How to start HGH for HRT?

[buck]

What are your IGF-1 levels now?
As high HGH/IGF-1 levels are associated with lower life expectancy from many studies Tracking IGF-1 levels seems the way to go as opposed to tracking an arbitrary dosage.

 

[readalot]

I’m almost positive it does but I cannot remember the source on it.

Looking at the PK/PD model it would be hard to rationalize this given the data in Fig. 2

Figure - PMC

Once-daily injectable recombinant human growth hormone (GH) formulations (e.g. Norditropin®; Novo Nordisk A/S) are used to treat GH deficiency in children and adults, with much of the therapeutic effect mediated via the insulin-like growth factor-I ...

pmc.ncbi.nlm.nih.gov

I'll have to look at this more. It's a PK/PD model for GH/IGF-1 vs straight PK model for Test ester. Splitting up the dose for Test ester won't improve mean serum numbers and AUC will stay the same.

Is AUC for IGF-1 changed by GH dosing frequency with same total GH dose per day? Interesting concept but given IGF-1 PD parameters hard to rationalize.

 

[songsofpyramids]

Is AUC for IGF-1 changed by GH dosing frequency with same total GH dose per day?

From what I understand yes. Something to do with multiple gh serum peaks per day as I recall but it’s been a long time since I researched split dosing.

 

[Grey Spartan]

If you shoot the full dose at night, when do you get the blood done to see your igf-1?

I always get my blood work done at 0830 (8am) and I don't eat past 1800 (6pm)

For those that did take it at night, was it subq or IM?

subq

The data:
Natty = 237 @ 47 E2
2.4iu = 230 @ 30 E2
3.6iu = 362 @ 19 E2

 

[Dunkirk]

The data:
Natty = 237 @ 47 E2
2.4iu = 230 @ 30 E2
3.6iu = 362 @ 19 E2

Are you saying HGH lowered your e2? I wasn't aware that was a possibility

 

[MAGA]

This is what 3IU nightly IM of QSC HGH got me:

 

[Tiddiesandnunchucks]

This is what 3IU nightly IM of QSC HGH got me:

View attachment 316733

wait...what???

 

[MAGA]

wait...what???

yea 3IU IM takes me in the upper end of the reference range.

This was me on 5IU IM nightly. It had me almost double the reference range (but gave me some water retention and numbness in my hands), so I backed it off.

Please note units are in nmol/L

 

[Tiddiesandnunchucks]

yea 3IU IM takes me in the upper end of the reference range.

This was me on 5IU IM nightly. It had me almost double the reference range (but gave me some water retention and numbness in my hands), so I backed it off.

Please note units are in nmol/L

View attachment 316740

Thats amazing bro. How does it feel being that high? I'm on the lower end (100ng/ml). Hoping to double it with 1-2iu's per day when I get @Opti package.

 

[readalot]

Please note units are in nmol/L

Thank you sincerely for calling out importance of attaching units to numbers.

 

[Grey Spartan]

Are you saying HGH lowered your e2? I wasn't aware that was a possibility

No

The higher the E2 the greater the IGF-1 from HGH. The key is to find what that number is for you. Example, Dr Todd Lee says he runs his E2 @ 100 for max IGF-1 for his HGH dose.

 

[AlexDavis43]

yea 3IU IM takes me in the upper end of the reference range.

This was me on 5IU IM nightly. It had me almost double the reference range (but gave me some water retention and numbness in my hands), so I backed it off.

Please note units are in nmol/L

View attachment 316740

Thats amazing bro. How does it feel being that high? I'm on the lower end (100ng/ml). Hoping to double it with 1-2iu's per day when I get @Opti package.

On 5 IU/d, 451 ng/dL is a good response.

According to the natty IGF-1 thread, that would typically take 6-7 IU/d.

We're used to seeing IGF-1 expressed as ng/dL.

 

[MAGA]

Thats amazing bro. How does it feel being that high? I'm on the lower end (100ng/ml). Hoping to double it with 1-2iu's per day when I get @Opti package.

I felt like I was always one flex away from having a pump haha. I don't get any lethargy or anything

 

[MAGA]

On 5 IU/d, 451 ng/dL is a good response.

According to the natty IGF-1 thread, that would typically take 6-7 IU/d.

We're used to seeing IGF-1 expressed as ng/dL.

The thing is the QSC kits (according to Jano) are 1-2IU overdosed. So if I was splitting a 10IU vial into 3, I might effectively be getting 3-4IU in reality.

We use nmol/L in Australia

 

[malfeasance]

Folks in the northern hemisphere may be wondering, how does nmol/L translate into ng/mL?

multiply by 7.65

59 x 7.65 = 451

Measuring IGF-1 and IGFBP-3 Profiles in Women Seeking Assisted Reproduction; Relationship to Clinical Parameters (Study 1) - PMC

This study examines the IGF serum profile (IGF-1, IGFBP-3 and the IGF Ratio) from 1633 women who undertook an Assessment Cycle prior to any treatment by assisted reproduction. The idea is to progressively study the IGF profile with a view to ...

pmc.ncbi.nlm.nih.gov