Thyroid problem (High TSH, High T3 and T4)

[Gabor006]

I would like to ask for help in figuring out what the hell happened with my thyroid hormones. I have been using 300mg test e, 300mg npp and 25mg proviron(I dropped npp recently) for at least 6 months (npp for only like 1-1,5 month) and my thyroid hormones got out of whack recently(around 2-3weeks ago). I cannot gain weight on calories that I could get fat with.

My estrogen shot through the roof which I managed to bring down with exemestane and my thyroid hormones instantly improved but they are still elevated and kind of like a paradox since my TSH is elvated but so as my T4 and T3 which doesnt really make sense. Ill attach my most recent blood works. One with the higher estrogen and tsh and one with 5 days later with lowered estrogen and tsh. Even though they are in hungarian language some of the marks can be understood for non hungarians.

It came to my mind that it might be mineral or some kind of vitamin deficiency. (I am taking iron(even though my iron is really low),c vitamin, d vitamin, zinc+copper, d3 k2,artichoke+milk thistle, nattokanise enzym, fish oil, hawthorn+garlic complex,black cranberry, q10 coenzym,Serrapeptase, Kolin & Inozitol, Astragalus & Echinacea, NAC, TUDCA) but I highly doubt it. Only selenium comes to my mind that might be the root of the problems.

It also seems that estradiol had a huge impact on it but it is still high even after lowered values. I dont really know where to now if should I just wait a month and check again or do something about it to fix it.

Testosterone is 104 nmol/l (it doesnt show on bw)
Estrodial 408 to 96
TSH 6.8 to 4.3
T4 19.7
T3 7.5
(five days has passed between the 2 blood work)

I would be grateful for some help or pointers since I am stuck at a certain weight and cant get past it no matter if I am in 1000+ calorie surplus or 500. (It is not the case that I cannot weight my food or I eat less than I think)

Id like to add that it has never happened before even if my estrogen got high, this is totally a new thing that my body has done.

 

[Jaxino]

To speak frankly, my friend, I would strongly advise consulting an endocrinologist, as it appears you may be developing certain thyroid-related issues.

It is also possible that NPP was previously misinterpreted as elevated estradiol in your earlier bloodwork, so I would not be overly concerned about that particular point.

As for supplementation, iron and B vitamins may indeed prove useful; however, this requires further testing. The underlying cause could be iron-deficiency anemia—or perhaps not. It is equally important to consider whether there is any occult blood loss in the stool. In my own case, when I suffered from Helicobacter pylori infection, my iron levels plummeted to the extent that my hemoglobin dropped to 7. Recovery from anemia is an arduous and prolonged process—do not underestimate it.

That said, the combination of elevated FT3, FT4, and TSH is most commonly associated with thyroid hormone resistance, a condition that is admittedly quite rare.


About the second bloods Chatgpt said that:

I’m looking at the results of an endocrinology panel. Here’s a clear summary of the values compared to the reference ranges:

TSH (thyroid-stimulating hormone): 4.373 mIU/L
Slightly above the reference range (0.480 – 4.170).

Free T4 (thyroxine): 19.7 pmol/L
Above the range (10.7 – 18.4).

Free T3 (triiodothyronine): 7.5 pmol/L
Above the range (4.7 – 7.2).

Estradiol (E2): 96.7 pmol/L
Within normal limits (reference < 146.1).



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Interpretation (general, not a substitute for medical consultation):

Elevated TSH together with elevated FT3 and FT4 is an atypical pattern.

Normally, when FT3 and FT4 are high, TSH is suppressed (classic hyperthyroidism).

In this case, TSH is slightly elevated alongside high thyroid hormones → this could suggest thyroid hormone resistance or a problem at the pituitary level (for example, a TSH-secreting pituitary adenoma).


Estradiol is normal.


What this means for you:
These results definitely require evaluation by an endocrinologist, because this is not the typical pattern of either simple hypo- or hyperthyroidism. It may reflect a rarer condition or a transient situation, but it needs clinical interpretation in light of your symptoms, medical history, and possibly further tests (pituitary MRI, thyroid antibodies, etc.).

 

[eryximachus]

Ex-girlfriend had that and had a tumor that had to be removed. Just slight elevations. Definitely need a doctor.

 

[Jaxino]

Ex-girlfriend had that and had a tumor that had to be removed. Just slight elevations. Definitely need a doctor.

Also my ex, but her values were like 10 times the max range. Her FT3 FT4 were skyhigh, TSH normal.