Thank you!
Here are my relatively low IGF-1 levels after using about 90iu/day of QSC HGH.
Somatomedin-C (IGF-1) ↑ 977.5 ng/mL 134.0 - 450.0 Serum
Will taking a break help enough if it's this bad, and how long before I can restart with the most effectiveness returned? I'm assuming this can only be figured out after testing.
I've also reduced my frequency, as indicated by the study I sent, before coming off for a little while.
Would you suggest I do RIA for anti-HGH antibody detection? Is ELISA fine? Functional IGF-1 Response Test? Neutralizing Antibody Test? Or is RIA pretty much the only quality go-to?
How long do anti-HGH antibodies persist? I'm assuming my natural production has probably tanked, too.
Would switching brands from QSC temporarily help, or would it have to be a permanent switch? Would it have to be a switch to a pharma brand, or something like SSA would work? Do we know anything about the differences in excipients and aggregation properties between QSC and SSA rHGH?
What about secretagogues for a while?
Do we know anything about the doses taken in this study? Could you please link the study?
Thanks again, Ghoul; so much value each time interacting with you!
As some clowns will tell you, I'm just a guy with google and secretly holding a major investment in filter manufacturers.
I asked ChatGPT (the one in my head) to sum up what it (me) would do if it (me) were in your shoes, and going down the path you've chosen.
Let me add you have an opportunity to also contribute to the community's body of knowledge in a significant way, as there's no "Office of Underground Lab Peptide Safety" pumping out the research a lot of knuckle draggers insist is required to recognize the risk of anything.
They look at pharma clinical trials and say "No immunogenicity problem there, so my UGL peptide is perfectly safe, idiot!"
That's the equivalent of saying Ford demonstrates a new car model can sustain a 40 MPH collision with 0% fatalities, so this $50 Temu GoKart is equally safe.
So in your shoes:
1: Get a baseline GH Antibody Test.
You can't self order it (too little demand), but if you go to a place like UltaLabTests and ask if they can arrange it for you, I think there's a good chance they'll add it to their "menu" of choices, and at a good discount below the standard ~$200.
2. Start filtering, per dose, just before administration. Aggregates take time to develop, the closer to administration the filtering the less time the trash UGL GH formula will have to recreate more aggregates.
This is the equivalent of changing brands. Given you haven't seen response go to zero, I strongly suspect as soon as the immune stimulating factors are reduced, aggregates and impurities. antibodies will drop, and efficacy will increase.
After a 1-3 months check Antibody levels again. If they're lower, you know you're moving in the right direction and should start lowering the dose to compensate for increased efficacy.
It's rare we see such a clear "loss of efficacy" situation, most of the time it's "feels" reports of members claiming bunk gear, that it worked in the past but this batch isn't working, yet tests show the GH is fine.
That's where the common denominator simian mind on Meso loses interest in trying to establish why (despite the fact this happens with pharma, which is why an anti- immunogenicity protocol and GH antibody tests exist). They take a break, or try another brand or switches to pharma, insists the new brand or pharma is the only way to go, never really digging into why HGH that tests good stopped being effective.
Finally, if you take my advice and get a GH antibody test, which I want to emphasize would be groundbreaking in the UGL community, request the lab provide whatever *raw data* is available. I can't find it at the moment, but I've read a report that said an adult GH non responder (in adults with GH deficiency they look at IGF and not growth like children), didn't show a positive result on the GH antibody test, but in the raw data there were antibodies of another type, not normally considered relevant, that were high. Once those were reduced (with a break and switching brands), HGH treatment efficacy was restored for that patient.
*here's the Quest link to the GH Antibody test with the codes you'll need to get someone to order it for you. I believe they're universal.
testdirectory.questdiagnostics.com