topical anti androgens ?

[just some dude]

topical anti-androgens seem appealing because you think you will get the benefits of oral fin/dut without the consequences of oral fin/dut.

however, have any of them actually done anything for anyone here? have you noticed meaningful progress since you’ve implemented topical solution(s)?

personally:
i’m not seeing as aggressive results as i wanted with oral dut + topical minoxidil, i’m thinking of adding oral minoxidil and topical anti-androgens

edit: this is about hairline / hair loss treatment - there’s a lot of data on minoxidil, dut, & fin, but not enough on some of these topical anti-androgens; they could def use more anecdotal evidence. for example ru-58841, some people saying it’s kept their hair for years, others swearing it off with chest pains. there’s not as much objective information on them it seems.

 

[Ghoul]

topical anti-androgens seem appealing because you think you will get the benefits of oral fin/dut without the consequences of oral fin/dut.

however, have any of them actually done anything for anyone here? have you noticed meaningful progress since you’ve implemented topical solution(s)?

personally:
i’m not seeing as aggressive results as i wanted with oral dut + topical minoxidil, i’m thinking of adding oral minoxidil and topical anti-androgens

Problem I have with topical anti androgens is variability in systemic effects. Unlike minoxidil, there are potential serious consequences to variability in absorption of a 5-ar inhibitor. I think it’s best to go oral so you always have precise control over the dose.

As far as topical minox, a pretty substantial minority have insufficient, or even none, of the enzyme required to convert it to the active form as it penetrates skin, so its effectiveness is diminished or eliminated entirely,

Oral is converted to active form 100% in everyone. Just have to give any sides some time to subside, if they occur. A lot cheaper and far less time consuming too.

Best clinically proven hair loss prevention and regrowth is via Dut/Minox combo. Boring but highly effective over time.