Sicsemptyran
New Member
The horrifying thing was not referring to the statin piece, not at all saying it’s horrifying for a doctor to say to go from 10 -> 20mg of a statin haha!
MESO-Rx
Anabolic Steroids
Who here is on a statin?
- Thread starter Juicedhead
- Start date
I just received my CT CAC Scan results 1 hour ago. My Total Calcium Score is 0 with a percentile ranking of 0-25%. And my regional non-cardiac anatomy is normal. My Doc says I’m the first person he’s seen over 50 receive a score of 0.
Heart disease is hereditary in the men in my family so I am pretty happy about the results. I’ve been on Rosuvastatin for several years so it must be helping.
I also had bloodwork this morning and included Lp(a) and apolipoprotein B (apoB) this time. Hopefully those results are also positive.
Heart disease is hereditary in the men in my family so I am pretty happy about the results. I’ve been on Rosuvastatin for several years so it must be helping.
I also had bloodwork this morning and included Lp(a) and apolipoprotein B (apoB) this time. Hopefully those results are also positive.
Most people who use an ARB are also on a beta blocker? That’s interesting. I’d love to see your source for this so I can learn more.
Mature as fuck post right here. Respect
egruberman
Well-known Member
Hell yes. Congratulations on winning the genetic lottery.
That said, might be worthwhile to test again in a few years to back up the result.
egruberman
Well-known Member
10-20mg isn't "horrifying" per se, but it's pushing the dose further down the flat line of the dose response curve which leads to a greater likelihood of adverse side effects. Myalgia, tendon issues, insulin resistance all occur at higher doses. A max dose of Atorvastatin generally yields type 2 diabetes in 1/3 of patients after a few years, a fact which then causes me to wonder why in the fuck anyone would want to push statin monotherapy to the max dose.
Rosuvastatin and Atorvastatin are fundamentally different in how they are metabolized. Yes, they are used interchangeably, but that doesn't mean they are the same. Rosuvastatin is more potent on a per milligram basis. Is hydrophilic, doesn't cross the blood/brain barrier, nor tax the liver quite the same as Atorvastatin.
I personally believe it's just inertia. The clinical trials (from a couple decades back) all used very high doses to guarantee a positive response in a population that was at very high risk for whom anything other than the max dose would have been unethical. Which has led me to the conclusion that the medical community is really focused on treating MACE rather than the disease itself. As though it's inevitable that you're going to have a heart attack, but once you do, they'll treat you.
I want to thank you for your feedback, knowledge and insight. For every 5 trolls, and 10+ members using this forum purely as a marketplace, there are many more of us here learning valuable health information, advice, and real life experiences that could make a difference in future outcomes.
Anonymous35
New Member
I don’t lied to myself lmao it exactly what i have said doctor in pharmacy for pharmacist
And degree bachelor to work at hospital which is true
With only the deust you can’t work at the hospital buddy or maybe you can but they will forced you to do the degree
And no we have the same responsabilities, at the exception if they own a pharmacy which is different
If i did a mistake i can get fired to the same extent as a pharmacist simple as that
Anonymous35
New Member
Especially vitamine D is cheap and nearly everybody lack of it
…
Anonymous35
New Member
I agree i’ve seen strong dose a statin a lot
80 mg of atorvastatin
This is a lot
But yeah 10/20 of atorvastatin is moderate
If you want the equivalent dose is this
5mg rosu= 10 mg atorvastatin
20mg simvastatin = 10mg atorvastatin
10mg simvastatin = 20mg pravastatin
So as you can see the strongest is rosuvasatatin and the safest is pravastatin
Anonymous35
New Member
From the prescription that i have when i worked at the hospital that i see daily
Oddly enough she just offered me choices after my month 2 bloods on 10mg Lipitor came back w/LDL of 102 which is still too high. She said I can go to 20mg Lipitor (her advice), add Zetia or add "an injectable that my insurance most like won't cover unless we try the higher dose statin or combo therapy first" which I'm assuming is Repatha. I called and it does need prior authorization. Anyone have success with the copay card on their site? What did you pay? Although I'd imagine having a calcium score in the 95th percentile in early 40s may make help with prior authorization.
Of course you're going to see a lot of patients in a hospital setting, especially heart disease patients, post cath lab patients, that are on both drugs because they're obviously not healthy being in the hospital so much more likely to be on both. This isn't representative of the general population though. I'd say maybe 25% of people on an ARB like Telmisartan are also on a beta blocker.
egruberman
Well-known Member
Goddamn, get on a PCSK9i ASAP.
Copay card is easy peasy. There are no income limitations or anything that I'm aware of. I applied, got it, and discovered that I didn't need it when I went to use it.
As it turns out, my employer has a rider on the pharmacy benefit for "preventative" meds that include both Repatha and bempedoic acid without need for prior auth.
So, do this. Get the copay card and the Rx and get it filled. There's no reason you can't add in the Zetia anyway, so do that too. Even better if you can get Nexlizet. I'd switch to Crestor at some point for greater efficacy, but do that when you're not changing anything else. Some people experience sides with one or the other.
Look at it like this. You're in the process of dying from this disease. The calcium score is proof of that. No matter what else you do, the lower you can get your ApoB, the longer you will go without a MACE.
Cool thing about a myocardial infarction is that the most common presentation is easy to spot. You'll be dead 1/3 of the time. The other 2/3 of the time you're guaranteed a life of exciting new medical interventions.
Anonymous35
New Member
Probably more in france because betablocker are used a lot here
Its the most prescibed drug with atorvastatin here
(Bisoprolol)
I think I might have made a mistake with my labs but I learned something from it.
Yesterday I went in for extensive lab work. Fitomics had a sale late last year so I bought several panels checking liver, kidney, heart, blood, lipids, Hgb A1c, etc. My job also pays me to check lipids and biometrics annually so I took their form also. Lipid results returned this morning.
The results are interesting. Fasting glucose is within range. Triglycerides and LDL are great. HDL increased from 33 to 37 which is still low but better. But total cholesterol dropped from 133 to 95. Apparently your total cholesterol can be too low but the experts are unsure what the consequences could be from LDL or total cholesterol being too low.
For reference I take 10mg Crestor and 10mg Zetia daily. I added Zetia 3-4 weeks ago to see if my HDL would increase.
Where I might have made a mistake is Sunday I completed a 7 day cycle of doxycycline, then had labs on Wednesday.
I looked up the impacts of antibiotics on lab work and this is what I learned.
1. Impacts to white blood cell count which was to be expected but I don’t have those results back yet.
2. Some antibiotics can reduce RBC.
3. Because many antibiotics are metabolized in the liver the liver function test, ALT and AST could be elevated.
4. Some antibiotics are hard on the kidney causing BUN and creatinine to be elevated.
5. I found a study that found that Doxycycline reduced liver cholesterol, increasing HDL but lowering total cholesterol. Also, “Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products.”
I might redo some of these labs in a few weeks. Most guidance I found was you should wait a few days after completing your antibiotics before getting lab work but didn’t state exactly how many days.
Here is an article discussing the impacts of doxycycline on cholesterol levels.
www.nature.com
Yesterday I went in for extensive lab work. Fitomics had a sale late last year so I bought several panels checking liver, kidney, heart, blood, lipids, Hgb A1c, etc. My job also pays me to check lipids and biometrics annually so I took their form also. Lipid results returned this morning.
The results are interesting. Fasting glucose is within range. Triglycerides and LDL are great. HDL increased from 33 to 37 which is still low but better. But total cholesterol dropped from 133 to 95. Apparently your total cholesterol can be too low but the experts are unsure what the consequences could be from LDL or total cholesterol being too low.
For reference I take 10mg Crestor and 10mg Zetia daily. I added Zetia 3-4 weeks ago to see if my HDL would increase.
Where I might have made a mistake is Sunday I completed a 7 day cycle of doxycycline, then had labs on Wednesday.
I looked up the impacts of antibiotics on lab work and this is what I learned.
1. Impacts to white blood cell count which was to be expected but I don’t have those results back yet.
2. Some antibiotics can reduce RBC.
3. Because many antibiotics are metabolized in the liver the liver function test, ALT and AST could be elevated.
4. Some antibiotics are hard on the kidney causing BUN and creatinine to be elevated.
5. I found a study that found that Doxycycline reduced liver cholesterol, increasing HDL but lowering total cholesterol. Also, “Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products.”
I might redo some of these labs in a few weeks. Most guidance I found was you should wait a few days after completing your antibiotics before getting lab work but didn’t state exactly how many days.
Here is an article discussing the impacts of doxycycline on cholesterol levels.
Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice - Scientific Reports
The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal...
www.nature.com
I had total cholesterol in the 70 as well .. can't find any studies or information if having it too low can be a bad thing or not. Everything online is on high cholesterol never on too low cholesterol.I think I might have made a mistake with my labs but I learned something from it.
Yesterday I went in for extensive lab work. Fitomics had a sale late last year so I bought several panels checking liver, kidney, heart, blood, lipids, Hgb A1c, etc. My job also pays me to check lipids and biometrics annually so I took their form also. Lipid results returned this morning.
The results are interesting. Fasting glucose is within range. Triglycerides and LDL are great. HDL increased from 33 to 37 which is still low but better. But total cholesterol dropped from 133 to 95. Apparently your total cholesterol can be too low but the experts are unsure what the consequences could be from LDL or total cholesterol being too low.
For reference I take 10mg Crestor and 10mg Zetia daily. I added Zetia 3-4 weeks ago to see if my HDL would increase.
Where I might have made a mistake is Sunday I completed a 7 day cycle of doxycycline, then had labs on Wednesday.
I looked up the impacts of antibiotics on lab work and this is what I learned.
1. Impacts to white blood cell count which was to be expected but I don’t have those results back yet.
2. Some antibiotics can reduce RBC.
3. Because many antibiotics are metabolized in the liver the liver function test, ALT and AST could be elevated.
4. Some antibiotics are hard on the kidney causing BUN and creatinine to be elevated.
5. I found a study that found that Doxycycline reduced liver cholesterol, increasing HDL but lowering total cholesterol. Also, “Glucose and insulin tolerances were improved, accompanying with reduced fasting blood glucose, insulin, HOMA-IR and advanced glycation end products.”
I might redo some of these labs in a few weeks. Most guidance I found was you should wait a few days after completing your antibiotics before getting lab work but didn’t state exactly how many days.
Here is an article discussing the impacts of doxycycline on cholesterol levels.
Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice - Scientific Reports
The aim of this study was to determine whether low dose doxycycline as an anti-inflammatory agent could improve glucose metabolism in diabetic animals. Therefore, doxycycline was supplemented in drinking water to 6-week-old male db/db mice for 10 weeks. Doxycycline reduced perirenal/epididymal...
I said fuck it and went on with my life. Always had a very low total cholesterol and that's why my LDL is super low as well. Of course you can't have a high HDL etc if your total cholesterol is 70-80 xD
these are some amazing results , thanks for sharing.Added rosuvastatin 2.5mg daily for over a month
Those are the results.
(No additional supplements were used)
Test e 150mg a week
Dhea 25mg a day
Pregnenalone 10mg a day
(Please see dates)
can you share what your HDL value was at that low total level ?
Gotta recheck but it was 37 or 35 if I'm not mistaken
