BigTomJ
Member
nobody mentioned DHT derivatives smooth brain.
k bye!
MESO-Rx
Anabolic Steroids
Finally Legitimate DHT Enanthate w COA?
- Thread starter littlebicepsbigdick
- Start date
Just take test and aromatase inhibitors if necessary, obviously the test is going to go into your “downregulated” 5ar and then create dht.
29trt
Member
So you are saying that ballerinas that lack dht from poor conversion of test will benefit from exogenous DHT? JK
i guess people reading this thread were hoping for a more universal improvement and hence the responses you got...
But if your 5AR is converting test ok than on 2g of test you will have plenty of DHT to blow through ballerinas like there's no tomorrow....
godsgifttoearth
Member
if you have an impairment of tissue specific 5ar, taking DHT doesn't help anymore than just taking a shit load of any other androgen. the tissue specific 5ar amplification in places like the brain and spine, keeping that specific amplified signalling concentrated in that tissue is what is doing the DHT specific thing. serum/systemic DHT is just another androgen floating around that gets taken down by 3αHSD pretty quickly when issued systemically.
littlebicepsbigdick
New Member
Brother. Please provide receipts. No "other androgen" is involved in the bio-synthesis of 5AR except Testosterone and DHT. That alone nullifies your statement.
Exogenous Testosterone + Finasteride = heavily suppressed 5AR synthesis.
Exogenous DHT + Finasteride = Upregulated and restored 5AR synthesis in the presence of 5ARi.
Please stop spreading misinformation for the sake of your ego. The world is headed to a scary place, everyone is a biologist these days smh. This is the reason I said if you're not interested just keep it pushing. So many brains here, yet collectively the level of intelligence doesn't break the speed limit... Sigh... It's all just so...
I'm done replying to these goofy posts. You're all right. I have no clue what I'm talking about. You win I lose. Lol.
Abstract
Full Study
I have better things to be doing then giving out free education to guys who have it all figured out smh lol
Why are you so butthurt
BigTomJ
Member
Lol, he really just posted a 34 year old study he couldn't properly interpret as a source for his hair brained bafoonery
“by which formation of trace amounts of dihydrotestosterone induces 5 alpha-reductase, thereby increasing dihydrotestosterone synthesis and triggering a positive developmental cascade.”
So this should even work if you had downregulated 5ar expression, as long as you aren’t using finasteride.
No exogenous DHT required.
TheScholarOfBrew
Banned
That's extremely interesting after I made post talking about creating proviron E or Cyp..... And its also interesting they have reviews starting this month as of may 17....If you're one of those anti DHT ballerinas just check out now, no one cares, go back to the hair loss thread bbbyyyeee (wave)
So long story short it looks like there is finally a legit Source for DHT Enanthate available with a Certificate of Analysis from an American based lab called BioRegen.
A bunch of the BowTie guys on X and BlackCoffeeMD put up a $1600 bounty claiming DHTE doesn't exist and if it did to send it to BioRegen for analysis as the were claiming @janoshik said he didn't even have the ability to do NMR on it. Don't know if that's true.
Here is the link. Do your own Due Diligence and purchase at your own risk. If you want 5% off your order use Code: Sobe5
I tried to get a larger discount code by telling them Meso has huge pull in the community but as they're the only supplier right now (that has proof of product, seemingly) they hold all the leverage...
What does everyone (who is not a ballerina) think?
DHT Enanthate – 100mg/mL – 5AR Society
Spec Sheet Concentration 100 mg/mL Volume 10 mL Carrier USP-grade MCT oil Appearance Clear to very light yellow Verification 1. LC-MS COA 2. ¹H-NMR spectrum matched to DHT-Enanthate Manufacture Aseptic filtered (0.22 µm PTFE) Intended use Research / analytical reference only – not...5arsociety.com
That cost is insane.
Whats the dosage for this?
littlebicepsbigdick
New Member
The point is that DHT is incalculably more potent at inducing 5AR upregulation than testosterone, with or without the use of 5ARi through independently mediated mechanisms. Yes using HDACi and running high test can and has made some progress but if ppl want to speed the process up that's where the use of DHT comes in.
It's wild to me how many people are so butthurt about people understanding biology more than them. Boldly making claims about X,Y and Z and thinking they're smart enough to tell others what is useful and what is useless. There is a difference in approaching a subject with honest curiosity vs making outright ignorant / false claims and proudly thinking you know it as a fact. You don't see how dumb you actually look lol.
Glad to see little Timmy is still adding so much value to this thread using facts and evidence lol. If a 34 year old study is useless, than at your age you may as well jump off a cliff, I'm sure society would mourn the loss of your outstanding contributions lmaooo
As for why I come across as butt hurt just call me a eugenicist. Everyone has a mental list of groups of ppl who they would prefer didn't exist, and if the choice had to be made everyone has their preferences. For most ppl that's usually categorized by Race. For me it's intelligence. Get it?
littlebicepsbigdick
New Member
To be honest some ppl are trying low doses 50-70mg a week, others are allegedly cranking up to 400mg a week with blood working showing Free DHT 8x the ref range talking about their experience. If you go look at 5AR Society on X they are posting and retweeting ppl who have used their stuff. Allegedly. The main convo around DHTE is on there. Like always be skeptical about claims without evidence, but I mean until more ppl try it out (which apparently some ppl on here are totally against because they barely passed grade 10 biology) we won't get a real verdict on it. But so far it sounds like its giving the hyper-androgenized outcomes people are looking for.
TheScholarOfBrew
Banned
Cost too high atm. But im certain they made a certain amount with the dht base and attached the ester with a small batch. Probably had a lab help. Guess they testing the waters to see if it sells.
BigTomJ
Member
More yapping from the weak minded little boy who can't tolerate critism.
If you just wanted an echo chamber for you to larp as an intellectual you should have stayed on X.
You talk like a child who watched a few YouTube videos and made a couple chat gpt queries.
In this entire thread you have not once addressed any criticism but instead deflected with ad hominem and strawmen arguments.
The irony of arguing in such a fashion while parading as some intellectual paragon is absolutely comical.
As far as I've seen, you haven't even articulated what benefit you are expecting to get from exogenous DHT.
If you just wanted an echo chamber for you to larp as an intellectual you should have stayed on X.
You talk like a child who watched a few YouTube videos and made a couple chat gpt queries.
In this entire thread you have not once addressed any criticism but instead deflected with ad hominem and strawmen arguments.
The irony of arguing in such a fashion while parading as some intellectual paragon is absolutely comical.
As far as I've seen, you haven't even articulated what benefit you are expecting to get from exogenous DHT.
TheScholarOfBrew
Banned
I will buy a vial just for lulz. Im curious i also have no hairloss despite test. tren mast and anything else even at age 29. So either this stuff will kill my hair or make me more androgenic lol
Ghoul
Member
Why don't you consult ChatGPT to come up with your own unique insults, or invest some time working on leveling up from a falling inner city elementary school level writing ability?
explodingHeart
Member
i've been on duta for almost 13 years. Blasted test plenty of times yet have more hair than what I started with thanks to duta + oral minox.
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littlebicepsbigdick
New Member
Yeah you're definitely retarded, we just spent the last 5 posts discussing what to expect from exogenous DHT (hyper accelerated 5AR upregulation). Literally fkkn L.O.L How many times did you get dropped on your head as a baby lmaooo
Talking about ad hominem, how about you first address how I misunderstood the study I posted. Remember that claim Tiny Tim? I'm expecting crickets...
I've clearly stated one (there are many) objective of using exogenous DHT (which your first post on this thread said was a waste of time, because you are an objectively dumb human). I can post a plethora of literature like the study I posted above (which you claimed I couldn't interpret without countering any claim I made) as to how low DHT levels are associated with negative outcomes in every single disease of neurological degeneration and cellular oxidation (Alzheimer's, ALS, Amyloid Plaque Oxidation and Cholesterol Oxidation) but I'm not going to because I don't care to help you learn. I'm probably reading the studies wrong according to you anyway lmao. And like you said, hopefully I get a huge discount because it's a huge waste of time and money lol.
You showed up. Stated that exogenous DHT is factually a waste. Which means that you know that to be the ultimate truth. At that point you pronounced your ignorance. Since then you have not posted a single reason as to why it's a waste (aside from your bold unscientific claim) for me to counter. Yet youre putting the burden of proof on me? You didn't ask me what DHTE is good for. You stated it was a waste. End of.
The other guy tried to claim that all androgens are involved in the bio synthesis of 5AR, then when he was corrected, he tried to claim that T without Fin is enough, and since then he hasn't replied because I addressed everything he thought he was saying in his two posts.
So please, go ahead say something retarded (shouldn't be hard for you) so I can dismantle and embarrass you. Go on, don't be shy lol. You wanna get into the science let's go Tiny T, pick which way you want to get embarrassed.
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29trt
Member
Considering this is not my first language I think I am doing ok....
I'm not in the camp that does not recognize that your answers are helpful,just sometimes you say dumb shit , hey we all do... This time I was the one to spot it...
BigTomJ
Member
Self proclaimed "bio hacker" with an ego the size of texas. Never gets old.
The study you cited, is dated, and is using the ever popular rodent prostate model. Which we know doesn't correlate to humans well if at all. My statement that you couldn't interpret it was based in that fact, not ad hominem.
you never states specifically what you're trying to to achieve.
Do you have low serum DHT levels?
Have you gone through chemo?
Are you a diabetic?
What makes you think that you have a downregulated 5ar?
And in addition, what makes you think exogenous testosterone still doesn't supply enough DHT even with 5ar downregulation?
What is the practical application of what you are trying to promote?
Even esterized with enanthate, DHT is eliminated so quickly in vivo as soon as esterase clears the enanthate that DHT molecule is only lasting 15-30m.
Having the ester attached also probably won't prevent normal elimination through 3a/3b-hsd, meaning most of that active DHT is going to be eliminated before esterase has an opportunity to cleave the enanthate and allow the DHT to freely circulate.
What you're discussing has essentially zero ecidenciary or clinical backing, you cannot make any actual claims on the benefits or efficacy of the therapy you're describing.
You have a hypothesis that you apparently are planning a n=1 experiment to explore.
So I ask again, because you still haven't answered:
Why do you think exogenous DHT injections will be beneficial to you, and others?
What specific benefits are you hoping for?
How do you plan on testing your hypothesis?
Sincerely,
A ballerina
littlebicepsbigdick
New Member
My personal biological stasis has nothing to do with the issues you're experiencing here and is no one's business but mine. There are ppl here who are interested in DHTE, a verified source became available so I let them know. It doesn't matter what my personal goals are. Goals will differ for everyone who wants to use the drug. That's their business not yours, not mine.
DHTE works like every other esterified steroid. The whole point is to inject in to a depot that slow releases as the esterases de-esterify the DHT so it can go and bind to the AR. It's just like DHT no ester but with a higher bioavailability through injection with a steady stream of DHT being released and hitting the androgen receptor.
3aHSD can NOT bind to and reduce DHTE before it is cleaved off from the enanthate ester at the 17β-hydroxyl group, that is where 3aHSD binds to the DHT. 3bHSD has nothing to do with this process at all, so I don't know why you even mentioned it but ok.
So yes, while it will only be active for 30 minutes or so, the whole point is to have a steady supply of DHT being released from the depot into the blood stream. The other options are slamming a highly bio unavailable oral suspension or slapping on cream multiple times a day.
I already told you the benefit I am looking for in my last post and 5 posts before that. You claim that the study is of no validity due to an erroneous claim about the model not being biologically compatible to humans without citing any evidence to support your claim. Ps that's because it's not true.
How will I be measuring my results is again my business (Novogene). Like I said; I came here to let ppl who are looking for DHTE know there is now a verified source available. I told anyone who has a different world view to keep it pushing. This argument is as retarded as Keto vs Carb. Just pick what you want and fuck off lmao. The fact you keep posting on MY THREAD says everything that needs to be said lol.
You also said "And in addition, what makes you think exogenous testosterone still doesn't supply enough DHT even with 5ar downregulation?"
Man this is worse than slitting my wrists. When did I say exogenous T doesn't supply enough DHT. It supply's DHT, and depending on your 5AR activity it supplies varying amounts. If you want to upregulate the amount of 5AR activity then you're free to fucking do so via exogenous DHT.
How TF is no one seeing how exhausting and repetitive this Tin Can is... he is either purposely being obtuse to drag this on because he has no vagina to swim in, or he is genuinely mentally handicapped in which case fckk my life for engaging with this.
I'm no longer responding to you. Just figure it out bud.
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