HGH vs IGF-1

[Deadp007]

I think it was a joke

 

[Daddymcd]

What was your protocol?
What version of IGF-1 (LR3 or DES)?

Nah, wasn't joking. I forget exact mgs and mcgs but I'd take the cjc and ipamorelin around 5 AM preworkout combined with IGF-1 and HGH frag.

For my second mid-day workout, I'd take sermorlein, ghrp2, and ghrp6 minutes before hitting the weights.

I'd usually run 4-6 IU at bedtime unless the edema in my feet/ankles got too bad and then I'd drop down to 2IU.

Hard to compare results, I'd throw in random 5 day cycles of mk677 in there when my appetite was slowing down.

I liked igf-1 more than any other peptide I've tried. I put on some crazy size compared to just HGH. I'd recommend stacking it with cjc and ipamorelin, or sermorlein.

 

[Deadp007]

Nah, wasn't joking. I forget exact mgs and mcgs but I'd take the cjc and ipamorelin around 5 AM preworkout combined with IGF-1 and HGH frag.
...
I liked igf-1 more than any other peptide I've tried. I put on some crazy size compared to just HGH. I'd recommend stacking it with cjc and ipamorelin, or sermorlein.

What version of IGF-1?

 

[Daddymcd]

What version of IGF-1?

From peptide sciences, IGF LR3, wasn't a fan of the DES

 

[Csshotty]

Although this question was not addressed to me, I'll provide my thoughts (for whatever they're worth).

The short answer is: you're on the right track.

I like berberine with hGH a lot. Metformin, functionally, is similar... However, it seems to lead to GI-related issues for many users. This leads to issues eating, which, largely leaves a lot of progress on the table... Can't eat, can't grow.

I've taken IGF-1 LR3, Increlex, various generic hGH and pharma hGH over the years... The results from Increlex were the best (in terms of muscle gained), but, I also carried a lot of water and honestly the cost was too limiting to justify.

Your best bet would be quality hGH and berberine..

Then, MAYBE IGF-1 LR3 solely for its insulin sensitizing effects (if needed) if you want to really blast hGH (6iu+ daily) for a period...

How are you dosing your Berberine and GH?

 

[Csshotty]

GH is lipolytic, whereas IGF-I opposes this effect somewhat (e.g., rhGH can stimulate local lipoatrophy vs. rhIGF-I local lipohypertrophy). GH & IGF-I act in a complementary fashion in many biological effects, e.g., the hyperglycemic effect of GH is opposed by the hypoglycemic effect of IGF-I, resulting in a middling-out of behavior. But IGF-I does enhance insulin sensitivity & fatty acid, glucose metabolism, thereby indirectly enhancing fat loss.

The primary reason that healthy adults generally use rhGH rather than rhIGF-I is because rhGH stimulates the complementary functions of GH/IGF-I, that in turn stimulate growth & metabolism. RhIGF-I (e.g., Increlex) is indicated for one very small clinical population, severe primary IGF-I deficiency; that is usually comorbid with absolute resistance to GH (such that rhGH cannot stimulate liver-secreted IGF-I).

Neither rhIGF-I nor rhGH have been shown to increase morbidity in long-term analyses of clinical populations due to neoplasms or cancers. While the two drugs can logically worsen prognosis of certain active neoplasms because of their mitogenic and proliferative effects, they have not been shown to initiate mutagenesis.

Isn’t the point of taking hgh the secretion of igf-1? Why would the effects then differ beyond pure half-life?

 

[samuelclemens95]

From peptide sciences, IGF LR3, wasn't a fan of the DES

Did you use the receptor grade or media grade? And were the gains permanent? When I used LR3 before I noticed my abs leaning out overnight but it seemed like a purely cosmetic effect that dissipated as soon as I got off. Any strength gains?

 

[Type-IIx]

Isn’t the point of taking hgh the secretion of igf-1? Why would the effects then differ beyond pure half-life?

It would seem you are attempting to grossly oversimplify the rational use of rhGH.

While I believe that the primary (but not sole) rationale of rhGH for bodybuilding is to increase IGF-I (and insulin), the markedly different pharmacokinetics & pharmacodynamics, not the least of which include different profiles of binding to the binary & ternary complexes, free IGF-I, etc. but also, half-life, that is not so tritely dismissed in its practical importance given the differences in affordability and availability of rhIGF-I (e.g., Increlex) vs. rhGH.

 

[Deadp007]

Did you use the receptor grade or media grade? And were the gains permanent? When I used LR3 before I noticed my abs leaning out overnight but it seemed like a purely cosmetic effect that dissipated as soon as I got off. Any strength gains?

i'm not sure but I suspect people are getting confused with the "receptor grade" & "media grade" terms.

How to know if your IGF-1 Lr3 is real?

Hi boys How to test if our IGF-1 LR3 is true with a blood test? What is it supposed to increase on a blood test, hgh serum or igf-1 level? Which protocol would be ideal!? Example for hgh we do 10ui 3hours before blood. Because when we inject hgh, sérum lvl of hgh show immediately on blood...

thinksteroids.com

 

[samuelclemens95]

i'm not sure but I suspect people are getting confused with the "receptor grade" & "media grade" terms.

How to know if your IGF-1 Lr3 is real?

Hi boys How to test if our IGF-1 LR3 is true with a blood test? What is it supposed to increase on a blood test, hgh serum or igf-1 level? Which protocol would be ideal!? Example for hgh we do 10ui 3hours before blood. Because when we inject hgh, sérum lvl of hgh show immediately on blood...

thinksteroids.com

On paper the only difference should be purity, as you point out. But I am so skeptical of these companies. I think there is at least a better shot of getting something legit if you buy the more expensive one. Receptor grade could be recombinant while media grade could be de novo synthesized. Or it could just be rat insulin.

 

[Daddymcd]

Did you use the receptor grade or media grade? And were the gains permanent? When I used LR3 before I noticed my abs leaning out overnight but it seemed like a purely cosmetic effect that dissipated as soon as I got off. Any strength gains?

Not sure what media grade is, but I bought the most expensive one on there at the time, its the receptor grade.
I maintained size really well and I'm only on 100mg TRT a week.

I think HGH is best for long-term use, but igf-1 blows it out of the water. Ghrp-6 and mk677 also have way better results for a fast bulk. Run all of them with Masteron or winstrol to help with drying out.

 

[samuelclemens95]

Not sure what media grade is, but I bought the most expensive one on there at the time, its the receptor grade.
I maintained size really well and I'm only on 100mg TRT a week.

I think HGH is best for long-term use, but igf-1 blows it out of the water. Ghrp-6 and mk677 also have way better results for a fast bulk. Run all of them with Masteron or winstrol to help with drying out.

thanks for the reply. Did you notice any performance benefits like strength or recovery? Or was it purely cosmetic?

 

[Deadp007]

...I think there is at least a better shot of getting something legit if you buy the more expensive one...

...I bought the most expensive one on there at the time, its the receptor grade...

I don't necessarily believe price is an indicator of quality. But i do understand the delima, sites will often show stellar HPLC testing but what you actually get is something...less.
I think forums like this help to separate the wheat from the chaff.

 

[Daddymcd]

thanks for the reply. Did you notice any performance benefits like strength or recovery? Or was it purely cosmetic?

Oh yeah, idk if I'd recommend that peptide stack to anyone for harm reduction, but I swear nothing compares. Got way bigger than my test/Tren/deca/and oral cycle.
if you decide to run all of them, I'd definitely space the doses at least 6 hours apart, that's just bro science though so you won't overwhelm your body with HGH.

 

[Daddymcd]

I don't necessarily believe price is an indicator of quality. But i do understand the delima, sites will often show stellar HPLC testing but what you actually get is something...less.
I think forums like this help to separate the wheat from the chaff.

Agreed, seemed like the best reviewed and best tested igf-1 I could find at the time though.
I'll probably try out that other peptide site when I run out of semaglitude for the wife... I think it's paradigm peptides or something.

 

[kodine]

^these are the types of posts we need. Nice write up!

@Wunderpus How are you dosing the berberine?

 

[Flex22]

I love reading type-II threads. As intelligent as he is I appreciate the way way he explains it makes it easy to understand. His past and present writings/posts have helped me a lot with both certain anabolic compounds as well as timing and purposes behind gh/igf/slin etc.
My absolute fav combo which im starting again within a week is combing gh and igf-lr3. With my obv current anabolics too. Once my igf lands im gonna do 5iu gh split twice daily and 100-120mcg igf-lr3 postworkout. I do my gh 2.5iu 1.5hr preworkout And again 2.5iu prebed and my 100mcg igf 15min postworkout. The physical changes are so rapid it’s insane.

 

[Type-IIx]

I love reading type-II threads. As intelligent as he is I appreciate the way way he explains it makes it easy to understand. His past and present writings/posts have helped me a lot with both certain anabolic compounds as well as timing and purposes behind gh/igf/slin etc.
My absolute fav combo which im starting again within a week is combing gh and igf-lr3. With my obv current anabolics too. Once my igf lands im gonna do 5iu gh split twice daily and 100-120mcg igf-lr3 postworkout. I do my gh 2.5iu 1.5hr preworkout And again 2.5iu prebed and my 100mcg igf 15min postworkout. The physical changes are so rapid it’s insane.

Thank you for this sentiment bro. I enjoy seeing these sorts of posts, where I'm not even tagged or anything.

 

[willy86]

Because IGF-1 is expensive compared to HGH.
Rare to find, often pharma increlex, a lot of fake.
I am not sure if some UGL offer lyophilised mecasermin, but as far as I know it's not stable and never saw a Jano report of it.

IGF-1 is different from the available cheap versions such as IGF LR3 and DES.
IGF LR3 won't raise your IGF-1 levels but it will make them lower.

And last thing, IGF-1 levels aren't the main benefit of HGH IMO, high IGF-1 levels stimulate lipogenese and make you store fat quicker, most of HGH users love HGH because it can keep you lean.

The 3D visual, good sleep, and all health benefits aren't necessary linked to igf-1 levels but more to HGH serum levels.

Igf-1 is like e2, e2 is results of test conversion, igf-1 is result of hgh conversion, levels are often random, e2 have a lot of benefits but it's not the main reason why we take test, so is igf-1.

Because IGF-1 is expensive compared to HGH.
Rare to find, often pharma increlex, a lot of fake.
I am not sure if some UGL offer lyophilised mecasermin, but as far as I know it's not stable and never saw a Jano report of it.

IGF-1 is different from the available cheap versions such as IGF LR3 and DES.
IGF LR3 won't raise your IGF-1 levels but it will make them lower.

And last thing, IGF-1 levels aren't the main benefit of HGH IMO, high IGF-1 levels stimulate lipogenese and make you store fat quicker, most of HGH users love HGH because it can keep you lean.

The 3D visual, good sleep, and all health benefits aren't necessary linked to igf-1 levels but more to HGH serum levels.

Igf-1 is like e2, e2 is results of test conversion, igf-1 is result of hgh conversion, levels are often random, e2 have a lot of benefits but it's not the main reason why we take test, so is igf-1.

ok, this is very interesting. So how can we find an application for the cheap igf 1 lr3 ?

 

[OnTRT]

Oh yeah, idk if I'd recommend that peptide stack to anyone for harm reduction, but I swear nothing compares. Got way bigger than my test/Tren/deca/and oral cycle.
if you decide to run all of them, I'd definitely space the doses at least 6 hours apart, that's just bro science though so you won't overwhelm your body with HGH.

Sides?