Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!

[bighunanballs]

Is this really correct? If two Different companies measure out at at the same purity and dimer tested via @janoshik and both are showing the HGH to be relatively the same IU wise, how is one giving shit results and the other is like we have struck gold? I just want to know what I'm missing here, not doubting peoples results.

Excipient recipe changes the hgh efficacy. @Ghoul shows evidence there could possibly be coagulation of the peptide chains depending on various factors like excipients, shitty vials, air bubbles, agitation, etc.

 

[Ghoul]

Excipient recipe changes the hgh efficacy. @Ghoul shows evidence there could possibly be coagulation of the peptide chains depending on various factors like excipients, shitty vials, air bubbles, agitation, etc.

Aggregation. at the least, should be completely uncontroversial as a topic. Whatever the starting purity, after reconstitution, any aggregation that takes place means you have less active HGH.

Like you point out, there are many factors that cause it, but I like to focus on one simple factor as an example.

A slight difference in PH can make aggregates form 10x faster. Who puts any effort into managing that with UGL peptides?

 

[Tough54]

Just placed a peptide order through Tansy at SA. Super responsive, fast and professional as always. I’ve been ordering through her for a year now and have had zero issues. Hit her up if you’re looking for a rep

 

[Humpo123]

Hey everyone! I live in NSW, Australia and I have been a long term QSC customer (and loyal supporter - I loved those guys - check out my previous posts). Anyways I just wanted to let everyone know I received touchdown yesterday of a complicated little order. Sigma are legit. Not as cheap as QSC but I would say more professional and a great alternative. Happy juicing everyone!!

PS - I purchased the injectable preworkout “Superhuman Blend” and used it last night. Stunning pump. Not cheap but fucking glorious! The list of ingredients is fkn mental. Will be pairing it tonight with test base - let’s go

How much of the superhuman blend do you use? Been thinking of trying it.

 

[thecmorgan]

A possible error on whose end? Yours or jano's? Or was it the shipping company again?
Was it an error at the other lab that measured 0mg of retatrutide in your vials you were selling to us?
Which one of you is responsible for selling me underdosed semaglutide?
2mg of your competition's semaglutide made me dry-heave every morning like I was in my first trimester. 2mg of your semaglutide makes me want to order takeout. Is that Jano's fault or the shipping company again? Certainly not yours.
You're pretty close to finished around here.
Possible error my fuckin ass.

Was there a test result for ssa that showed 0mg for reta?

 

[Dirthand]

Shipping has been very slow for me this go around compared to what it was last time with these guys.... 15days .... so far...

 

[thecmorgan]

Shipping has been very slow for me this go around compared to what it was last time with these guys.... 15days .... so far...

Peptides only shipment?

 

[Dirthand]

Peptides only shipment?

Doesn't really matter but it's
1 order but 2 shipments.. the peptides havent updated since I got the tracking.. tabs are in the states..

 

[thecmorgan]

Doesn't really matter but it's
1 order but 2 shipments.. the peptides havent updated since I got the tracking.. tabs are in the states..

I was asking because I was told 10 days if I just order peptides. I am going out of town for a couple of weeks and was trying to time the delivery. Thanks for the reply.

 

[Mongo966]

Was there a test result for ssa that showed 0mg for reta?

Maybe <10 pages back you'll find it. It wasn't a jano test so it's not being recognized by the people who sold the product.

 

[bigMoJo]

Another thing : they lie about the solvents they use in their oils. All their oral injectables are made with guaicao while only adrol and sdrol are supposed to have it, according to their pricelists. Had to threw to the bin shitload of winny bottle because of that.

Don't throw away... send to test!

I know... why do it?

It lends credibility to the assertions... and it lends credibility to when we tell those vendors to F off!

 

[Dirthand]

I was asking because I was told 10 days if I just order peptides. I am going out of town for a couple of weeks and was trying to time the delivery. Thanks for the reply.

It's been 12 days for my "just peptides" tracking created.. sorry if I sounded rude...

 

[thecmorgan]

Maybe <10 pages back you'll find it. It wasn't a jano test so it's not being recognized by the people who sold the product.

I looked and all I could find was a test for a different vendor, not ssa.

 

[bigMoJo]

Aggregation. at the least, should be completely uncontroversial as a topic. Whatever the starting purity, after reconstitution, any aggregation that takes place means you have less active HGH.

Like you point out, there are many factors that cause it, but I like to focus on one simple factor as an example.

A slight difference in PH can make aggregates form 10x faster. Who puts any effort into managing that with UGL peptides?

@Ghoul

We're talking about two different stages of the hGH:
1. "Efficacy" as @bighunanballs is referring (Lypholized Stage - powder form);
2. "Aggregation" (Reconstituted Stage - back to liquid).

pH can range just based on the amount of dilutant (Bac Water).

Is their recipe going to have—not only an impact on starting purity—pH levels that affect efficacy/aggregation after reconstituting (even if done appropriately) as well?

Are they using a recipe that is potentially undermining the active ingredient?

 

[Ghoul]

@Ghoul

We're talking about two different stages of the hGH:
1. "Efficacy" as @bighunanballs is referring (Lypholized Stage - powder form);
2. "Aggregation" (Reconstituted Stage - back to liquid).

pH can range just based on the amount of dilutant (Bac Water).

Is their recipe going to have—not only an impact on starting purity—pH levels that affect efficacy/aggregation after reconstituting (even if done appropriately) as well?

Are they using a recipe that is potentially undermining the active ingredient?

Yes aggregate preventing. excipients can diminish starting purity. There's a paper I shared earlier that provided a lot of insight into a pharma company development team going through all sorts of excipients to find the right balance of initial damage and the amount of aggregation that develops later under expected real world conditions for their hgh product.

I'll try to dig that up ( @readalot )

QSC only used mannitol. That could provide deceptively high purity tests versus competitors using other excipients, like PH buffers. which may be much less aggregated after a few days of reconstitution, keeping a higher proportion
of the hgh active.

On the other hand, another paper I can't seem to find, compared numerous pharma hgh formulations and the reported side effects sent to the FDA "post marketing surveillance" system.

They didn't mention this, but I noticed the simplest formations, excipients only for ph control, usually single dose vials intended for immediate use after reconstitution, had the lowest rate of reported side effects,

For instance:

Serostim



vs Norditropin in multi dose pens, with a preservative (histadine) to prevent protein breakdown during lypholizaton, Polyaxmer 188, which protects the hgh from physical damage like shocks that cause aggregation, and phenol, another anti-aggregation excipient, preventing oxidation.

Obviously they chose those ingredients because they decided they were necessary to keep the hgh in good shape during storage and handling, but it certainly costs some amount of purity (that info isn't usually made public, FDA keeps it confidential as a trade secret. It's blacked out in public documents).

It's all these unknowns that makes me think the best practice is to use the smallest dose vials practical, as quickly as possible after reconstitution, thus minimizing the one factor in common to all aggregation development, time.

 

[readalot]

Yes aggregate preventing. excipients can diminish starting purity. There's a paper I shared earlier that provided a lot of insight into a pharma company development team going through all sorts of excipients to find the right balance of initial damage and the amount of aggregation that develops later under expected real world conditions for their hgh product.

I'll try to dig that up ( @readalot )

QSC only used mannitol. That could provide deceptively high purity tests versus competitors using other excipients, like PH buffers. which may be much less aggregated after a few days of reconstitution, keeping a higher proportion
of the hgh active.

On the other hand, another paper I can't seem to find, compared numerous pharma hgh formulations and the reported side effects sent to the FDA "post marketing surveillance" system.

They didn't mention this, but I noticed the simplest formations, excipients only for ph control, usually single dose vials intended for immediate use after reconstitution, had the lowest rate of reported side effects,

For instance:

Serostim

View attachment 317454

vs Norditropin in multi dose pens, with a preservative (histadine) to prevent protein breakdown during lypholizaton, Polyaxmer 188, which protects the hgh from physical damage like shocks that cause aggregation, and phenol, another anti-aggregation excipient, preventing oxidation.

Obviously they chose those ingredients because they decided they were necessary to keep the hgh in good shape during storage and handling, but it certainly costs some amount of purity (that info isn't usually made public, FDA keeps it confidential as a trade secret. It's blacked out in public documents).

It's all these unknowns that makes me think the best practice is to use the smallest dose vials practical, as quickly as possible after reconstitution, thus minimizing the one factor in common to all aggregation development, time.

You are really providing incredible coverage on this topic. Amazing to get this at a forum. For those that want to understand this topic better I'd recommend starting here:

https://www.sciencedirect.com/science/article/abs/pii/S0031686596000490

Reviews both the solid and solution scenarios. From there we could move to more recent papers but the above is a great primer even though it is dated.

More recent review of GH excipients here:

https://thinksteroids.com/community...nt-state-of-generic-gh.134427828/post-3395623

 

[4ster90]

Latest price list

No Oils in the pricelist? Only peptides?

 

[Mongo966]

I looked and all I could find was a test for a different vendor, not ssa.

my bad. It was actually around 16 pages back. Post #4,618
Pictures of the test are included with the message if you want to go back and see it. Remember: nobody knows how to do these tests properly except for Janoshik. So if it’s not a Jano test it’s worthless, ok guys!? lol..

The sigma Audley 10mg white cap retatrutide tested O retatrutide in vial….. Told sales rep Ray this but they just told me to send to Jano.

 

[bigMoJo]

Yes aggregate preventing. excipients can diminish starting purity. There's a paper I shared earlier that provided a lot of insight into a pharma company development team going through all sorts of excipients to find the right balance of initial damage and the amount of aggregation that develops later under expected real world conditions for their hgh product.

I'll try to dig that up ( @readalot )

QSC only used mannitol. That could provide deceptively high purity tests versus competitors using other excipients, like PH buffers. which may be much less aggregated after a few days of reconstitution, keeping a higher proportion
of the hgh active.

On the other hand, another paper I can't seem to find, compared numerous pharma hgh formulations and the reported side effects sent to the FDA "post marketing surveillance" system.

They didn't mention this, but I noticed the simplest formations, excipients only for ph control, usually single dose vials intended for immediate use after reconstitution, had the lowest rate of reported side effects,

For instance:

Serostim

View attachment 317454

vs Norditropin in multi dose pens, with a preservative (histadine) to prevent protein breakdown during lypholizaton, Polyaxmer 188, which protects the hgh from physical damage like shocks that cause aggregation, and phenol, another anti-aggregation excipient, preventing oxidation.

Obviously they chose those ingredients because they decided they were necessary to keep the hgh in good shape during storage and handling, but it certainly costs some amount of purity (that info isn't usually made public, FDA keeps it confidential as a trade secret. It's blacked out in public documents).

It's all these unknowns that makes me think the best practice is to use the smallest dose vials practical, as quickly as possible after reconstitution, thus minimizing the one factor in common to all aggregation development, time.

On it's face, this lends support to why pro bodybuilder's etc. prefer pharma hGH vs UGL... the "recipe" (efficacy) is better.

I think I remember the document you're looking for... I'll try to see if I can dig it up from my records... there are so many from you I've saved.

 

[BamaCrazy]

No Oils in the pricelist? Only peptides?

They stopped selling oils/tabs/raws after CNY.