V mixer for mixing capsules

[biga1987]

Is v mixer and granulator enough for mixing powders for capsules? Its ok for tablets so probably good for capsules instead of manual geometric mixing ?

 

[master.on]

Is v mixer and granulator enough for mixing powders for capsules? Its ok for tablets so probably good for capsules instead of manual geometric mixing ?

That's what pharma does
be aware that they use both geometric dilution AND mechanical mixers (they do all the geometric dilution steps in the v-mixer/blender).

Rotation speed regulation is important
Comparative study of the mixing of free-flowing particles in a V-blender and a bin-blender - ScienceDirect
so don't expect any speed will do. i.e at too high rpm the powder centrifuge force will cause powder to remain in the edges and not mix.

you must allow enough time for powders to mix
https://pdfs.semanticscholar.org/f03a/ceded9d53a731fd7c07dc8238e5568dbae2c.pdf
When in doubt it may be better to over-mix than under-mix.


Keep us posted if you find a good, yet affordable mixer
the most important part seems to be the electric motor/gearbox: is must be powerful enough to spin freely, keep rpms over a relatively narrow rpm range, yet withstand a couple hours of nonstop use.

 

[biga1987]

How much time for each round of dilution ?

 

[master.on]

How much time for each round of dilution ?

It totally depends on the filler/API and rpms.
You should Google specifics yourself

just as a mere example
Typical mixing time 5-10 minutes...
http://www.torpac.com/Reference/promixer.pdf

 

[Iron Vett]

This may be of interest for a cheap mixer for fillers and compounds.

I have a light resistor on an electronic drill and have it spinning a peanut butter jar and threw in some popsicle sticks to keep the powder moving as it spins slowly.

I personally haven't tried it yet but plan on giving it a go in the near future.

 

[master.on]

This may be of interest for a cheap mixer for fillers and compounds.



I personally haven't tried it yet but plan on giving it a go in the near future.

Just make sure it can run for half an hour nonstop without overheating
or catching fire lol.

 

[Iron Vett]

Just make sure it can run for half an hour nonstop without overheating
or catching fire lol.

Aww man. That's gonna take a lot of the excitement out if it hehe

 

[TRT]

Just make sure it can run for half an hour nonstop without overheating
or catching fire lol.

I've actually moved to using a little DC motor I bought offline with a 9v battery. Works well. I usually let it go for about an hour.
What's important is to make sure your active ingredient matches filler. A crystal like active ingredient won't mix so well with a very fine filler. You see can see it for yourself if you used a fine filler that is dark.

 

[master.on]

Check rpms if you can
V-mixers must turn quite slow
about 60 rpm
some large (industrial) mixers turn at only 45 rpm

 

[TRT]

Check rpms if you can
V-mixers must turn quite slow
about 60 rpm
some large (industrial) mixers turn at only 45 rpm

It turns pretty slow. Ya, about 60rpm. I always let it run for x amount of time. I'll set it and go out run to the bank or something. So it'll run for a few hours.
Those industrial ones move slower cause they have more powder. Get a small one set up and another one that's 2x the size and you'll see why it needs to go slower.

 

[master.on]

It turns pretty slow. Ya, about 60rpm. I always let it run for x amount of time. I'll set it and go out run to the bank or something. So it'll run for a few hours.
Those industrial ones move slower cause they have more powder. Get a small one set up and another one that's 2x the size and you'll see why it needs to go slower.

I'm glad you mentioned this
large mixers need to rotate SLOWER, since powder must gently SLIDE down the mixer walls, not just quickly fall from each side.
Since powder can only slide down so fast, larger mixers require slower speeds to compensate for the larger distance powder must slide on.

Table 6 : Scale-Up of Blending [35-39] Working Capacity (L) Typical RPM Typical Amount (Kg)
20-50 25-30 8-30
250 23-28 80-150
500 12-18 200-300
2000 8-12 800-1200
http://www.scholarsresearchlibrary....or-determination-of-v-blender-an-overview.pdf