using methylphenidate instead of caber for lowering prolactin

[Jin23]

I ain’t comparing them n they are absolutely different but I think you could agree that using a dnri for the purpose of what OP is asking is fkin retarded ahah that doesn’t mean I’m not curious as to what the results could be but him saying he wants to use it to lower prolactin is a very messy excuse to tweak imo (as those compounds usually have certain secondary effects that could potentially even heighten his levels not lower them, not directly maybe but due to the other factors associated with the consumption of stimulants)

Both should lower dopamine, however, prami being a selective D3 agonist and it being more active in certain brain areas, like hypothalamus, basal ganglia, mesolimbic pathway, ... has less stimulant properties. But that's not to say it doesn't have sides related to excessive dopamin receptor activation. For some it can be pretty bad.

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[ChevChelios]

Yeah just looked it up more n we were right, at the very least he should look into a straight up agonist if he wants any effect on his prolactin, not a drni. As dopaminergic agonism is instead actually linked to such results

So yeah OP use Dexedrine or something of that sort of you wanna tweak n try to lower your prolactin levels simultaneously (although I need to look up what the serotoninergic part would do to those levels too, hmmm this thread is actually pretty fun n informative as retarded as the topic might seem ahah), definitely not MP as a first choice.

 

[Jin23]

yeah exaclty. Its unlikley that ritalin would even lower prolactin as there is dopamine receptors all over the body and Im pretty sure a caber or prami is a different kind of dopamine agonist.

MPH and coke arent dopamine receptor agonists. They are DNRI's.

 

[Jin23]

Btw I fw anyone that is a fan of chemistry, idk if that’s the case with you but it seems so. The whole point of OP’s proposed experiment is the fact that dopamine lowers prolactin levels, but he seems to have forgotten that MP is not equivalent to just dopamine, tbh he’d have a better chance with a straight up dopaminergic (not a reuptake inhibitor but a secretor) as the link between MP and prolactin is actually researched and seems to be nonexistent, imma quote a random ass study here:

Methylphenidate was not found to exhibit a consistent effect on serum prolactin. Thus, its effect on serum prolactin does not parallel its behavioral activating properties, suggesting that such activation may not involve dopamine. Possibly, norepinephrine or other noncatecholaminergic neurotransmitters are involved in methylphenidate-induced behavioral activation.

Albeit this study wasn’t specifically done with that in mind but still I’d say cabergoline would be far better suited for that specific effect, if OP wants to tweak he’s free to do so but there’s no point in him acting like it’s for another reason (although I repeat I’d very much be curious about the results regardless ahah)

Not saying mph is a good choice, just saying it will lower prolactin. Most everything which is somewhat dopaminergic will lower prolactin ...

 

[ChevChelios]

Both should lower dopamine, however, prami being a selective D3 agonist and it being more active in certain brain areas, like hypothalamus, basal ganglia, mesolimbic pathway, ... has less stimulant properties. But that's not to say it doesn't have sides related to excessive dopamin receptor activation. For some it can be pretty bad.

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Yeah I really don’t know why OP wouldn’t use something more standard or try to do some more ‘holistic’ or regardless lighter stuff first instead of jumping on a dnri for a benefit that hasn’t even been observed afaik but like I said I’m all bout experimentation so I say fk it let him tweak n figure it out, maybe some desoxyn would help as ik that is very dopaminergic ahah

 

[ChevChelios]

MPH and coke arent dopamine receptor agonists. They are DNRI's.

I think he meant that he’d be better off with an agonist at that point, at least that’s how I read his post

 

[ChevChelios]

Not saying mph is a good choice, just saying it will lower prolactin. Most everything which is somewhat dopaminergic will lower prolactin ...

No ofc, no stim drug would be ideal for that purpose. But hey still a fun thing to think bout ahah.
Either way that’s true to a certain extent (not sure how much with dnris though, straight up agonists would seem like a better bet due to direct dopaminergic stimulation instead of just reuptake inhibition).
But suppose you’re right and even that would have a mild benefit…
Wouldn’t the secondary/lifestyle effects risk heightening it more than what they possibly lower it though?

 

[Jin23]

No ofc, no stim drug would be ideal for that purpose. But hey still a fun thing to think bout ahah.
Either way that’s true to a certain extent (not sure how much with dnris though, straight up agonists would seem like a better bet due to direct dopaminergic stimulation instead of just reuptake inhibition).
But suppose you’re right and even that would have a mild benefit…
Wouldn’t the secondary/lifestyle effects risk heightening it more than what they possibly lower it though?

I'm not sure prami is a stronger D2 agonist then dopamine it self. There is nothing wrong with inhibiting dopamine reuptake which then binds to D2 receptors on lactotrophes in the pituitary. This is the normal process in fact, how prolactin is inhibited in the pituitary: dopamine gets released from hypothalamus and is transported to pituitary where it binds to D2's on lactotrophes ... I'm not well researched on prolactin inhibition though but I think dopamine has a higher binding affinity for the D2 receptor then prami.

I also can't speculate from the top of my head how much mph one would have to take in order to lower prolactin to a significant degree, however I presume it's a much lower dose then one would need to take for improving cognitive function. But again, I'm just guessing and I'm not going to research this atm.

 

[SenorSuperdrol]

Not saying mph is a good choice, just saying it will lower prolactin. Most everything which is somewhat dopaminergic will lower prolactin ...

I’ve always wondered how Modafinil affect prolactin. It would have to be to some degree I’d assume.

 

[runway]

Took 2 x 10 mg MPH per day for 3 days now, painful gyno lumps which didn't respond to adex, aromasin and dht creme are gone. Also i could nut within 2 minutes after needing at least 30 minutes on NPP. So i'm pretty sure it does lower prolactin pretty fast. If you can get over the stigma of using ritalin ... not like an ergot derivate like caber is any less nasty.

Cabergoline is a chemical of the lysergamide and ergopeptine classes. It is a close derivative of LSD, more specifically, AL-LAD, but instead shares many effects with related, non-psychedelic medicinal compounds such as ergotamine, ergonovine or lisuride. It is occasionally prescribed to treat symptoms of high prolactin levels and managing Parkinson's disease.

 

[ChevChelios]

I’ve always wondered how Modafinil affect prolactin. It would have to be to some degree I’d assume.

I would tell you personally you might as well use dex or vyvanse at that point as modafinil has some other pathways like the adrenergic ones which could be of more issue than help

 

[ChevChelios]

Took 2 x 10 mg MPH per day for 3 days now, painful gyno lumps which didn't respond to adex, aromasin and dht creme are gone. Also i could nut within 2 minutes after needing at least 30 minutes on NPP. So i'm pretty sure it does lower prolactin pretty fast. If you can get over the stigma of using ritalin ... not like an ergot derivate like caber is any less nasty.

The nutting I’d bet is more due to sex drive being elevated not the prolactin, the gyno idk tbh maybe it was something else or the MP took away some water that was under your boob or sumn but I have no idea regarding the gyno part as that makes no sense but maybe you found a cool new use for MP. But yeah the nut per I’d wager a good amount that is more due to it makin you hornier just like coke or anything else so obviously you had a better time than with NPP (which can cause some issues in that department).

Either way though I agree that caber isn’t anywhere near a ‘safe’ n clean type of thing but it’s used for a reason, but if you find relief from the MP that’s good n dude fk the stigma I was just joking n tbh imo it’s way better than lots of the other stuff we put in our bodies it just seemed kinda random as a way to lower your prolactin n imo more of an excuse to tweak ahah n there ain’t nothing wrong with that mane, but if it’s working good keep experimenting that’s a very underrated part of bbing imo, both lifting, nutrition n chemicals often were first experimented on by bodybuilders n now many of those things are commonplace even among random ass ppl so yeah dude do yo thang but yeah if the MP helped I’d say try an addy or a dexie as they would be a lot smoother n would have the same effect if the MP itself is what helped you out (it being a dnri means that an actual agonist would be even better, only one way to find out tho ahah)