betterthanu
New Member
DOES IT HAVE TO DO WITH STOMACH ACIDS??? jUST WONDERING WHY DBOL AND OTHERS ARE ORAL? LET ME KNOW.
MESO-Rx
Anabolic Steroids
Why Can't Test Be In Pill Form?
- Thread starter betterthanu
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pumppumppuk
New Member
andriol and methyltestosterone
PPP
PPP
pumppumppuk
New Member
i dont think andriol is hard on the liver, but methyltestosterone is very hard on the liver.
PPP
PPP
ronnievanzant
New Member
Straight up testosterone is not "orally active" as they say because the liver metabolizes most of the testosterone on the hepatic first pass before the drug ever reaches the blood stream. This is why oral steroids have a 17 alpha alkyl group that allows them to withstand the hepatic first pass. Methyltestosterone is essentially orally active testosterone, but why use it when you can inject and save your liver?
-RVZ
-RVZ
lonewolf36
New Member
Besides, most of us like the feel of pinz so much, if it only came in pills we'd just crush up the pills, cook it in some suspension and shoot it anyway.
betterthanu said:
It doesn't have anything to do with stomach acids. It has everything to do with the deactivation of the drug by the liver.
If the steroid molecule injested orally is not protected in some way, the liver breaks down the molecule and the steroid is then unable to exert its effects. The most common way to protect the molecule is by a process known as 17 alpha alkylation. Which basically eliminates the liver's primary means of deactivating the molecule. Most injectable steroids don't have this protection and therefore are not effective when taken orally.
However, it wouldn't be correct to say they are zero percent effective, as when injested orally, a steroid such as Testosterone would have approximately +/- 3% survive the first pass through the liver. It hardly seems worth it until you realize the prescription oral testosterone, Andriol (testosterone undecanoate), only has about +/- 6% survival rate on the first pass. But that's not saying much and Andriol is generally considered ineffective as a steroid for bodybuilders. But if you want to give your little old grandma a little more spring in her step, tell her they're vitamins and watch her go!
MaxRep
thefallguy
New Member
MaxRep said:It doesn't have anything to do with stomach acids. It has everything to do with the deactivation of the drug by the liver.
If the steroid molecule injested orally is not protected in some way, the liver breaks down the molecule and the steroid is then unable to exert its effects. The most common way to protect the molecule is by a process known as 17 alpha alkylation. Which basically eliminates the liver's primary means of deactivating the molecule. Most injectable steroids don't have this protection and therefore are not effective when taken orally.
However, it wouldn't be correct to say they are zero percent effective, as when injested orally, a steroid such as Testosterone would have approximately +/- 3% survive the first pass through the liver. It hardly seems worth it until you realize the prescription oral testosterone, Andriol (testosterone undecanoate), only has about +/- 6% survival rate on the first pass. But that's not saying much and Andriol is generally considered ineffective as a steroid for bodybuilders. But if you want to give your little old grandma a little more spring in her step, tell her they're vitamins and watch her go!
MaxRep
Andriol can be some what effective if you take 600mg daily, but this will be cost prohibitive for most. They may come out with a high dosed cap with a more effective deliverly method in the near future....well there working on it. It would be great for life extension purposes.
Endocrine_Supply
New Member
You can wrap a cyclo around the test molecule... and have it absorb through the mucus lining.
Its semi effective... better that andriol Id say. -ES
Its semi effective... better that andriol Id say. -ES
yeah ive done that, i bought some cyclodextrin from kilosports, then used fina powder and water, cyclodextrin made fina water soluble, but i had to put so much of cyclodextrin to do taht, anyways, it worked okay, DMSO method would be better and fina kit and shooting it is definitely the best.
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