The 5 Types of Hyperlipidemia Drugs

6tren

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Currently taking notes in Pathophysiology class and came across this new info I didn't know about, maybe it can help. Below is copy and pasted from lecture.

"There are currently five types of hyperlipidemia drugs: HMG CoA reductase inhibitors (statins), bile acid-binding resins, cholesterol absorption inhibitor agents, niacin, and the fibrates.

HMG CoA inhibitors (e.g. atorvastatin, rosuvastatin, simvastatin) reduce or block the hepatic synthesis of cholesterol. They are usually the first-line treatment of LDL-reducing therapy. Statins also reduce triglyceride levels and increase HDL levels. They have been shown to reduce the risk for acute coronary syndromes and stroke in secondary prevention.

The bile acid-binding resins (e.g. cholestyramine, colestipol, colesevelam) bind and sequester cholesterol-containing bile acids in the intestine. This leads to increased production of LDL receptors by the liver, and increased removal of cholesterol from the blood for synthesis of new bile acids. These agents are used as adjunct to statin therapy for patients requiring further reductions in LDL and a 3-5% increase in HDL.

Nicotinic acid, or niacin (vitamin B3), blocks the synthesis and release of VLDL by the liver. This lowers VLDL, IDL, and LDL levels. It increases HDL levels 15% to 35%. Flushing and headache are common side effects of niacin.

The fibrates (e.g. fenofibrate and gemfibrozil) also decrease the synthesis of VLDL by the liver. They increase the clearance of triglycerides from the circulation which causes a decrease of 20-50% of triglycerides."
 
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