Two question

[ganciodestro]

Hi guys, I have two questions, the first is what is the difference in action between clomiphene and enclomiphene?

if I wanted to add to maintain fertility (hmg Is too expensive) and try to give a wake-up call to my testicles which even if I use hcg it doesn't seem to work, would the addition of clomid ED be together with the hcg and testosterone dosagei from trt?

If so, what dosage of clomid should I take and for how long?

currently my trt:
200 MG TESTO WEEKLY
600 IU of HCG EOD

 

[ganciodestro]

Bump

 

[bigpoppachump2]

Can someone help a brother out over here?

 

[Grey Spartan]

I use hcg it doesn't seem to work

What dose and how frequent?

I switched to 300iu EOD (every other day) and it made a HUGE difference. Before I was taking what the Doc suggested, 400iu twice a week and it didn't do much. It should be noted that I use the expensive as shit pharma HCG but that should not make a difference.

 

[Type-IIx]

Hi guys, I have two questions, the first is what is the difference in action between clomiphene and enclomiphene?

if I wanted to add to maintain fertility (hmg Is too expensive) and try to give a wake-up call to my testicles which even if I use hcg it doesn't seem to work, would the addition of clomid ED be together with the hcg and testosterone dosagei from trt?

If so, what dosage of clomid should I take and for how long?

currently my trt:
200 MG TESTO WEEKLY
600 IU of HCG EOD

Hey bro, for starters I want to point you to Peter Bond's excellent article on this topic, Enclomiphene - A SERM That was Seeking FDA Approval for the Treatment of Hypogonadism

From the article:

As is the case for a lot of drugs, clomiphene is a racemic mixture. Which means as much as that it consists of a “left-handed” and “right-handed” type of the molecule. Typically only one of these stereoisomers, as it’s called, is the active compound. Which is the result of a better fit with the receptor it acts on. Much like how a glove only fits one of your hands and not the other, the “left-hand” type is more effective in binding to a “left-hand” receptor than the “right-hand” stereoisomer. Clomiphene consists of the stereoisomers zuclomiphene (pictured on the left) and, you’ve guessed it, enclomiphene (pictured on the right):

In general, zuclomiphene is viewed as functioning as an estrogen receptor agonist, whereas enclomiphene is viewed as a potent estrogen antagonist [7]. Enclomiphene can therefore be viewed as the active stereoisomer of clomiphene. The idea of enclomiphene, thus, is that you have something that might be more effective and safer than clomiphene. Although I guess the most important aspect is that Repros Therapeutics Inc. could patent its therapeutic use for the treatment of male hypogonadism.

So, essentially enclomiphene is the L-stereoisomer of Clomid's racemic mix, that is a pure ER antagonist in brain hypothalamus and pituitary regions, thus, it should more selectively modulate estrogen receptor to increase FSH, LH, and T.

What you propose is good, fine. You might use enclomiphene rather than clomiphene. The latter has been widely reported to cause vision and mood issues, and its use has fallen out of favor over the decades for these reasons.