Who has been including a PDE5i for ASIH/PCT?
FWIW: I am now routinely including their use.
FWIW: I am now routinely including their use.
MESO-Rx
Anabolic Steroids
Who has been including a PDE5i for ASIH/PCT?
- Thread starter Michael Scally MD
- Start date
I use ~5mg Tadalafil before my workouts so basically EOD. Whether on cycle, off, or on PCT. My lady and I both have no complaints.
Jimmyinkedup
New Member
I have incorporated a low dose daily cialis protocol i run continuously. I like the BP effects, no BPH issues on cycle which I previously would experience, and of course the added well known benefits of a pde5i. So while not strictly a part of my pct something I am glad I have incorporated.
Chronic, Long-Term Administration of Vardenafil Improves Endothelial Function and CORRECTS HYPOGONADISM in Patients with Type 2 Diabetes Mellitus. A Longitudinal, Prospective, Randomized, Placebo-Controlled, Double Blind, Clinical Trial.
http://www.endocrine-abstracts.org/ea/0037/ea0037oc4.3.htm
Background: Endothelial dysfunction leads to cardiovascular complications in type 2 diabetes mellitus (T2DM), through a reduction of nitric oxide (NO)-mediated relaxation. Phosphodiesterase-5 inhibitors (PDE5i) have hemodynamic effects, improving NO levels.
Aim: To investigate if long term, chronic treatment with the PDE5i Vardenafil improves systemic endothelial function in men with T2DM.
Methods: A longitudinal, prospective, investigator-started, randomized, placebo-controlled, double-blind, clinical-trial was carried out. 54 male patients affected by T2DM diagnosed within the last 5 years were enrolled. 26 and 28 patients were assigned by permuted block randomization to the verum and placebo-group, respectively. The study consisted of an enrollment phase, a treatment phase (24 weeks) (Vardenafil/placebo 10 mg twice-daily), and a follow-up phase (24 weeks). Parameters evaluated: International Index of Erectile Function (IIEF)-15, flow mediated dilation (FMD), intima media thickness (IMT), routine hematologic analyses. Serum testosterone (T) and its precursors were measured by liquid-chromatography tandem mass-spectrometry (LC-MS/MS). Gonadotropins were evaluated by ELISA.
Results: Only one serious adverse event was registered in the placebo group. The erectile function domain of IIEF-15 (P=0.049) improved after treatment. At the end of the treatment phase FMD significantly increased (P=0.002) while IMT (P=0.003), fibrinogen (P=0.005), white blood cells count (P=0.018) and Red cells Distribution Width (P=0.028) significantly decreased. FMD was significantly related to T serum levels (P=0.002), which significantly improved after Vardenafil treatment only in hypogonadal men (T<10.4 nmol/l) (P=0.023), without changes in gonadotropin serum levels. Smoking-habits, hypertension and glycemic control influenced the hemodynamic and inflammatory parameters.
Conclusions: This is the first double-blind, placebo-controlled clinical-trial in which T2DM men are chronically treated with Vardenafil for 6 months, and followed-up for 6 months after therapy-withdrawal. Chronically administered Vardenafil is safe and effective in T2DM patients and improves both tissue oxygenation and inflammatory markers, but this effect is lost after therapy withdrawal. For the first time, we demonstrate that chronic Vardenafil therapy improves T (measured by LC-MS/MS) in diabetic, hypogonadal men, an effect possibly due to improved microcirculation in the testis (EudraCT number 2009-014137-25).
http://www.endocrine-abstracts.org/ea/0037/ea0037oc4.3.htm
Background: Endothelial dysfunction leads to cardiovascular complications in type 2 diabetes mellitus (T2DM), through a reduction of nitric oxide (NO)-mediated relaxation. Phosphodiesterase-5 inhibitors (PDE5i) have hemodynamic effects, improving NO levels.
Aim: To investigate if long term, chronic treatment with the PDE5i Vardenafil improves systemic endothelial function in men with T2DM.
Methods: A longitudinal, prospective, investigator-started, randomized, placebo-controlled, double-blind, clinical-trial was carried out. 54 male patients affected by T2DM diagnosed within the last 5 years were enrolled. 26 and 28 patients were assigned by permuted block randomization to the verum and placebo-group, respectively. The study consisted of an enrollment phase, a treatment phase (24 weeks) (Vardenafil/placebo 10 mg twice-daily), and a follow-up phase (24 weeks). Parameters evaluated: International Index of Erectile Function (IIEF)-15, flow mediated dilation (FMD), intima media thickness (IMT), routine hematologic analyses. Serum testosterone (T) and its precursors were measured by liquid-chromatography tandem mass-spectrometry (LC-MS/MS). Gonadotropins were evaluated by ELISA.
Results: Only one serious adverse event was registered in the placebo group. The erectile function domain of IIEF-15 (P=0.049) improved after treatment. At the end of the treatment phase FMD significantly increased (P=0.002) while IMT (P=0.003), fibrinogen (P=0.005), white blood cells count (P=0.018) and Red cells Distribution Width (P=0.028) significantly decreased. FMD was significantly related to T serum levels (P=0.002), which significantly improved after Vardenafil treatment only in hypogonadal men (T<10.4 nmol/l) (P=0.023), without changes in gonadotropin serum levels. Smoking-habits, hypertension and glycemic control influenced the hemodynamic and inflammatory parameters.
Conclusions: This is the first double-blind, placebo-controlled clinical-trial in which T2DM men are chronically treated with Vardenafil for 6 months, and followed-up for 6 months after therapy-withdrawal. Chronically administered Vardenafil is safe and effective in T2DM patients and improves both tissue oxygenation and inflammatory markers, but this effect is lost after therapy withdrawal. For the first time, we demonstrate that chronic Vardenafil therapy improves T (measured by LC-MS/MS) in diabetic, hypogonadal men, an effect possibly due to improved microcirculation in the testis (EudraCT number 2009-014137-25).
Volley_Fire
New Member
Thinking that I'll add some Icariin/Horny Goat Weed to my PCT now.
I take 5mg cialis ED.
But I stop for one week or two here and there just so I can keep feeling it.
It's a bit expensive but worth it in my opinion. Do you all use pharma grade cialis? Or some
Ugl?
But I stop for one week or two here and there just so I can keep feeling it.
It's a bit expensive but worth it in my opinion. Do you all use pharma grade cialis? Or some
Ugl?
Jimmyinkedup
New Member
I use RC cia from a company I have had good success with and have for some time. I actually dropped my daily dose to 3mg because at 5mg after about 2 weeks I was a walking hard on. It was nice using a liquid and easily being able to adjust my dose. Im on my second bottle of cia and happy to say my dose stayed the same, so at least their product is not only legit but consistent.
Northern Nutrition
Subscriber
I had the exact opposite results from the same company with two different orders. Too bad too because i agree, liquid is so easy to dose compared to splitting small pills. Although i now have a line on 5mg Cialis pharm tabs that i use daily.
Any long term side effect known?
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