MESO-Rx
Anabolic Steroids
using methylphenidate instead of caber for lowering prolactin
- Thread starter runway
- Start date
Mishka
Member
yea or use fentanyl instead of ibuprofen 
ChevChelios
Member
U joke tbh I always found good coke to be miles better than coffee both for stim but also for the side effects, only thing I don’t like is how much of that is getting cut with levamisole n that’s sumn you don’t want to be consuming but if you’re just selling it’s actually very useful (the cartel guys will fk each other over with that as it’s nearly identical both esthetically and molecularly to cocaine so even if one tries to do a purity check or tries to cook it up to see how much comes out the levamisole rocks up right with the rest of the coke) which means that they will be selling ’pure’ to each other n they will already have that shit in their bricks. Sorry for the rant but having been in a certain biz for years (a long time ago people don’t be acting extra) I can tell you so much shit you’d be surprised, just for anyone who is dumb enough to still be using coke in 2024 please don’t use the looks as a way to determine quality, it is rarely that way and usually the shit that looks like a piece of cheese is better than the shit that is all shiny n diamond like (n I can tell you that u don’t want to know why half of em are shiny when in reality they are shite)
ChevChelios
Member
Jk aside tho cocaine n methylphenidate have similar mechanisms of action (both are dopaminergic agonists with a reuptake inhibition on dopamine n norepinephrine mostly). I don’t know why OP wants to use that to lower prolactin (where did you read that shit mane?) as there are way better and safer ways to do so, if you’re using Ritalin on cycle your BP n other stuff will likely suffer n idk mane at that point fr find some good coke as if MP does that I’m sure the OG would too ahah
he-man 100
New Member
Prolactin spikes during sleep. You would have to take Ritalin before going to bed
ChevChelios
Member
Another reason why using Ritalin to lower prolactin is a pretty dumb idea (plus in general I’m still trying to understand the science behind that like OP where did you read that? I’m genuinely curious)
MPH is a dopamine reuptake inhibitor, more dopamine = lower prolactin, not sure why people pretend like its some crazy idea.
Juicedhead
Member
ritalin lowers prolactin? Bro why the fuck would you use ritalin to do that? Its not designed to do that. Just use a drug that is designed to lower prolactin. Isnt that obvious? Im just trying to understand wtf is actually going on here.
ChevChelios
Member
I’m aware of the pharmacokinetics of methylphenidate ahah I didn’t know that it would lower prolactin and tbh if your main point is just due to dopamine I’d say go with something that is more direct as a DRI can have other effects that will negate whatever benefit you think/would get from that, it’s literally one step away from pharma style coke n has some shitty sides including increasing cortisol, upping your BP n fking round with your adrenergic levels, by all means I’d be curious as to what your results would be but it’s not sumn I’d recommend (but I repeat I really enjoy the experimental nature of certain BBing things so I’m all for experimentation n doing trippy shit, you have my full support even though I think it’s not the best idea ahah)
ChevChelios
Member
Yeah I would agree ahah but hey he wants to experiment let him (ik this is a harm reduction forum so it’s probably not the best thing but hey we told him that it’s not the greatest idea n he would still probably try it out so I just hope he provides some good BW/results to tell us what n how everything went, be it shitty or amazing ahah)
nightprowler7
Well-known Member
I believe he was being sarcastic
ChevChelios
Member
One would assume so (n he could very well be trolling) but imo the guy is serious or he just wants an excuse to get tweaked on methylphenidate ahah either way I hope he posts the results as I’m curious as to what will happen, I bet he just starts taking it for fun n forgets to write about it n the supposed reason for starting to do so, that or he will post a page long comment detailing everything in a very ranty way as tweakers tend to do
Juicedhead
Member
yeah man hes probabaly just trying to tweak and wants to justify tweaking and tell his doc that he tweaks to lower prolactin. But to be real ive kind of done the same thing but with adderall i was like doc i cant focus can i get on adderall and she said yes and i said ok cool and i just tweaked for a couple months and then she said are you abusing it i said nooooooo
Juicedhead
Member
is this fucking chelios? haha love that movie bro
Jin23
Well-known Member
MPH a lygand for dopamine receptors?
Btw, you can't compare two compounds simply by their general pharmacodynamics, ie. mph and coke both being dnri's. There's a lot more to it then that. From differences in brain region activity to different binding affinities as the most simple ones, ...
ChevChelios
Member
Ahah I feel ya I’ve done the same (n addys/dex are wayyy better than Ritalin) but I was just straight up about it n told people I liked how it felt, I didn’t tell a doc I was doin it for that reason but anyone else I was open about it, I doubt any doc would script him MP for that though so he might as well be straight up with the people here cos afaik his doc ain’t posting on meso (n if he is that’s one doc I’d be curious to meet, the possibilities would be endless…)
ChevChelios
Member
I ain’t comparing them n they are absolutely different but I think you could agree that using a dnri for the purpose of what OP is asking is fkin retarded ahah that doesn’t mean I’m not curious as to what the results could be but him saying he wants to use it to lower prolactin is a very messy excuse to tweak imo (as those compounds usually have certain secondary effects that could potentially even heighten his levels not lower them, not directly maybe but due to the other factors associated with the consumption of stimulants)
Juicedhead
Member
yeah exaclty. Its unlikley that ritalin would even lower prolactin as there is dopamine receptors all over the body and Im pretty sure a caber or prami is a different kind of dopamine agonist.
ChevChelios
Member
Btw I fw anyone that is a fan of chemistry, idk if that’s the case with you but it seems so. The whole point of OP’s proposed experiment is the fact that dopamine lowers prolactin levels, but he seems to have forgotten that MP is not equivalent to just dopamine, tbh he’d have a better chance with a straight up dopaminergic (not a reuptake inhibitor but a secretor) as the link between MP and prolactin is actually researched and seems to be nonexistent, imma quote a random ass study here:
Methylphenidate was not found to exhibit a consistent effect on serum prolactin. Thus, its effect on serum prolactin does not parallel its behavioral activating properties, suggesting that such activation may not involve dopamine. Possibly, norepinephrine or other noncatecholaminergic neurotransmitters are involved in methylphenidate-induced behavioral activation.
Albeit this study wasn’t specifically done with that in mind but still I’d say cabergoline would be far better suited for that specific effect, if OP wants to tweak he’s free to do so but there’s no point in him acting like it’s for another reason (although I repeat I’d very much be curious about the results regardless ahah)
