Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Swolemates365]

So how many mg a week was this?

500mg a week in cruise. Doctor asked for bloods. So wed I only took 125mg and tested following wed.

 

[skubysnacks]

500mg a week in cruise. Doctor asked for bloods. So wed I only took 125mg and tested following wed.

Is that close to where you normally test at for that amount of gear? That seems low to me unless it's normal for you.

 

[Swolemates365]

Is that close to where you normally test at for that amount of gear? That seems low to me unless it's normal for you.

I am for sure not a hyper responsive.. if you look at my thread I had on some purity source gear of test/tren mix. I was taking a but load.

But you also gotta see. I took 1ml 250mg the previous week on Mon then wed. My next shot was a week later missing Mon and only.5ml 125 on that wed and both else till the blood test a week later

 

[skubysnacks]

I am for sure not a hyper responsive.. if you look at my thread I had on some purity source gear of test/tren mix. I was taking a but load.

But you also gotta see. I took 1ml 250mg the previous week on Mon then wed. My next shot was a week later missing Mon and only.5ml 125 on that wed and both else till the blood test a week later

So you pretty much tested where you expected you would?

 

[LuceAniss]

Is that close to where you normally test at for that amount of gear? That seems low to me unless it's normal for you.

It is low. 200mg a week 100/100 puts me at 1330

500mg split 250/250 had me at 2700+

 

[Swolemates365]

It is low. 200mg a week 100/100 puts me at 1330

500mg split 250/250 had me at 2700+

Look at the time between taking that then dropping my dose for blood work. I couldn’t be that high and Dr pull my RX. Plus I’m definitely not a great responder to any meds or alcohol for that matter

 

[skubysnacks]

It is low. 200mg a week 100/100 puts me at 1330

500mg split 250/250 had me at 2700+

Everybody is different. There definitely isn't a one size fits all. I've seen people hit 5000ng/dl or more on 500mg of test e a week.

 

[glpfun]

You ever wonder how many questions could be eliminated from threads if there was some mechanism to keep answers to common questions stickied even in the thread view? We’re in the age of LLMs this should be fairly trivial to implement but I have no clue how extensible the forum software being used is, I suspect it may not be because I see many variations of this type of forum without any novel functionalities tacked on.

Also LLMs expensive to run at scale

 

[bigdaddyandfriends]

First I hope everyone eventually gets their QSC orders. I placed a very large order during their BF sale, got most from USA a few weeks later and then received the rest this past week from China, shipped out 12/31. They couldn't fulfill some of the tabs I ordered (sildenafil and 5-amino-1MQ #100 ea) so gave me a credit for them... which hopefully I will be able to use when they return (being hopeful here).

Second, very interesting discussion on aggregates. As a physician I have not really read much about this until now.

I've been using peptides for years and have frequently mixed various ones together in the same syringe to reduce number of injections, as it is pretty common practice at least in the BB community. These include HCG, GLP1s (sema first, then tirz, now reta), NA Selank Amidate, NA Semax Amidate, bremelanotide, IGF1-LR3, HCG, TB500, BPC157, SS31, MOTS-C, Cu-GHK among others.

I have never noticed any immunogenicity or had any other issues, and peptides always seem to work as intended. That said, the only ones I get a noticeable short term effect from are the IGF1-LR3 (hypoglycemia/fatigue if I don't eat enough) and of course bremelanotide .

There are a few peptides I generally take individually, including GH and GLP1s as they have sometimes become cloudy when mixed with certain others, I attributed this to different pH buffering that may pull something out of solution, but perhaps I was witnessing aggregation? Some mixes do not do this, such as GH & HCG which seem to be fine together, and sometimes I do combine those.

I have never noticed anything related to immunogenicity. Well with the exception of MOTS-C which causes some transient inflammation in nearly everyone, myself included, and I consider it a way to confirm it is real.... I attribute that to it being a mitochondrial peptide that normally is hidden from the immune system, so the body recognizes it as foreign. SS-31 and Humanin/HMG aremitochondrial peptides are also but do not seem to cause any reaction.

I guess I should start injecting everything individually... but I'm 56 and take a lot of shit to keep youthful and vigorous as my wife is 20 years younger. I am thinking aggregation risks likely increase with larger molecules such as GH - if I remember, that is the largest peptide in the body. Very small peptides like BPC probably have minimal risk. Also even injecting everything separate, I suspect some aggregates could theoretically form once they enter the lymphatics/blood... analogous to mixing in the same syringe but with a much higher volume in a slightly alkaline pH ~ 7.4.

I also mix my oils together as most do, common practice and not associated with any issue. I use a mix of anabolics rather than TRT, basically per week 133 test, 120 mast, 67 tren and 13 trestolone all enanthate per week (ZPHC Ultra Mix @ 0.19cc/day) plus another 30mg/day of something else depending on my goals at the time - currently inj YK-11 @ 30mg/day, other times sublingual anavar or IM anadrol pre workout, or my favorite tren A. This keeps my test and estrogen in range with 12.5mg aromasin twice a week, and feel great on it.

 

[gobig2]

I wouldn't be surprised If we get a post from Tracy Sunday night or latest monday a birdie told me

 

[Ghoul]

First I hope everyone eventually gets their QSC orders. I placed a very large order during their BF sale, got most from USA a few weeks later and then received the rest this past week from China, shipped out 12/31. They couldn't fulfill some of the tabs I ordered (sildenafil and 5-amino-1MQ #100 ea) so gave me a credit for them... which hopefully I will be able to use when they return (being hopeful here).

Second, very interesting discussion on aggregates. As a physician I have not really read much about this until now.

I've been using peptides for years and have frequently mixed various ones together in the same syringe to reduce number of injections, as it is pretty common practice at least in the BB community. These include HCG, GLP1s (sema first, then tirz, now reta), NA Selank Amidate, NA Semax Amidate, bremelanotide, IGF1-LR3, HCG, TB500, BPC157, SS31, MOTS-C, Cu-GHK among others.

I have never noticed any immunogenicity or had any other issues, and peptides always seem to work as intended. That said, the only ones I get a noticeable short term effect from are the IGF1-LR3 (hypoglycemia/fatigue if I don't eat enough) and of course bremelanotide .

There are a few peptides I generally take individually, including GH and GLP1s as they have sometimes become cloudy when mixed with certain others, I attributed this to different pH buffering that may pull something out of solution, but perhaps I was witnessing aggregation? Some mixes do not do this, such as GH & HCG which seem to be fine together, and sometimes I do combine those.

I have never noticed anything related to immunogenicity. Well with the exception of MOTS-C which causes some transient inflammation in nearly everyone, myself included, and I consider it a way to confirm it is real.... I attribute that to it being a mitochondrial peptide that normally is hidden from the immune system, so the body recognizes it as foreign. SS-31 and Humanin/HMG aremitochondrial peptides are also but do not seem to cause any reaction.

I guess I should start injecting everything individually... but I'm 56 and take a lot of shit to keep youthful and vigorous as my wife is 20 years younger. I am thinking aggregation risks likely increase with larger molecules such as GH - if I remember, that is the largest peptide in the body. Very small peptides like BPC probably have minimal risk. Also even injecting everything separate, I suspect some aggregates could theoretically form once they enter the lymphatics/blood... analogous to mixing in the same syringe but with a much higher volume in a slightly alkaline pH ~ 7.4.

I also mix my oils together as most do, common practice and not associated with any issue. I use a mix of anabolics rather than TRT, basically per week 133 test, 120 mast, 67 tren and 13 trestolone all enanthate per week (ZPHC Ultra Mix @ 0.19cc/day) plus another 30mg/day of something else depending on my goals at the time - currently inj YK-11 @ 30mg/day, other times sublingual anavar or IM anadrol pre workout, or my favorite tren A. This keeps my test and estrogen in range with 12.5mg aromasin twice a week, and feel great on it.

Just a couple of quick things for you as a medic, and please don't take offense to my use of (New Yorker culture) sarcasm to make a point more concisely, it's intended to communicate more effectively, not to suggest I disrespect the recipient (the contrary tbh, as it takes a few brain cells to interpret).

First, regarding the rather weak standard we have around here regarding harms, essentially "feels" that are disparaged in every other context, and you mentioning you don't "notice immunogenicity".

How long can you drink water from a lead cup before you "notice" anything?

How long can you smoke cigarettes before you "notice" carcinogenic activity?

As far as aggregate size, you're correct, larger aggregates are associated with a stronger immunogenic response. But, more recently, smaller aggregates were discovered to be associated with greater cellular toxicity. This resulted in the FDA lowering the size threshold of aggregates they wanted manufacturers to focus on from above 10um to .10um. Unfortunately .22um filters won't capture the very smallest in that range, but .10um filtration has been shown to, on balance, induce more aggregation than reduce it.

Here's some additional info I posted with an abundance of sarcasm yesterday in response to a perfectly reasonable question, but I'm sure you'll glean more insight from it nonetheless:

Post in thread 'Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!'

Jan 31, 2025

Correct me if I'm wrong, but this is only a significant risk with amyloidogenic peptides? None of which are commonly used here?

That's a keen observation. There are a number of peptide aggregates linked to neurodegeneration (and diseases affecting other organs) and likely many more yet to be discovered.

https://www.sciencedirect.com/science/article/pii/S0962892420301677

While there surely aren't any amyloidegenic peptides in our pure underground Chinese lab produced vials, nor any hiding in the impurities that are entirely uncharacterized except for those closely...

• Ghoul

• 

 

[Swolemates365]

I wouldn't be surprised If we get a post from Tracy Sunday night or latest monday a birdie told me

If they come back. It would be the 10th at earliest.

 

[Maintenance Man]

My last pack landed today with relief. Just a box of peps but glad it made it. Went thru LA customs not being opened. It was mailed out on 1-2 but was tracking the entire time. Just really late updates or a bunch that changed/disappeared who knows.

 

[Garganzola]

i dont even need anything to buy i am more intrigued what happened to tracy

 

[Ghoul]

i dont even need anything to buy i am more intrigued what happened to tracy

Whatever he's doing, I'm sure he's putting his heart into it:

 

[glpfun]

Whatever he's doing, I'm sure he's putting his heart into it:

View attachment 314470

Too much LVH we don’t want this heart

 

[Ghoul]

Too much LVH we don’t want this heart

They'll send you a better heart in your next order.

 

[dasking]

Dec28th my tracking starts, It says it's one state away now. If this is a seizure letter and not my box I'm gonna fuxkin cry lmfao.
(For the LZ tracking there may be hope)

 

[Ghoul]

Dec28th my tracking starts, It says it's one state away now. If this is a seizure letter and not my box I'm gonna fuxkin cry lmfao.
(For the LZ tracking there may be hope)

Seizure letters don't have tracking. Just a fat envelope.

 

[Sicsemptyran]

They'll send you a better heart in your next order.

Is that sterile heart?