What to add to Reta for appetite suppression? Tirz, Cagri, or something else?

[deeoeraclea]

I've been on Reta for about 4 months now. Started at 1 mg/week and slowly titrated up to my current dose of 3 mg/week. It raises my heart rate a little bit. And, it gives me some GERD. But, I haven't really experienced any appetite suppression. And, I haven't lost any weight. My LDL has gone down though. So, I'd like to stay on it. But, I'm looking to stack it with something else that gives me a bit of appetite suppression. I've heard both Tirz and Cargilintide are effective for this purpose. Any suggestion as to which is better? And, how should I dose them (considering I plan to continue using the Reta)? Open to other GLP-1s as well. But, I'm probably going to avoid Sema, as it seems to have the most undesirable side effects (e.g., nausea).

 

[tehducky599]

Fucked around with a first dose of cagri 1mg last Thursday. The fatigue is REAL. Been on Reta 2-4 mg for couple months now, nothing to do with food or calories. Fatigue-induced cagri made me go less hard in gym and sleepy as fuck, not a happy camper.

Probably should not have started at 1mg but have never encountered a compound that effected my gym performance like this. Probably a one and done with this compound.

 

[BamaCrazy]

Fucked around with a first dose of cagri 1mg last Thursday. The fatigue is REAL. Been on Reta 2-4 mg for couple months now, nothing to do with food or calories. Fatigue-induced cagri made me go less hard in gym and sleepy as fuck, not a happy camper.

Probably should not have started at 1mg but have never encountered a compound that effected my gym performance like this. Probably a one and done with this compound.

The starting dose is .25mg. Of course 1mg would make you feel awful.

 

[burner18]

I've been on reta since mid July. Started off at 2mg/week then worked my way up to 8mg/week but started experiencing GERD at that stage so I started dosing at 4mg every 3 days and that helped. Last week I started running 5mg/e3d and it's been good so far. No GERD, no nausea, etc. so it might be beneficial to change up the dose frequency first before adding another compound.

 

[sionnach]

I've been on reta since mid July. Started off at 2mg/week then worked my way up to 8mg/week but started experiencing GERD at that stage so I started dosing at 4mg every 3 days and that helped. Last week I started running 5mg/e3d and it's been good so far. No GERD, no nausea, etc. so it might be beneficial to change up the dose frequency first before adding another compound.

10/wk and you started in July? Wtf

 

[newlosand]

Very low dose Sema is the surest, and possible safest, bet, if you must stack.

I mean low dose. .25mg / week, and don't even consider increasing until after 2 weekly doses so you know what you're dealing with. It can from "this isn't enough" to "holy shit emergency room" fast if you ramp up too quickly.

 

[ChemBB]

"holy shit emergency room"

What experience(s) have you had that made you say this?

Worst I've had happen from GLP-1's is feeling sort of run-down/under the weather like I've got the flu or not slept well.

 

[Ghoul]

What experience(s) have you had that made you say this?

Worst I've had happen from GLP-1's is feeling sort of run-down/under the weather like I've got the flu or not slept well.

I went from (pharma) Sema .25 to 2.4, then migrated to (pharma) Tirz titrating to 15mg. So I'm very familiar with both these compounds at their max doses.

I tried adding .50mg Sema, a weak dose when I was originally using Sema, to the 15mg Tirz dose I had been on maintainance with for a year with no side effects, to see if I could tweak the appetite suppression up slightly.

It turned me into a toilet hugging puking / diarrhea machine.

I was convinced it was food poisoning, not the addition of this "weak" dose of Sema.

After recovering, I tried it again, and it was worse the second time, leading to rapid severe dehydration requiring a trip to the emergency room and an IV drip.

Clearly, the synergy of the two can be much greater than just adding their effects together. More like a multiplier, which is why I advise caution.

 

[ChemBB]

After recovering, I tried it again, and it was worse the second time, leading to rapid severe dehydration requiring a trip to the emergency room and an IV drip.

Clearly, the synergy of the two can be much greater than just adding their effects together. More like a multiplier, which is why I advise caution.

Wow, that's quite unfortunate -- sorry to hear you go through that.
Good to hear anecdotes like this though, not a lot of posted experiences in terms of various GLP combos.

I've had a similar thing twice when accidentally OD'ing on Phenibut.

Worst nausea + nonstop puking I've ever had in my life, for 8 hours. First time I went to the ER but there was nothing they could do except administer anti-emetics and saline IV.

Second time I just strapped myself in for the ride =/

 

[johnjay06]

Cagri scares me with the studies I read about amyloid fibrils forming, not like I really know what it means. But something to do with Alzheimer's. That shit scares the fuck out of me. I took a shot last night of 0.25 mg but had I read that earlier I wouldn't have taken it. Anyone else know anything about that?

 

[Ghoul]

Cagri scares me with the studies I read about amyloid fibrils forming, not like I really know what it means. But something to do with Alzheimer's. That shit scares the fuck out of me. I took a shot last night of 0.25 mg but had I read that earlier I wouldn't have taken it. Anyone else know anything about that?

It's ok, although cagri can form amyloid fibrils that accumulate in organs, slowly causing permanent damage, including the nervous system and potentially penetrating the blood brain barrier, there are number of very sophisticated manufacturing techniques used to prevent that from happening, along with carefully chosen excipients and precise temperature control in transport and storage:

"The careful design and formulation of cagrilintide significantly mitigate the risk of amyloid fibril formation and associated adverse effects. While formulation errors could theoretically increase this risk, stringent quality control measures in clinical settings ensure the peptide’s stability and safety"

Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors - Nature Communications

Cagrilintide is a long-acting agonist of amylin and calcitonin receptors in late phase trials for obesity. Here, authors present structures of cagilintide with each target receptor, revealing the molecular basis for its non-selective action.

www.nature.com

We're well protected by pharma manufacturers subject to "stringent quality control measures" and tight regulations.

 

[SnowyMiami]

Cagri scares me with the studies I read about amyloid fibrils forming, not like I really know what it means. But something to do with Alzheimer's. That shit scares the fuck out of me. I took a shot last night of 0.25 mg but had I read that earlier I wouldn't have taken it. Anyone else know anything about that?

It's over.

 

[deuces_00]

GLP-1 is the key "food noise" reduction molecule. Not GIP. With Sema you're only adding more food noise blunting, without needlessly adding Tirz's GIP, which is mostly responsible for non appetite suppression effects.

The GIP/Glucagon balance was key to making Reta work, when other attempts at Glucagon receptor agonist drugs failed (they caused some dangerous effects in fact).

Tirz has the native GIP sequence and works exactly like endogenous GIP, Reta very intentionally includes a GIP analogue that is much stronger. It's 9x more potent than endogenous GIP. That stronger GIP effect is needed to prevent hyperglycemia caused by Glucagon glucose release.

With both types, weak and super strong GIP in your system it's now a crapshoot which type attaches to which GIP receptor. Weak Tirz "natural" 1x GIP sitting in a receptor would block 9x strength GIP from Reta.

The GLP-1 analog in Reta is 1.4x more potent than natural, while in Sema it's 2.6x. A much closer match, and no risk of weakening the Reta GLP-1 effect, since a 2.6x strength Sema GLP-1 blocking a 1.4x Reta GLP-1 from occupying the same receptor will only increase GLP-1's effects somewhat, not weaken them.

Degree of GLP appetite suppression is hypothesized to be determined by the overall proportion of total receptors occupied (a number determined by genetics. probobly explains the wide variation in response) By adding more GLP-1 you're doing exactly that. A very targeted increase of just the molecule needed to suppress appetite, without randomly messing with other incretin hormone effects on insulin, glucose, liver metabolism etc.

The safest thing to do of course is just increase the dose of the GLP drug you're on, up to the max clinically proven safe in trials.

thank you for this response. very helpful!

 

[Here2Learn]

I’ve read a lot of research documents and testing that has been done by groups. These are my takeaways and my only real advice to you is do some research.

Do not stack Reta with anything, it is not the same as Sema and Tirz.

Do not micro dose Reta, it is not the same as Sema and Tirz. Reta is in your system 6 days and Sema and Tirz are around 4 I believe.

Follow the protocol! 2-4-6-8-12. Sure start slow to see how it goes but you increase every 4 weeks even if you are losing. Reta is not the same.

KPV is amazing for gerd or any acid/stomach issues.

People treat Reta the same as Tirz and Sema really need to spend some time looking at the data. They are very different and should be approached differently. What has happened is Sema was played around with and that same logic was applied to Tirz and it worked because they are similar. Then Reta came out and many have applied the same logic and then we see posts of “it’s not working and I don’t know why”.

 

[Deadpool99]

Fucked around with a first dose of cagri 1mg last Thursday. The fatigue is REAL. Been on Reta 2-4 mg for couple months now, nothing to do with food or calories. Fatigue-induced cagri made me go less hard in gym and sleepy as fuck, not a happy camper.

Probably should not have started at 1mg but have never encountered a compound that effected my gym performance like this. Probably a one and done with this compound.

It takes alot for me to feel full. I just dosed 0.5mg cagri added to my 15mg reta. May I ask how long it took for the first signs of cagri effects to start showing (as in getting fuller quicker)?

I know it has a long half life like reta but that shit kicks in quick, sometimes in the day of injection or the day after for me.

Theoretically it should take a while to fully build up like glp1s should (theoretically takes upto 4 for peak serum levels/steady state), but I never saw that as the case with most glp1 at least in my experience.

 

[Ateam2023]

I’ve read a lot of research documents and testing that has been done by groups. These are my takeaways and my only real advice to you is do some research.

Do not stack Reta with anything, it is not the same as Sema and Tirz.

Do not micro dose Reta, it is not the same as Sema and Tirz. Reta is in your system 6 days and Sema and Tirz are around 4 I believe.

Follow the protocol! 2-4-6-8-12. Sure start slow to see how it goes but you increase every 4 weeks even if you are losing. Reta is not the same.

KPV is amazing for gerd or any acid/stomach issues.

People treat Reta the same as Tirz and Sema really need to spend some time looking at the data. They are very different and should be approached differently. What has happened is Sema was played around with and that same logic was applied to Tirz and it worked because they are similar. Then Reta came out and many have applied the same logic and then we see posts of “it’s not working and I don’t know why”.

im having great results so far micro dosing Reta, im not trying to lose weight per say, just better bg numbers and any other "blood marker improvements" that Reta can help, I am in week 2 of Reta and my fbg was 85 yesterday and i havent had a fbg reading that low EVER, starting dose was .5 mg week 1, now week 2 i am splitting the dose .25mg on Monday and Thursday, so far so good on Micro dosing Retatrutide. ymmv

 

[Here2Learn]

im having great results so far micro dosing Reta, im not trying to lose weight per say, just better bg numbers and any other "blood marker improvements" that Reta can help, I am in week 2 of Reta and my fbg was 85 yesterday and i havent had a fbg reading that low EVER, starting dose was .5 mg week 1, now week 2 i am splitting the dose .25mg on Monday and Thursday, so far so good on Micro dosing Retatrutide. ymmv

What you’re doing is actually true microdosing, since your total weekly amount is still below the usual starting dose. Even with Reta’s long half-life, your levels won’t build up very high.

A lot of people use the term ‘microdosing’ when they’re just splitting a regular weekly dose into smaller shots. With sema or tirz (half-life ~4–5 days), that approach smooths out peaks and side effects, but overall exposure stays about the same. Probably could make the case the proper way to dose would be every 4 days.

With Reta, it’s different (half-life is ~6–7 days), so each piece of a split dose overlaps more and stacks higher. That means splitting doesn’t actually lower the effective dose; it raises the dose due to 60-70% of the previous dose still being in the system. The key difference is that you’re both splitting and keeping the total weekly dose very low, which is why your approach really is microdosing.

 

[tehducky599]

It takes alot for me to feel full. I just dosed 0.5mg cagri added to my 15mg reta. May I ask how long it took for the first signs of cagri effects to start showing (as in getting fuller quicker)?

I know it has a long half life like reta but that shit kicks in quick, sometimes in the day of injection or the day after for me.

Theoretically it should take a while to fully build up like glp1s should (theoretically takes upto 4 for peak serum levels/steady state), but I never saw that as the case with most glp1 at least in my experience.

It was quite fast for me, I felt it on the day after pin. Probably peaking end of that day and day after, so days 2-3.