If hormonal balance and ratio was a thing every time we have 5000 TT we’d need 10x the estradiol, 10x prolactin, 10x progesterone, 10x DHEA, and so on but that’s not the case. Why do we stand specifically at estradiol? I’ve seen many guys with a gram of test and a e2 of 40 and they’re fine.
For me the two main issues from high e2 are first and foremost the higher chances for prostate cancer and second, the higher the e2 is the easier it gets to add fat in certain body parts like hips, glutes and stomach. Probably due to being mostly a female hormone as females need to be covered with a layer of fat due to their reproductive system.
I’m trying to not be dogmatic but so far I haven’t seen any research or any legit scientist giving one single reason why high estradiol in men could have any benefits. On the contrary, there’s research paper saying high estradiol increase the risk of prostatic cancer.
Also, ~50 is my upper preferred number and it is for reference. I know many guys that can’t go above 35-40 without side effects. I felt the same with 40-50-100, but around 40-50 is where I aim.