning it. PACKING YUR ASS WITH POWDER SO TO SPEAK[)] I dont even really see any benefit over what injecting a prop, or cyp for that matter, as there is PLENTY of instant gratification in the immediate impact of those. Obviously the concept IS FASTER and the data reveals a level of almost 1000ng/dl at the first day. I would like to point out these are serum levels and that should vary based on the individuals experience and capabilities.

So alright, interesting enough. Technically I am thinking it looks to perform in metabolism similar to Prop. The only question is which would be more painful....[)]

So Structure I apologize for shooting off prior to the read. Pehaps someone gained something. I will say that you did respond with a very well and reserved approach to my over the top interjection and applaud you for that. Clearly you have been well chosed as a MOD here. So, carry on Ol' Son. It is a very informative thread and educational in that I have not seen this concept addressed here before that I know of.... Nice .

Heavyiron, thanks for the profile. I'm glad you referenced the active steroid percentage of a base steroid w/o an ester attached vs a steroid that has an ester attached. That is a great point that many newer guys may not realize.

Do you use Test suspension pre workout? Always wanted to run a cycle that includes something like 50mg test suspension pre workout...

 

[heavyiron]

Heavyiron, thanks for the profile. I'm glad you referenced the active steroid percentage of a base steroid w/o an ester attached vs a steroid that has an ester attached. That is a great point that many newer guys may not realize.

Do you use Test suspension pre workout? Always wanted to run a cycle that includes something like 50mg test suspension pre workout...

You are very welcome.

I used it for a bit but not consistently. The thought of constant pins and the clogged needles got old fast but now looking at this data I'm inclined to use it again with less frequent injects.

 

[heavyiron]

I am not sure if I get it. I dont have experience with this personally, but I dont see any benefit other than pain I suspect. This brings some realization to mind as this is my first real close look at this.

So it looks like we have raw testosterone in an solution of H20. It looks chunky and NASTY. Clearly it IS meant for animals.

BASICALLY it is the same concept as crunching up a pellet, less any binders, and adding some water and pinning it. PACKING YUR ASS WITH POWDER SO TO SPEAK[)] I dont even really see any benefit over what injecting a prop, or cyp for that matter, as there is PLENTY of instant gratification in the immediate impact of those. Obviously the concept IS FASTER and the data reveals a level of almost 1000ng/dl at the first day. I would like to point out these are serum levels and that should vary based on the individuals experience and capabilities.

So alright, interesting enough. Technically I am thinking it looks to perform in metabolism similar to Prop. The only question is which would be more painful....[)]

So Structure I apologize for shooting off prior to the read. Pehaps someone gained something. I will say that you did respond with a very well and reserved approach to my over the top interjection and applaud you for that. Clearly you have been well chosed as a MOD here. So, carry on Ol' Son. It is a very informative thread and educational in that I have not seen this concept addressed here before that I know of.... Nice .

No worries brother, all views are welcomed!