"Ask Chest Rockwell" column - Open thread for member questions

[ChestRockwell]

@Wunderpus Let's move this over to the Q/A thread for the actual article.

Here you go: https://thinksteroids.com/community...h-hormone-protocol-for-hypertrophy.134389945/

Can you copy/paste it over there for me pretty please?

 

[Xlgx]

One more for you CR. Previously I enquired about doing 2iu hgh eod for general health and longevity with perhaps some minor fat loss etc. do you think these results could be further optimized if on the non hgh days mk677 was added?

 

[ChestRockwell]

One more for you CR. Previously I enquired about doing 2iu hgh eod for general health and longevity with perhaps some minor fat loss etc. do you think these results could be further optimized if on the non hgh days mk677 was added?

If an individual is concerned primarily with general health and wellness (won't go so far as to say longevity), I'd be more in favor of a true HRT program that includes ED injections of rHGH.

Although trials have experimented with MK677 as a potential treatment option, I am still not a huge fan. Anecdotally, I've found that it has a tendency to significantly alter blood glucose patterns, and does so very quickly. It just seems to have a higher incident rate of side-effects overall, as compared to rHGH. This is not something that is necessarily seen in trials, so I speculate most folks are resorting to peptide companies that probably aren't providing quality product.

 

[master.on]

Can @ChestRockwell try to devise a " use X mg of Y AI for every Z dose of T" protocol in a SCIENTIFIC way?

something like Googleing the Aromatase enzyme concentration (in blood) and AI binding-affinities or efficiency figures?
Probably easier for "suicide" AIs as they seem to only stop 1 Aromatase molecule for every AI molecule
(Google Aromatase enzyme and AI molecular weights, I'm glad to help with the math if requested)

That'd make a great @ChestRockwell article.

 

[ChestRockwell]

That'd make a great @ChestRockwell article.

Certainly intriguing, but the problem with these topics would be to create a usable "one size fits all" formula. Unfortunately, there are just so many individual variances that this would be improbable to come up with...

 

[master.on]

Can @ChestRockwell try to devise a " use X mg of Y AI for every Z dose of T" protocol in a SCIENTIFIC way?

something like Googleing the Aromatase enzyme concentration (in blood) and AI binding-affinities or efficiency figures?
Probably easier for "suicide" AIs as they seem to only stop 1 Aromatase molecule for every AI molecule
(Google Aromatase enzyme and AI molecular weights, I'm glad to help with the math if requested)

That'd make a great @ChestRockwell article.

Certainly intriguing, but the problem with these topics would be to create a usable "one size fits all" formula. Unfortunately, there are just so many individual variances that this would be improbable to come up with...

Agree
but research may prove interesting.

Gonadotropins increase Aromatase
this may well explain excess estro with hcg use, but also hinders recovery because LH/FSH, besides increasing natural T, also increase T to E conversion
This may well make room for tiny dose AIs for PCT
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism. - PubMed - NCBI

Also aromatase is decreased by increased prolactin
Factors known to increase aromatase activity include age, obesity, insulin, gonadotropins, and alcohol. Aromatase activity is decreased by prolactin, anti-Müllerian hormone and the common herbicide glyphosate
Aromatase - Wikipedia
This is totally counterintuitive and unexpected

Cortisol increases aromatase (at least in vitro)
Aromatization of steroids in peripheral tissues. - PubMed - NCBI
(yet another reason for small, frequent meals?)

and this one suggests hcg and prolactin don't increase aromatase
(again in vitro which may be different than in vivo)
Factors affecting the conversion of androstenedione to estrogens by human fetal hepatocytes in monolayer culture. - PubMed - NCBI

DHT (undecanoate) decreases Prolactin
Prolactin secretion in the human male is increased by endogenous oestrogens and decreased by exogenous/endogenous androgens. - PubMed - NCBI
So you see serendipity rewarded us

Maybe Androsterone holds promise as the new, legal super-Proviron?

was shown that estrogen formation was stimulated by cortisol (10(-6) M) and inhibited by endogenous 5 alpha-reduced androgens: 5 alpha-androstene-dione greater than androsterone greater than dihydrotestosterone greater than epiandrosterone greater than 3 alpha- and 3 beta- androstanediol. It was also shown that 19-nortestosterone and 19-norandrostenedione (10(-6) M) inhibited E1 formation by 80%.
Aromatase activity in the breast and other peripheral tissues and its therapeutic regulation. - PubMed - NCBI
So 19-nortestosterone (Nandrolone) inhibits aromatase too?
Again, unexpected and counterintuitive.

 

[ChestRockwell]

@master.on For what it is worth, I do plan on a comprehensive A:E ratio based article at some point in the future.

This should cover some of the ground you are discussing, I think.

 

[master.on]

@master.on For what it is worth, I do plan on a comprehensive A:E ratio based article at some point in the future.

This should cover some of the ground you are discussing, I think.

Great

Be prepared for serendipity as you read the studies.