This is from an internal document from a butyl rubber vial plug manufacturer:
"Particles can cause vascular embolism, allergic reaction, phlebitis, microcirculatory blockage, thermogenic reaction, arteriosclerosis, granuloma, pulmonary embolism and other adverse reactions butyl plugs are one of the main factors of particle contamination of infusion preparations,"
At present, there are two main types of halobutyl rubber commonly used in the production of pharmaceutical stoppers internationally: chlorobutyl rubber and bromobutyl rubber.
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