Nad +

[Photon]

I think the easiest way to see if it is placebo or not is to see how they are (1) reconstituted and (2) how long is it stored for before the vial is finished.

Taken from Wiki
Solutions of NAD+ are colorless and stable for about a week at 4 °C and neutral pH, but decompose rapidly in acidic or alkaline solutions. Upon decomposition, they form products that are enzyme inhibitors.

BAC water is acidic in general. Hospira pH 4.5-7, usually <7.
If you (1) use BAC water or (2) take more than a week to finish a vial, then perhaps the effects you are getting, are simply placebo.

 

[rockyraccoon]

Would it not be more beneficial to do daily pins of glut due to the short half life?

What is the highest concentration you have managed to reconstitute at, for NAD+? Can be hold at at least 400mg/ml? Glut can be done at 700mg/ml, I would think NAD+ is 1/2 that.

1ml BAC water is fine for a 500mg vial.

I think the easiest way to see if it is placebo or not is to see how they are (1) reconstituted and (2) how long is it stored for before the vial is finished.

Taken from Wiki
Solutions of NAD+ are colorless and stable for about a week at 4 °C and neutral pH, but decompose rapidly in acidic or alkaline solutions. Upon decomposition, they form products that are enzyme inhibitors.

BAC water is acidic in general. Hospira pH 4.5-7, usually <7.
If you (1) use BAC water or (2) take more than a week to finish a vial, then perhaps the effects you are getting, are simply placebo.

You see, this is a prime example of analysis paralysis. I finish an entire vial as soon as it's reconstituted. If these noticeable benefits are "placebo" so be it. People who are stuck with this scientific mindset can only accept a world where the only outcomes are in line with their theory/hypothesis or else it's just placebo. Maybe they call it placebo because to self-reflect on what could possibly be their own ignorance would simply be too much for their fragile egos to accept. Not calling you out specifically. These are just my own general ramblings.

 

[rockyraccoon]

But how are you taking it, oral have no uptake and 1g injections is nothing you can do without giving it in a IV for 1-3 hours, otherwise you will be in severe pain

1g IM and no problems, no pain. I'm too dumb to do IV on myself and I certainly don't have 1-3 hours to waste on that shit.

 

[Photon]

1ml BAC water is fine for a 500mg vial.

You see, this is a prime example of analysis paralysis. I finish an entire vial as soon as it's reconstituted. If these noticeable benefits are "placebo" so be it. People who are stuck with this scientific mindset can only accept a world where the only outcomes are in line with their theory/hypothesis or else it's just placebo. Maybe they call it placebo because to self-reflect on what could possibly be their own ignorance would simply be too much for their fragile egos to accept. Not calling you out specifically. These are just my own general ramblings.

I completely agree with you.

I was doing an analysis on whether it was possible to do daily pins with it, with glut mixed in it.

But with how quickly it degrades and those pH requirements, it would be hard to mix anything with it. If you do however pin it immediately, then you don't need to worry about degradation.

 

[rockyraccoon]

I completely agree with you.

I was doing an analysis on whether it was possible to do daily pins with it, with glut mixed in it.

But with how quickly it degrades and those pH requirements, it would be hard to mix anything with it. If you do however pin it immediately, then you don't need to worry about degradation.

It is entirely possible. I mix it with L-Carnitine some days and Glutathione other days. I add some more BAC with those mixes because it can get a little thick otherwise.

Also an interesting read:

Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis - PMC

Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. ...

pmc.ncbi.nlm.nih.gov

 

[GreatOak]

I can't even inject 200mg of NAD without feeling like my lungs are being squeezed in a vice & my breathing becomes very laboured!
Tried titrating up , sq , i.m , etc etc & just don't get on with it. Fucking stuff is awful !
There's a thread on this site somewhere where type IIx says that there is zero bioavailability injecting sq or i.m. Says it's complete snake oil! Take that for what you will!
Stick with glutathione i think!

 

[songsofpyramids]

What I'm gathering is,
Take NAD+ to gain energy, accomplish the exact opposite
Now spiral down the rabbit hole of trying to manage the side effects by adding in other compounds

Using glutathione and nad+ together is used in health and anti aging clinics all over. That’s not using other compounds to fix sides, rather its a fairly popular anti inflammatory and anti aging protocol. Using TMG with both drugs is required because they tap your methyl donors hard. Adding supplemental NAC on top, which I run all the time anyway, increases rate of glutathione synthesis and recycling, and rate of redox.

It’s interesting stuff, and it definitely has physical impact, but these protocols are fairly new and lacking robust science as well as expensive and requires research to do it safe.

 

[songsofpyramids]

There's a thread on this site somewhere where type IIx says that there is zero bioavailability injecting sq or i.m. Says it's complete snake oil! Take that for what you will!
Stick with glutathione i think!

I think the science is not zero bioavailability but very poor bioavailability outside of IV. I definitely notice it, and it impacts my sleep if I take it too late. I do think glutathione is the superior drug in area though. I much prefer it.

 

[Mariafitness]

1g IM and no problems, no pain. I'm too dumb to do IV on myself and I certainly don't have 1-3 hours to waste on that shit.

I can't even inject 200mg of NAD without feeling like my lungs are being squeezed in a vice & my breathing becomes very laboured!
Tried titrating up , sq , i.m , etc etc & just don't get on with it. Fucking stuff is awful !
There's a thread on this site somewhere where type IIx says that there is zero bioavailability injecting sq or i.m. Says it's complete snake oil! Take that for what you will!
Stick with glutathione i think!

This shouldent be possible. 1g im straight away would make you sezure. wich vendor do you use? i wonder if its niacinamide riboside in the vials instead of nad+

Fun to see you had great results. i looked like 10 years younger after a infusion two days in a row. it was insaine to see, like black magic. just not possible to continue with so long infusions over and over

 

[songsofpyramids]

it was insaine to see, like black magic. just not possible to continue with so long infusions over and over

IV Nad+ and IV Glutathione with lactic ringers really is fucking awesome. Did both after having covid and it raised me from the dead. I should just find somewhere to get the ringers and have my nurse friends plug me in.

 

[rockyraccoon]

This shouldent be possible. 1g im straight away would make you sezure. wich vendor do you use? i wonder if its niacinamide riboside in the vials instead of nad+

Fun to see you had great results. i looked like 10 years younger after a infusion two days in a row. it was insaine to see, like black magic. just not possible to continue with so long infusions over and over

lol it's very much possible. NAD+ from SSA. Check the lab reports...

 

[Mariafitness]

lol it's very much possible. NAD+ from SSA. Check the lab reports...

hmm.. whats intresting is that SSAs nad+ is bufferd. i dont think just buffer the nad+ could remove all the sides, as IV clinics must have tried that

 

[Mrhairyman]

It seems like everyone's protocol is different, is NAD+ dose depended upon each individual ?

What is a good starting point for Nad+ and Glutathione , looking to gain energy and congestive benefits

 

[Demondosage]

After reading this thread and all the replies I think I’d have to save my money. This nad+ sounds a bit too experimental phase for me to bother with using, thanks for sharing all of your experiences with it as I’ve been hearing more and more abt this lately

 

[Middus]

I had this issue as well and if its not from lack of methylation it can be due to tanking blood sugar. if its a oral nad booster i need carbs with it

I suspect this might be the issue for me

 

[Middus]

After reading this thread and all the replies I think I’d have to save my money. This nad+ sounds a bit too experimental phase for me to bother with using, thanks for sharing all of your experiences with it as I’ve been hearing more and more abt this lately

LoL Nad is cheap as hell

 

[amazonas]

I've been on NAD+ for a while now, tried twice a week, three times a week and recently ED dosing. The problem is i get lethargic as fuck 1 hour post injection, i start yawning and just feel tired. It's counterproductive when it's supposed to give you a boost in energy... and be good before working out.

Has anyone else experienced this?

Tried dosages ranging from 50mg - 200mg

 

[Nidus]

I've been on NAD+ for a while now, tried twice a week, three times a week and recently ED dosing. The problem is i get lethargic as fuck 1 hour post injection, i start yawning and just feel tired. It's counterproductive when it's supposed to give you a boost in energy... and be good before working out.

Has anyone else experienced this?

Tried dosages ranging from 50mg - 200mg

NAD+ can cause vasodilation which usually drops the BP significantly, in my own experience it remains really low for an hour or so

 

[CharlesV]

bumping an old ass thread to see if we have any more anecdotal evidence about NAD. wanting to add some more compounds to the mix, but there really seems to be mixed first hand reports about its effectiveness. lots of good info about what it is supposed to do, but folks in meso don’t seem to be on board with it.

 

[CharlesV]

fuck it. i had a reship due to me and piggybacked some NAD 1000mg. i’ll report back in a couple of weeks.