Tirz Fatigue - solid AAS cycle can help maybe?

[eryximachus]

I've been feeling fatigued since starting tirzepatide. I am on TRT only currently but have gear around ready to ramp up. I've been reading on reddit this is a common problem, and a purported benefit of retatrutide. I had been clinging to my med spa providing Tirz, but I'm at the point where I'm considering all options to help with the fatigue. Switch up the meds, ditch the meds, start an amping cycle, and so on.

Anyone else getting Tirz fatigue? Does it possibly go away once you hit 10+mg?

 

[Spaceman Spiff]

I've been feeling fatigued since starting tirzepatide. I am on TRT only currently but have gear around ready to ramp up. I've been reading on reddit this is a common problem, and a purported benefit of retatrutide. I had been clinging to my med spa providing Tirz, but I'm at the point where I'm considering all options to help with the fatigue. Switch up the meds, ditch the meds, start an amping cycle, and so on.

Anyone else getting Tirz fatigue? Does it possibly go away once you hit 10+mg?

I assume it's partially the body also fighting back against being caloric deficit

 

[Here2Learn]

I added .5mg of Reta to help which worked for me. My exhaustion wasn’t nearly as bad on T as it was on Sema though. I was completely non functioning, but had great appetite suppression so there’s that. Lol

 

[Ghoul]

It's from the sudden calorie deficit without the body having time to adjust. The fatigue goes away as metabolism adjusts over a couple of months. The reason the Reddit geniuses have concluded Reta doesn't is because by the time they switch they've already begun to get used to the lower calorie intake.

 

[BamaCrazy]

I wouldn’t called it exhaustion as much as I would call it lethargy. Once I started lifting or mountain biking I felt fine. But getting started was difficult. After 5 months of Tirz I added 2mg Reta 3 days after my Tirz shot. That same day Reta resolved my issue. I slowly replaced Tirz with Reta. I think Reta is best for people who are active.

 

[Here2Learn]

It's from the sudden calorie deficit without the body having time to adjust. The fatigue goes away as metabolism adjusts over a couple of months. The reason the Reddit geniuses have concluded Reta doesn't is because by the time they switch they've already begun to get used to the lower calorie intake.

I don’t know, I was on Sema for 5 months and could hardly function I was so tired. Each week it just kept getting worse I could not go up in dose. Switched to Tirz and it was instantly a lot better, added the small amount of Reta and I feel good.

 

[Ghoul]

What's impressive to observe among the Reddit weight loss peptide groups, besides people needlessly turning themselves into guinea pigs exposed to risks they're completely unaware of, is the psychological phenomenon of mass "folie à deux", aka shared delusions.

Setting aside the fact all of these drugs work just fine to provide significant, sustained weight loss without stacking or administering multiple times a week, but this "fatigue solved by Reta" claim.

Dive into the clinical trials, involving thousands of closely monitored users, and it's clear Reta induces a more rapid loss of weight, and as expected, a HIGHER rate of fatigue than Tirz, in line with the more rapid reduction in calorie intake.

 

[Trenbolonetax]

I got higher fatigue / lethargy on tirz compared to Reta. Love Reta.

 

[Here2Learn]

What's impressive to observe among the Reddit weight loss peptide groups, besides people needlessly turning themselves into guinea pigs exposed to risks they're completely unaware of, is the psychological phenomenon of mass "folie à deux", aka shared delusions.

Setting aside the fact all of these drugs work just fine to provide significant, sustained weight loss without stacking or administering multiple times a week, but this "fatigue solved by Reta" claim.

Dive into the clinical trials, involving thousands of closely monitored users, and it's clear Reta induces a more rapid loss of weight, and as expected, a HIGHER rate of fatigue than Tirz, in line with the more rapid reduction in calorie intake.

I have read quite a few studies and have not seen fatigue on the list of side effects they are tracking % of participants reporting. The attached picture is from one of the studies. Now I admit I have not read all of the studies but definitely have dug fairly deep and haven’t seen it listed yet.

 

[Trenbolonetax]

I have read quite a few studies and have not seen fatigue on the list of side effects they are tracking % of participants reporting. The attached picture is from one of the studies. Now I admit I have not read all of the studies but definitely have dug fairly deep and haven’t seen it listed yet.

Your experience won’t be the same as everyone elses, and vice versa. If it works for you, that’s awesome - you should keep doing it imo. Even if the studies contradict your experience, shouldn’t just follow the studies cuz they’re studies - you should go with what is working for you.

 

[Here2Learn]

Your experience won’t be the same as everyone elses, and vice versa. If it works for you, that’s awesome - you should keep doing it imo. Even if the studies contradict your experience, shouldn’t just follow the studies cuz they’re studies - you should go with what is working for you.

I think the main takeaway I have come up with is everyone responds differently to each one of the available options. Which of course makes perfect sense. What works for one may have the complete opposite effect on another. I use the studies to try and make informed decisions on what I am doing.

 

[Trenbolonetax]

I think the main takeaway I have come up with is everyone responds differently to each one of the available options. Which of course makes perfect sense. What works for one may have the complete opposite effect on another. I use the studies to try and make informed decisions on what I am doing.

Absolutely. The studies can help guide the initial decision making process, but they’re not the end all be all.

 

[bjjgear]

A solid AAS cycle could make things far worse

 

[TedStriker]

I never got to a high tirz dose. Most was 7.5 then tapered down slowly. Even at that, I did experience the lethargy you speak of. I, too, could tough it out once I "got moving" but would still suffer from hypotension-like symptoms occasionally. I've played around with some different aminos and such (Lipo-C shots, B-12 shots, etc...) with maybe SOME anecdotal improvement. Even at my peak dosage, I tried to get an absolute BARE minimum of 100g protein per day, and that seems to help.

 

[UncleBuns]

Don't take any PED/GLP 1 advice from Reddit. It's 90% bullshit on there. From what I've seen, most of it is an echo chamber where people convince themselves of nonsense and then repeat it constantly. There are some smart people on there with good information but you have to wade through so much BS it's not worth the effort.

 

[thejumpingsheep]

My experience with Tirz is that I had no fatigue till about 8 months in when I plateaued. At that point I was at 10mg and I stopped losing weight for about 4 months. This coincided with the feeling of fatigue. Since then its been fatigue all the time and I have to force myself to work out.

I stopped Tirz about 10 days ago to see what happens. So far my appetite doesnt seem to have changed or at least not that I cant tell. I definitely get full quick and eat less than I used to pre-Tirz but im not longer certain if thats due to Tirz or just because im more healthy. Hard to say. But even without Tirz the last 10 days, I still feel pretty tired. Im not sure how long Tirz takes to clear up but I plan to give it a full month before re-evaluating.

 

[UncleBuns]

My experience with Tirz is that I had no fatigue till about 8 months in when I plateaued. At that point I was at 10mg and I stopped losing weight for about 4 months. This coincided with the feeling of fatigue. Since then its been fatigue all the time and I have to force myself to work out.

I stopped Tirz about 10 days ago to see what happens. So far my appetite doesnt seem to have changed or at least not that I cant tell. I definitely get full quick and eat less than I used to pre-Tirz but im not longer certain if thats due to Tirz or just because im more healthy. Hard to say. But even without Tirz the last 10 days, I still feel pretty tired. Im not sure how long Tirz takes to clear up but I plan to give it a full month before re-evaluating.

The tricky part about knowing if the fatigue is actually from the Tirz is that calorie deficit and cutting can cause fatigue and the deeper you are in deficit and the more you cut the more pronounced the fatigue becomes. I think a lot of people generally will attribute any negatives they are experiencing with drugs they are taking before they look at other things that could be causing the side effects. You'll often see comments from people who strain a muscle or get the flu and they start a thread because they think it is caused by a compound they are taking and not just that they strain themselves or got sick. Just because we are taking a drug doesn't mean all the normal things of life don't occur for very normal reasons.

When I start cutting I get fatigue. When I get to about the 50% mark and the closer I get to goal weight the more the fatigue and general bad mood accelerates. I really wish there was a way to eliminate that part of cutting but I haven't found it. I bet most people's fatigue is from calorie deficit more than Tirz.

 

[niqTM]

I never got to a high tirz dose. Most was 7.5 then tapered down slowly. Even at that, I did experience the lethargy you speak of. I, too, could tough it out once I "got moving" but would still suffer from hypotension-like symptoms occasionally. I've played around with some different aminos and such (Lipo-C shots, B-12 shots, etc...) with maybe SOME anecdotal improvement. Even at my peak dosage, I tried to get an absolute BARE minimum of 100g protein per day, and that seems to help.

What did you experience with Lipo-C? I just recieved some Lipo-C 216 today and was pumped to try it when I started a GLP1 again to try to combat my lethargy.

 

[TedStriker]

What did you experience with Lipo-C? I just recieved some Lipo-C 216 today and was pumped to try it when I started a GLP1 again to try to combat my lethargy.

It's hard to say, but I think just a little more energy overall, but nothing magical. Some people swear by it, I figured I'd try it out because it's not expensive.