SWALE said:
Thanks, HeadDoc. I had hoped you would bring your expertise to this thread.
So you inhibit cortisol production with PS?
I only recommend it in cases where cortisol is proven elevated. There are far too many poeple out there who suffer low cortisol secondary to chronic stress.
My review of cortisol and insomnia indicated that the relationship is inconsistent. The relationship between melatonin and insomnia is much clearer. When doxipin is prescribed for insomnia, cortisol levels decrease. The following showed an increase of cortisol with insomnia---but again I found other studies that indicated that cortrisol levels are not affected by insomnia. I just figure that some brain chemical must be associated with arousal in the middle of the night--why not cortisol?
Endocrinol Metab Clin North Am. 2002 Mar;31(1):15-36. Related Articles, Links
Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders.
Vgontzas AN, Chrousos GP.
Department of Psychiatry, Pennsylvania State University, College of Medicine, H073 500 University Dr., Hershey, PA 17033, USA.
axv3@psu.edu
Sleep is an important component of mammalian homeostasis, vital for survival. Sleep disorders are common in the general population and are associated with significant medical, psychologic, and social disturbances. Sleep, in particular deep sleep, has an inhibitory influence on the HPA axis, whereas activation of the HPA axis or administration of glucocorticoids can lead to arousal and sleeplessness. Insomnia, the most common sleep disorder, is associated with a 24-hour increase of ACTH and cortisol secretion, consistent with a disorder of central nervous system hyperarousal. Sleepiness and fatigue are very prevalent in the general population, and recent studies have demonstrated that the proinflammatory cytokines IL-6 and/or TNF-alpha are elevated in disorders associated with excessive daytime sleepiness, such as sleep apnea, narcolepsy, and idiopathic hypersomnia. Sleep deprivation leads to sleepiness and daytime hypersecretion of IL-6. Combined, these findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans.
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