MESO-Rx

Anabolic Steroids

Who here is on a statin?

Highlights Only
There's a lot of misinformation being carried over that is actually tied to ancient statins, but rosuvastatin is the current gold standard in the US and has no side effects for the vast majority of people.

It's extremely potent and doesn't cause hair loss.
Previously, my LDL/HDL were at the higher limits but within range, though my triglycerides were a bit high. In August 2024, I ended up having to get 4 stents in my heart, which was a surprise to everyone including the cardiologist because I was really fit and there were zero indicators on the EKG, stress test or calcium score. My only symptom was fatigue.

I've been on 20mg rosuvastatin since then, really just as a preventative and my HDL, LDL, and triglycerides are all now at the very bottom of the range with no change to macros or diet.
 
LoremIpsum9921 said:
I used for one year rosuvastatin with a very low dose of 2-3 mg (I just split the tablets) to bring my 40-50 mg/dL LDL down to 20-30 mg/dL. I did combine it with 5 mg Ezetimibe, Citrus Bergamot, fish oil, nattokinase etc. Everything else was and still is on point. I take, all year around nebivolol 5mg and telmisartan 80 mg.

But half a year ago, I got rhabdomyolysis (CPK of 40k+) from a vigorous 4 hour workout on ritalin (which also increases the risk of rhabdo) and spent some time in the hospital with an acute kidney injury. I don't wish anyone to experience this. When this happened, I was on 2.5 mg rosuvastatin.

Luckily my eGFR is back to baseline (120+, cystatin-c of 0.72) and it seems like I got no lasting kidney damage. During this time I also used empagliflozine 6 mg (I also split the tablets and my urine stick shows glycosuria) and was off steroids for almost a year.

Before this incident I got my CPK a couple of times up to 1k from exercise (normally I train to failure with additional all to failure dropsets) without being on a statin. I never had any symptoms, not even DOMS.

Now I'm scared to take a (low dose) statin anymore, I know that rhabdomyolysis is undoubtedly a contraindication for statin use, and we know that statins carry the risk to develop rhabdo without even being physically active. I don't want to risk my kidneys, a destroyed nephron will stay destroyed for the rest of the life.

That's annoying because I really want to do steroids again since my last cycle was more than a year ago and I would love to implement anavar in my next cycle, but I don't want to fuck with my lipids.
Before ezetimibe and rosuvastatin my LDL was 82 mg/dL and HDL 60 mg/dl on just 500 mg of test.
I know this is a value many people dream of, even off cycle and on medication.

Any suggestion? Just skip all statins? Try pita instead of rosuva? bempedoic acid? Be happy with my numbers and just don't think about 70+ mg/dL LDL?
Click to expand...
I'll just be the one to say that the statin didn't contribute to your rhabdo in any meaningful way. The incidence of rhabdo on 3mg of rosuva would be nearly 0.

CVD risk continues to drop the lower you get your LDL. Ezetimibe is one of the safest cholesterol medications you can take, so I would use that no matter what.

Also, you shouldn't split empagliflozin tablets
 
rxzed said:
I'll just be the one to say that the statin didn't contribute to your rhabdo in any meaningful way. The incidence of rhabdo on 3mg of rosuva would be nearly 0.

CVD risk continues to drop the lower you get your LDL. Ezetimibe is one of the safest cholesterol medications you can take, so I would use that no matter what.

Also, you shouldn't split empagliflozin tablets
Click to expand...
I guess you're right, it was also probably not statin related and just stupid overtraining.
The drop for CVD is also the reason I want to crush my LDL / ApoB, hsCRP, and HbA1c.

I read quite often that empagliflozin should not be split (it's also in the package leaflet), but I measured with urine sticks my glucose output for various dosages over a couple of days, and it's still very well detectable on 6-7 mg (1/4 of a 25 mg tablet).
My glucose baseline is already on the lower side with 60-70 mg / dL (my insulin is also based on the reference range too low; thus I'm quite insulin sensitive) and I would rather not get an atypical ketoacidosis or hypoglycaemic episodes. It's also way cheaper this way, since a package costs me 50 euros in europe. The reason for the sglt2 inhibitor is mainly kidney protection.
 
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