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PanamaVet said:
Thanks, I appreciate your response. We'll give it a try again. She's not taken any for a month now, start back at 5 or go straight to 7.5/10?
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I'd start her on one week of 5mg. Then 7.5 for 4. Keep in mind it takes four weekly doses to reach maximum blood plasma concentration at a given dose. So effects will increase at the same dose from first to fourth dose. Then 10, 12.5 each for 4 weeks. to 15 if she's tolerating it ok and not at goal weight. She can stay at any given dose as long as she wants, 4 is not a limit, Most people find their "maintenance dose" where goal weight has been reached, and no longer experiences appetite suppression, somewhere between 7.5-15.

Finally, UGL tirz is not quite as effective as pharma. It's very likely 20-30 is the actual equivalent to 15mg pharma in efficacy.

Suggest you find a kit with 30mg vials for cost effectiveness.

Finally, make sure you reconstitute in a way that makes each dose .5ml (or more) in volume, not less.
 
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PanamaVet said:
I've gotten several orders from Marcus, all well packaged, and only one delayed shipping issue. My only question is, has anyone else used the tirzepatide with any success? My wife went through 4 vials with little results. Keep in mind, she did not change her eating habits much and did very little exercise to help the process, but still. She only lost a total of 6 pounds from 4 vials.
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Anecdotally I tried one vial of his tirz in the past, 20mg vial, my standard dose that’s been effective with other ugl suppliers was 2.5mg/week with GAs I did the same dosage protocol and it felt less effective. Seemed to wear off almost completely by day 5 and caused a bit more nausea on day 1 and 2, this was consistent for about a month until I switched back to our other supplier and those sides went away within a week.
 
Jeffholio5 said:
Anecdotally I tried one vial of his tirz in the past, 20mg vial, my standard dose that’s been effective with other ugl suppliers was 2.5mg/week with GAs I did the same dosage protocol and it felt less effective. Seemed to wear off almost completely by day 5 and caused a bit more nausea on day 1 and 2, this was consistent for about a month until I switched back to our other supplier and those sides went away within a week.
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Oddly enough, that's the only thing she reported differently, nausea. Never any appetite supression, only nausea.
 
I’ve been using Marcus’s Tirz since July, and it’s been working well. I didn’t follow the usual medical protocols or @Ghoul advice.

I started with 2.5mg for the first four weeks, then went up to 3mg. Now I’m at 4mg a week.

No side effects and no appetite so far - it’s going great.
 
PanamaVet said:
Oddly enough, that's the only thing she reported differently, nausea. Never any appetite supression, only nausea.
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No idea what causes that because other sources we use rarely experience any nausea, GA has a jano test saying it’s legit and dosed correctly. So not sure if it’s an additive or something else causing it to feel different. Id be curious to hear from others that have used it with success and that it feels the same as their other sources.
 
Anat said:
I’ve been using Marcus’s Tirz since July, and it’s been working well. I didn’t follow the usual medical protocols or @Ghoul advice.

I started with 2.5mg for the first four weeks, then went up to 3mg. Now I’m at 4mg a week.

No side effects and no appetite so far - it’s going great.
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LOL, you're following the most important aspect, once a week dosing. That is 90% of what constitutes the "pharma protocol".
 
Ghoul said:
LOL, you're following the most important aspect, once a week dosing. That is 90% of what constitutes the "pharma protocol".
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I read your debates with the guy who injects Tirz every day like testosterone for a steady baseline. I agree that once a week is enough. By the way, thanks for all the helpful info on GLP-1 and the vial adapter spike.
 
Anat said:
I read your debates with the guy who injects Tirz every day like testosterone for a steady baseline. I agree that once a week is enough. By the way, thanks for all the helpful info on GLP-1 and the vial adapter spike.
Click to expand...

The issue about daily dosing concerns taking a "sloppy" copy of a pharma protein drug, which is already much more immunogenic(antibody producing) than the original, and doing the one thing known to worsen that undesired response more than anything else, increasing frequency of exposure.

No, it won't manifest as suddenly feeling ill, or "losing an ass cheek", but much more insidious, slowly manifesting, and potentially very harmful, even lifelong effects.

IMG_9695.webp


 
PanamaVet said:
Started her with the standard 2.5mg/week for a month and then titrated her up to 5mg/week. She has never used any other GLPs.
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Man my wife uses the same drug I recently got it from GA for her only. only 2.5mg a week. 4 weeks passed she lost 11-12 lbs. She is still on 2.5mg because even this dose still kills her daily appetite to eat food. her start weight was 170 now she is 158 ish. first two weeks she didn't even exercise much. Id say fix the diet and make her do more cardio. You gotta be careful not to over eat. It's not like this is dnp you know. wish you guys luck!
 
Ghoul said:
I'd start her on one week of 5mg. Then 7.5 for 4. Keep in mind it takes four weekly doses to reach maximum blood plasma concentration at a given dose. So effects will increase at the same dose from first to fourth dose. Then 10, 12.5 each for 4 weeks. to 15 if she's tolerating it ok and not at goal weight. She can stay at any given dose as long as she wants, 4 is not a limit, Most people find their "maintenance dose" where goal weight has been reached, and no longer experiences appetite suppression, somewhere between 7.5-15.

Finally, UGL tirz is not quite as effective as pharma. It's very likely 20-30 is the actual equivalent to 15mg pharma in efficacy.

Suggest you find a kit with 30mg vials for cost effectiveness.

Finally, make sure you reconstitute in a way that makes each dose .5ml (or more) in volume, not less.
Click to expand...
why .5ml minimum and what happens if it less? would this be true for semiglutide also?
 
Regular Joe said:
why .5ml minimum and what happens if it less? would this be true for semiglutide also?
Click to expand...

It's for two reasons, which apply to all peptide/protein based drugs.

One is pharmacokinetics, the charachteristics of how drug "moves" through your system.

The same dose, injected subq, at a lower volume, raises blood levels at a faster rate than a larger volume.

This rapid increase in blood levels can induce side effects more easily than a gradual rise.

.5ml is what Novo chose for all doses of Tirz, up to 15mg,

For Semaglutide, Eli uses .5ml for all doses up to 1mg. For 1.7 mg and 2.4 mg they use .75ml, to slow the rate it enters the bloodstream.

The second reason is that aggregates, the "clumping" of peptides and other "junk" like fragments, form more quickly the more concentrated the solution. These aggregates waste peptide since they won't work as intended, and are a primary cause of immune reactions, which can induce a long list of undesired effects, from site reactions (swelling, pain, redness), to becoming "immune" to the drug, reducing its effectiveness.
 
Ghoul said:
It's for two reasons, which apply to all peptide/protein based drugs.

One is pharmacokinetics, the charachteristics of how drug "moves" through your system.

The same dose, injected subq, at a lower volume, raises blood levels at a faster rate than a larger volume.

This rapid increase in blood levels can induce side effects more easily than a gradual rise.

.5ml is what Novo chose for all doses of Tirz, up to 15mg,

For Semaglutide, Eli uses .5ml for all doses up to 1mg. For 1.7 mg and 2.4 mg they use .75ml, to slow the rate it enters the bloodstream.

The second reason is that aggregates, the "clumping" of peptides and other "junk" like fragments, form more quickly the more concentrated the solution. These aggregates waste peptide since they won't work as intended, and are a primary cause of immune reactions, which can induce a long list of undesired effects, from site reactions (swelling, pain, redness), to becoming "immune" to the drug, reducing its effectiveness.
Click to expand...
Minor correction: Novo does semaglutide, Eli Lily does tirzepatide. The numbers are correct though for each compound and that's the main thing.
 
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